Search results for "GUI"

Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites

2022

AbstractAmyloid protein aggregates are not only associated with neurodegenerative diseases and may also occur as unwanted by-products in protein-based therapeutics. Surfactants are often employed to stabilize protein formulations and reduce the risk of aggregation. However, surfactants alter protein-protein interactions and may thus modulate the physicochemical characteristics of any aggregates formed. Human insulin aggregation was induced at low pH in the presence of varying concentrations of the surfactant polysorbate 80. Various spectroscopic and imaging methods were used to study the aggregation kinetics, as well as structure and morphology of the formed aggregates. Molecular dynamics s…

Appearance as the Arrival of the Future

2017

AMBIGUITIES of language often indicate a problematic subject matter. That is the case with the word "appear" (erscheinen). When I say that an acquaintance (or someone with whom I was previously unacquainted) "appeared" to me, in order to speak with me, the meaning is: he came to me, he showed up in my habitat, perhaps at my home. He did not only seem (scheinen) to be there; he really was there. When something appears to us, it does not only seem to be with us, it actually is present. Appearance and existence are here very closely connected. But on the other hand, my acquaintance still exists even when he does not appear to me. Whether that would still be true if he appeared nowhere whether …

PHARMACOLOGICAL MANAGEMENT OF THE POLYTRAUMA PATIENT. ON ANALGESIC THERAPY GUIDELINES

2022

In consideration of the constant, if not increasing number of polytrauma patients arriving in emergency rooms, the pharmacological treatment of pain is a topic that is always under observation and innovation. Even more important is the global management of pain in the polytrauma patient, i.e. its treatment in the phases even after hospitalisation. The existence of pharmacotherapeutic protocols is today an aid for the physician in order to act in the most appropriate way in the shortest possible time. This brief commentary is intended to be a practical guide to the analgesic treatment of the polytrauma patient, in the light of the most recent scientific evidence.

Sympathetic blocks for visceral cancer pain management: A systematic review and EAPC recommendations.

2015

The neurolytic blocks of sympathetic pathways, including celiac plexus block (CPB) and superior hypogastric plexus block (SHPB) , have been used for years. The aim of this review was to assess the evidence to support the performance of sympathetic blocks in cancer patients with abdominal visceral pain. Only comparison studies were included. All data from the eligible trials were analyzed using the GRADE system. Twenty-seven controlled studies were considered. CPB, regardless of the technique used, improved analgesia and/or decrease opioid consumption, and decreased opioid-induced adverse effects in comparison with a conventional analgesic treatment. In one study patients treated with superi…

Colloquialità e dialetto nella Palermo d'oggi

2015

L'incesto della parola. Lingua e scrittura in Silvana Grasso

2009

Marina Castiglione in questo saggio – il primo interamente dedicato a Silvana Grasso, importante voce della letteratura contemporanea – mette in luce come i romanzi dell’autrice siciliana si presentino mutuamente intellegibili alla luce di un materiale linguistico e stilistico (oltre che tematico) che rimbalza dall’uno all’altro anche a notevoli distanze temporali. L’esposizione consente di far emergere, ai diversi livelli della scrittura, costanti, modifiche e variabili che danno all’intero corpus unitarietà nelle intenzioni e una assoluta inscindibilità tra lingua e fabula. Lingua e identità sono, infatti, una bussola certa nell’orizzonte frastagliato delle realtà rappresentate. Il ricors…

Terapia medica del sanguinamento uterino anomalo.

2003

The popularization of plate tectonics: presenting the concepts of dynamics and time

1996

There have been many attempts to describe and represent the theory of plate tectonics to laypeople. In the context of a study conducted at the request of a museum, we have tried to determine how the concepts of both geological time and the movements of the plates have been reformulated. After having systematically studied in detail publications aimed at more or less educated readers, we have selected a corpus of twelve articles from nine different magazines or journals. Among the different means of expression used by the popularizers, rhetorical figures constitute a significant resource. Procedures based on analogy (metaphor, comparison, analogical reasoning) were brought together in a sing…

Application of analogy in the teaching of french in China

2014

The analogy refers to a non-coincidental similarity between two things or two ideas of different nature. It is a cognitive process whereby information attached to a specific element is transferred to another specific element, and plays an important role in the process of memorization, communication and problem solving. It is used as a method in many disciplines, it also has its own definition in different areas. In linguistic research, the analogy is also a very interesting topic. According to our research, we find that the analogy has an important influence on the creation and the evolution of a language, when we learn a language, the correct analogy also plays a positive role, it is possi…

La Grammaire de Condillac face au paradoxe de l'origine naturelle du langage

2012

The recent discovery of mirror neurons has rivived the gestural-imitative theory of the origin of language advocated by Condillac in the XVIIIth century. Condillac develops this theory in two stages: in the Essai (1746) he proposes a gestural theory based on the arbitrariness of the sign, while in the Grammaire (1775) he refuses arbitrariness and accepts the theory of analogy and natural imitation proposed by Charles de Brosses (1765). This choice depends on the fact that in Rousseau (1755) and Beauzee (1765) arbitrariness, as a "paradox of the original contract", now plays the role of key argument in favor of the divine origin of language. So, the theory of analogy and natural imitation is…