Search results for "GV"

Differential effects of calcium channel antagonists (omega-conotoxin GVIA, nifedipine, verapamil) on the electrically-evoked release of [3H]acetylcho…

1990

Electrically-evoked release of [3H]acetylcholine from autonomic neurons (myenteric plexus), motoneurons (phrenic nerve) and the central nervous system (neocortex) was investigated in the presence and absence of the calcium channel antagonists omega-conotoxin GVIA, nifedipine and verapamil, whereby the same species (rat) was used in all experiments. Release of [3H]acetylcholine was measured after incubation of the tissue with [3H]choline. omega-Conotoxin GVIA markedly reduced (70%) the evoked release of [3H]acetylcholine from the myenteric plexus of the small intestine (IC50: 0.7 nmol/l) with a similar potency at 3 and 10 Hz stimulation. An increase in the extracellular calcium concentration…

Inhibition of mechanical activity by neurotensin in rat proximal colon: involvement of nitric oxide.

1997

The aim of the present study was to define the nature of inhibitory action of neurotensin in rat proximal colon. Mechanical activity was detected as changes of intraluminal pressure. Neurotensin (10(-10) to 10(-7) M), in the presence of atropine (10(-6) M), guanethidine (10(-6) M), and nifedipine (10(-8) M), induced a tetrodotoxin-insensitive inhibitory effect characterized by the complete disappearance of the spontaneous phasic contractions. The inhibitory effect of neurotensin (10(-7) M) was abolished by scorpion venom (Leiurus quinquestriatus hebraeus) (10(-6) g/ml) or high K+ (40 mM KCl), whereas it persisted in the presence of omega-conotoxin GVIA, (10(-7) M). N omega-nitro-L-arginine…

Cardiorespiratory fitness measured with cardiopulmonary exercise testing and mortality in patients with cardiovascular disease: A systematic review a…

2021

Highlights • High cardiorespiratory fitness (CRF) in patients with cardiovascular disease (CVD) is associated with 58% lower all-cause mortality risk and 73% lower cardiovascular mortality risk compared to unfit counterparts. • Each 1 metabolic equivalent (1-MET) increase in CRF is associated with a 19% lower CVD mortality risk among patients with CVD. • Coronary artery disease patients with high CRF have a 68% lower all-cause mortality risk than their unfit counterparts. • Each 1-MET increase in CRF is associated with a 17% lower all-cause mortality risk among patients with coronary artery disease. • No significant associations were found between increments of 1-MET and lower mortality ris…

Janus kinase (JAK) 2 V617F mutation as the cause of primary thrombocythemia in acromegaly with severe visceromegaly and divergence between growth hor…

2012

OBJECTIVE: An increased prevalence of hematological abnormalities is reported in acromegaly, but to date no reports about the presence of the Janus Kinase (JAK) 2 mutation in acromegalic patients have been described. DESIGN: We report the complex clinical presentation of the unique case, never described, of acromegaly due to GH-secreting pituitary adenoma associated with JAK2 V617F mutation. RESULTS: The patient shows primary thrombocythemia and myelofibrosis, due to JAK2 V617F mutation, severe visceromegaly and a peculiar clinical course of the disease characterized by discrepant values of GH and IGF-1 during somatostatin analog (SA) treatment despite a significant reduction in pituitary a…

The effects of physical training without equipment on pain perception and balance in the elderly: A randomized controlled trial

2017

BACKGROUND: Research supports a link between exercise and falls prevention in the older population. OBJECTIVES: Our aims were to evaluate pain perception and balance skills in a group of elderly subjects and to examine the consequences of a standardized equipment-free exercise program intervention on these variables. The study utilized a randomized controlled trial method. METHODS: 92 subjects were recruited from a rural Sicilian village (Resuttano, Sicily, Italy). Subjects were randomly split into two groups, an experimental group (EG; n = 49) and a control group (CG; n = 43). Qualified fitness instructors delivered the standardized physical exercise program for the EG whilst the CG did no…

Ex vivo T-cell depletion vs post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil as graft-vs-host disease prophylaxis for allogenei…

2021

Objective To compare the efficacy and safety of CD34+ selected ex vivo T-cell depletion (TCD) vs post-transplant cyclophosphamide, sirolimus, and mycophenolate mofetil (PTCy-Sir-MMF) as graft-vs-host disease (GVHD) prophylaxis. Methods We retrospectively included patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) with either TCD (n = 38) or PTCy-Sir-MMF (n = 91). Results Cumulative incidence of neutrophil and platelet recovery was 92% vs 99% (P = .06) and 89% vs 97% (P = .3) in TCD and PTCy-Sir-MMF, respectively. Cumulative incidences of aGHVD grade II-IV, III-IV, and moderate to severe cGVHD were 11% vs 19% (P = .2), 3% vs 2% (P = .9), and 3% vs 36% (P < …

Application of geomarketing to coastal tourism areas

2019

Geomarketing allows geographic units to be defined with a certain degree of homogeneity in terms of tourist preferences, behaviours, needs, expectations, buying and consumption patterns, and analogous attitudes. The result is a “territorial segmentation” of the demand in accordance with the geographic characteristics of tourism areas. The objective of this work is to analyse the strengths and weaknesses of applying geomarketing to the territorial segmentation of demand in coastal tourism areas. An empirical analysis of hotels specialising in family tourism in tourist accommodation establishments in Costa Adeje (Spain) is presented. The main conclusion is that the tourist accommodation varia…

Vadības zinātnes attīstība Latvijā: mūsdienās un nākotnē

2001

Krājumā ir aplūkotas aktuālās ekonomiskās un vadības problēmas Latvijā. Autoru pētītos jautājumus var iedalīt piecās grupās: finansu sfēras un kredītu attiecību attīstība, kā arī banku vadīšanas tendenču analīze; ar vidi un uzņēmējdarbības attīstību Latvijā saistīti jautājumi; Latvijas makroekonomiskās problēmas - darba tirgus funkcionēšana, iekšzemes kopprodukta dinamikas ietekmējošo faktoru analīze, privatizācijas procesa efektivitāte, stratēģiskās plānošanas loma un nozīme; mārketinga un menedžmenta jautājumi; interesantu aspektu analīze pašvaldību darbībā.

Ekonomika. 2

2003

Oferta y demanda en el mercado turístico homosexual: una propuesta de estrategias de intercambio para la mejora del marketing en el segmento

2007

-Marcelo.Royo@uv.es -M.Eugenia.Ruiz@uv.es La demanda turística homosexual presenta características diferenciales, y necesidades y motivaciones específicas a las que la gran mayoría de empresas del sector turístico no han sabido y/o podido responder. El presente trabajo trata de identificar los principales tipos de empresas u organizaciones que actúan en este mercado y que constituyen la oferta turística, definir las peculiaridades de la demanda turística homosexual en cuanto a sus necesidades y expectativas, y exponer una serie de estrategias de marketing, ya sea segmentación, posicionamiento o mezcla de marketing, a seguir por aquellas empresas del sector turístico que deseen orientarse ha…