Search results for "GRP"
showing 10 items of 32 documents
IMPLEMENTAZIONE DI TECNICHE NDT DI TERMOGRAFIA AD INFRAROSSI SU PANNELLI IN COMPOSITO GRP PER APPLICAZIONI NAUTICHE
2010
Il presente lavoro descrive l’implementazione di due tecniche di termografia attiva ad infrarossi per il controllo non distruttivo (IRNDT) di delaminazioni sub-superficiali su pannelli in composito (GRP) di grosso spessore, tipicamente impiegati per uso navale. Si è in particolare fatto uso di attrezzature a basso costo consistenti in comuni lampade alogene a bassa potenza come sorgenti di calore esterne, ed una termocamera ad infrarossi a singolo sensore a bassa risoluzione termica e basso frame rate. Le due tecniche implementate sono la Pulsed Thermography (PT) ed una nuova variante di Lock-In Thermography denominata Pulse-Modulated Lock-In Thermography (PMLT), basata sull’analisi in freq…
IMPLEMENTAZIONE DI TECNICHE DI TERMOGRAFIA ATTIVA IRNDT SU COMPOSITI GRP MEDIANTE LA DEPOSIZIONE DI IMPULSI TERMICI DI LUNGA DURATA
2011
Nel presente lavoro viene analizzata l’implementazione di tecniche attive di termografia ad infrarossi per analisi NDT su pannelli in composito. In particolare si propone l’uso di lampade alogene come sorgente di calore esterna, le quali richiedono tempi di accensione dell’ordine di diversi secondi al fine di depositare efficaci quantità di calore. Si discutono quindi le problematiche connesse all’implementazione di tecniche di Transient Thermography e di Lock-In Thermography in presenza di tempi lunghi di deposizione di calore. Viene implementata una tecnica di modulazione della deposizione di calore mediante treni di onde quadre di lunga durata (PMLT - Pulse Modulated Lock-In Thermography…
Susceptibility variants for obesity and type 2 diabetes mellitus in the population of Latvia
2014
Darbs ietver pētījumus par riska gēnu lokusos esošo biežo variantu saistību ar 2.tipa cukura diabētu (T2D) un aptaukošanos Latvijas populācijā. Pētījumu parādīja, ka potenciāli funkcionāls variants AGRP asociējas ar paaugstinātu ĶMI. Savukārt, adiponektīna gēna rajonā esošie varianti nav uzskatāmi par būtiskiem aptaukošanās un T2D riska faktoriem mūsu populācijā, bet iespējams ir iesaistīti kardiovaskulāro saslimšanu patoģenēzē. Varianti TCF7L2 ir nozīmīgi T2D riska faktori pacientiem ar normālu ķermeņa svaru. Iegūtie dati papildina informāciju par FTO un TMEM18 rajonos esošo adipozitātes riska variantu saistību ar T2D neatkarīgi no to ietekmes uz izmaiņām ĶMI. Varianti FTO ceturtajā intron…
Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
2016
Background & Aims: A novel family of proton-sensing G-proteinâcoupled receptors, including ovarian cancer G-proteinâcoupled receptor 1 (OGR1) (GPR68) has been identified to play a role in pH homeostasis. Hypoxia is known to change tissue pH as a result of anaerobic glucose metabolism through the stabilization of hypoxia-inducible factor-1α. We investigated how hypoxia regulates the expression of OGR1 in the intestinal mucosa and associated cells. Methods: OGR1 expression in murine tumors, human colonic tissue, and myeloid cells was determined by quantitative reverse-transcription polymerase chain reaction. The influence of hypoxia on OGR1 expression was studied in monocytes/macrophages and…
Les médiévistes et le don. Avant et après la théorie maussienne
2008
The medievalists, as well the anthropologists and the sociologists, have forgotten that « gift-counter-gift » or « gift-exchange » (Gegengabe, Widergabe, Gebentausch), concepts used by Marcel Mauss in his classical « Essai sur le don », have been forged at the nineteenth century by the historians of the medieval german law and language (Jacob Grimm, Karl von Amira, Richard M. Meyer...), in a context of criticism against the capitalism. Thus, the concepts historicity seems essential to a reasoned use of theory in social sciences.
Grp78 overexpression triggers pink1-ip3 r-mediated neuroprotective mitophagy
2021
An experimental model of spinal root avulsion (RA) is useful to study causal molecular programs that drive retrograde neurodegeneration after neuron-target disconnection. This neurode-generative process shares common characteristics with neuronal disease-related processes such as the presence of endoplasmic reticulum (ER) stress and autophagy flux blockage. We previously found that the overexpression of GRP78 promoted motoneuronal neuroprotection after RA. After that, we aimed to unravel the underlying mechanism by carrying out a comparative unbiased proteomic analysis and pharmacological and genetic interventions. Unexpectedly, mitochondrial factors turned out to be most altered when GRP78…
Erenumab and Possible CGRP Effect on Chronotype in Chronic Migraine: A Real-Life Study of 12 Months Treatment
2023
The introduction of monoclonal antibodies (mAbs) directed against the calcitonin gene-related peptide (CGRP), or its receptor (CGRPr), revolutionized migraine management due to their high efficacy and few side effects. Data suggest that the CGRP may even be implicated in circadian rhythm, but studies about the effect of anti-CGRP treatments on sleep are still lacking. The aim of the present study was to assess the effect of erenumab (70 and 140 mg per month), a human mAb directed against CGRPr, on chronotype in chronic migraineurs; secondly, we assessed its efficacy, safety, and the effects on anxiety and depression. Sleep was evaluated using self-administrable questionnaires investigating …
Application d’un modèle conceptuel à l’analyse de la dynamique hydrométéorologique des crues dans un bassin-versant en milieu tropical humide : cas d…
2015
7 pages; International audience; Application of a conceptual model to analysis of dynamic hydrometeorological flood in a pool - side in tropicalmoist environment : the case of Mono river. The objective of this study is to analyze the dynamics of the basinhydrometeorological and distribution of incoming flood dam Nangbéto to assess the risk of flooding in the lower valley of theriver. The data used are: daily flows of Mono (m3.s-1) and Nangbéto Athiémé, evapotranspiration (mm / day, calculatedaccording to the method Oudin et al., 2005) and the average precipitation over the basin (mm / day) covering the period1988- 2010. The method of spatial interpolation of rainfall tested is that of ordin…
Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase
2009
The complex regional pain syndrome (CRPS) is characterized by enhanced neurogenic inflammation, mediated by neuropeptides. Neutral endopeptidase (NEP) is a key enzyme in neuropeptide catabolism. We used NEP knock out (ko) mice to investigate whether NEP deficiency leads to increased pain behavior and signs of neurogenic inflammation after soft tissue trauma with and without nerve injury. After chronic constriction injury (CCI) of the right sciatic nerve, NEP ko mice were more sensitive to heat, to mechanical stimuli, and to cold than wild type mice. Tissue injury without nerve injury produced no differences between genotypes. After CCI, NEP ko mice showed increased hind paw edema but lower …
Migraine and cluster headache – the common link
2018
Abstract Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability…