Search results for "GWA"
showing 10 items of 94 documents
Sensitivity of the atmospheric temperature profile to the aerosol absorption in the presence of dust
2014
Abstract Radiative transfer simulations in the shortwave (SW) and longwave (LW) spectral regions have been carried out to investigate the time evolution of the atmospheric heating/cooling rates and their influence on the temperature profiles under different vertical distributions of the aerosol absorption. The case study is based on measurements made at Rome, Italy, on 20 June 2007, when a dust layer was present above the urban boundary layer (BL) and the column aerosol optical depth at 550 nm was about 0.37. Column-integrated aerosol optical depth and single scattering albedo, as well as vertical profiles of aerosol extinction and meteorological variables have been derived from observation…
Altitude-resolved shortwave and longwave radiative effects of desert dust in the Mediterranean during the GAMARF campaign: Indications of a net daily…
2015
Desert dust interacts with shortwave (SW) and longwave (LW) radiation, influencing the Earth radiation budget and the atmospheric vertical structure. Uncertainties on the dust role are large in the LW spectral range, where few measurements are available and the dust optical properties are not well constrained. The first airborne measurements of LW irradiance vertical profiles over the Mediterranean were carried out during the Ground-based and Airborne Measurements of Aerosol Radiative Forcing (GAMARF) campaign, which took place in spring 2008 at the island of Lampedusa. The experiment was aimed at estimating the vertical profiles of the SW and LW aerosol direct radiative forcing (ADRF) and …
Variability of the African convection centre as viewed by outgoing longwave radiation records and relationships with sea-surface temperature patterns
1995
International audience; The main African convection centre (ACC) is delimited by the 5"-square areas with outgoing longwave radiation less than 235 W m-' in the domain 17.5°N-17.5"S and 18"W-46"E. Four parameters (latitude and longitude of the centre of gravity, mean intensity, and extension) were analysed during the period June 1974 to December 1991. The relationships between the variability of the ACC and the main sea-surface temperature (SST) patterns were then studied. Correlation and composite analyses demonstrate that the first principal component of SST, representing mainly the variability of the eastern and the central tropical Pacific, is associated strongly with the extension and …
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis
2021
Background & aims: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. Methods: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). Results: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10-4, with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10-6; odds…
Breast cancer genome-wide association studies: there is strength in numbers.
2012
Breast cancer (BC) is a heterogeneous disease that exhibits familial aggregation. Family linkage studies have identified high-penetrance genes, BRCA1, BRCA2, PTEN and TP53, that are responsible for inherited BC syndromes. Moreover, a combination of family-based and population-based approaches indicated that genes involved in DNA repair, such as CHEK2, ATM, BRIP and PALB2, are associated with moderate risk. Therefore, all of these known genes account for only 25% of the familial aggregation cases. Recently, genome wide association studies (GWAS) in BC revealed single nucleotide polymorphisms (SNPs) in five novel genes associated to susceptibility: TNRC9, FGFR2, MAP3K1, H19 and lymphocyte-spe…
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia
2013
Author version made available in accordance with the publisher's policy.
Observations and snow model simulations of winter energy balance terms within and between different coniferous forests in Southern Boreal Finland
2015
Variation of canopy properties between different forest types is seldom taken into account in hydrological and climate models, and consideration of variation inside a forest is normally omitted. In this work, three data sets on near surface energy balance terms (incoming shortwave and longwave radiation; air and snow–soil interface temperatures) were collected in the southern boreal coniferous zone in Finland during three winters below different types of forest canopies. The aim was to evaluate the ability of a snow mass and energy balance model with a canopy module to reproduce the observed differences in below-canopy incoming radiations and snow–soil interface temperature. Clear differenc…
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23
2021
Abstract Aims Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause of systolic heart failure. Methods and results We conducted the largest genome-wide association study performed so far in DCM, with 2719 cases and 4440 controls in the discovery population. We identified and replicated two new DCM-associated loci on chromosome 3p25.1 [lead single-nucleotide polymorphism (SNP) rs62232870, P = 8.7 × 10−11 and 7.7 × 10−4 in the discovery and replication steps, respectively] and chromosome 22q11.23 (lead SNP rs7284877, P = 3.3 × 10−8 and 1.4 × 10−3 in the discovery and replication steps, respectively), while confirming two previously identif…
Observed changes in the life time and amplitude of the madden-julian oscillation associated with interannual ENSO sea surface temperature anomalies
2007
Abstract The Madden–Julian oscillation (MJO) is analyzed using the reanalysis zonal wind– and satellite outgoing longwave radiation–based indices of Wheeler and Hendon for the 1974–2005 period. The average lifetime of the MJO events varies with season (36 days for events whose central date occurs in December, and 48 days for events in September). The lifetime of the MJO in the equinoctial seasons (March–May and October–December) is also dependent on the state of El Niño–Southern Oscillation (ENSO). During October–December it is only 32 days under El Niño conditions, increasing to 48 days under La Niña conditions, with similar values in northern spring. This difference is due to faster eastw…
Influence of the Madden-Julian Oscillation on Southern African summer rainfall
2007
Rain-causing mechanisms over Southern Africa (south of 15˚S) involve both tropical and temperate dynamics. Most studies focused on the synoptical timescale, while the intraseasonal (20-120 days) variability has more been neglected to date. This study aims at determining whether the dominant mode of intraseasonal variability in the Tropics, namely the Madden-Julian Oscillation (MJO), has a significant impact on Southern African rainfall and associated atmospheric dynamics. The examination of outgoing longwave radiation (OLR) over Southern Africa shows indeed significant intraseasonal fluctuations at the 30-60 day timescale, i.e. in the pe- riods that are typically reminiscent of the MJO. In ord…