Search results for "GWA"

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

2011

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may p…

Hybrid CPU/GPU Acceleration of Detection of 2-SNP Epistatic Interactions in GWAS

2014

This is a post-peer-review, pre-copyedit version of an article published in Lecture Notes in Computer Science. The final authenticated version is available online at: https://doi.org/10.1007/978-3-319-09873-9_57 [Abstract] High-throughput genotyping technologies allow the collection of up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as 2-SNP interactions, in Genome-Wide Association Studies is an important but time consuming operation since statistical computations have to be performed for each pair of measured markers. In this work we present EpistSearch, a parallelized tool that, following the log-linear model appr…

How do tropical temperate troughs form and develop over southern Africa?

2014

16 pages ; Corrigendum Figure (Macron C, B Pohl, Y Richard & M Bessafi (2014) CORRIGENDUM. Journal of Climate, 27, 5198-5199. doi:10.1175/JCLI-D-14-00319.1); International audience; This paper aims at separating the respective influences of tropical and midlatitude variability on the development and life cycle of tropical temperate troughs (TTTs) over southern Africa in austral summer (November-February). Cluster analysis is applied to 1971-2000 40-yr ECMWF Re-Analysis (ERA-40) daily outgoing longwave radiation (OLR) anomalies to identify TTTs and monitor tropical convection. The same analysis applied to the zonal wind stretching deformation at 200 hPa (ZDEF) characterizes midlatitude trans…

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

2013

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10-14), 18q21.33 (BCL2, P = 7.76 × 10-11), 11p15.5 (C11orf21, P = 2.15 × 10 -10), 4q25 (LEF1, P = 4.24 × 10-10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10-9), 9p21.3 (CDKN2B-AS1, P = 1.27 × 10…

Comparison of Genome Wide Association Studies for milk production traits in Valle del Belice dairy sheep

The great achievements in livestock species selection during the last 50 years largely relied on quantitative genetic theory and infinitesimal genetic model. In the last 20 years, due to the application of advanced techniques in molecular genetics and statistics, several chromosomal regions that influence quantitative traits have been discovered. Combinations of molecular and classical quantitative information in a composite selection index have been proposed to increase the accuracy of selection. Nowadays, many genotyping arrays for thousands of SNPs are available for several livestock species, such as: cattle, sheep, pigs, horses, goat and chickens. The overall aim of this thesis is the c…

Genome-wide association study for milk production traits in Valle del Belice sheep

2017

Over the last years, high-throughput technologies have provided the opportunity to explore the genomes of livestock species to identify regions influencing traits of economic interest. Genome wide association studies (GWAS) have been widely used to disentangle the genetic variation in complex phenotypes, such as milk production traits in sheep. The study presented here investigated the possible association of genome-wide SNPs and breeding values for milk production traits in the Valle del Belice sheep. The studied population consisted of a total of 481 ewes belonging to 9 half-sib families with available records for milk yield (MY), protein and fat percentage (P% and F%, respectively). All …

Giuseppe Samonà e la “spina dorsale” di Gibellina Nuova

2020

Nel 1970 Giuseppe Samonà coordina il gruppo di progettazione formato da Vittorio Gregotti, Gianni Pirrone e Alberto Samonà per il Progetto del Centro civico, commerciale e culturale di Gibellina Nuova. Del piano è realizzato il municipio e poi, rielaborato e in altro luogo, il teatro. I monumenti, fondati su un asse pedonale in quota connesso a un suolo artificiale articolato, esprimono l’unità architettura – urbanistica e anticipano, per certi versi, una riflessione successiva del Direttore dello IUAV sulla dialettica fra urbano e rurale.

Outdoor Mean Radiant Temperature Estimation: Is the Black-Globe Thermometer Method a Feasible Course of Action?

2018

Urban planning has become one of the crucial action in order to address and mitigate the effect and the consequences of the global warming and it also entails different sectors of the urban context. The survey and control of the outdoor climatic conditions are among the involved sectors and mean radiant temperature is amid the most analyzed parameters. The aim of the paper is to investigate the effective suitability of one of the most used method in the assessment of the mean radiant temperature, namely the globe-thermometer method, in outdoor urban environment, singling out possible shortcomings and actual efficacy. Specifically, data obtained by measurement campaigns performed by means of…

How Important Are Genes to Achieve Longevity?

2022

Several studies on the genetics of longevity have been reviewed in this paper. The results show that, despite efforts and new technologies, only two genes, APOE and FOXO3A, involved in the protection of cardiovascular diseases, have been shown to be associated with longevity in nearly all studies. This happens because the genetic determinants of longevity are dynamic and depend on the environmental history of a given population. In fact, population-specific genes are thought to play a greater role in the attainment of longevity than those shared between different populations. Hence, it is not surprising that GWAS replicated associations of common variants with longevity have been few, if an…

GPU-accelerated exhaustive search for third-order epistatic interactions in case–control studies

2015

This is a post-peer-review, pre-copyedit version of an article published in Journal of Computational Science. The final authenticated version is available online at: https://doi.org/10.1016/j.jocs.2015.04.001 [Abstract] Interest in discovering combinations of genetic markers from case–control studies, such as Genome Wide Association Studies (GWAS), that are strongly associated to diseases has increased in recent years. Detecting epistasis, i.e. interactions among k markers (k ≥ 2), is an important but time consuming operation since statistical computations have to be performed for each k-tuple of measured markers. Efficient exhaustive methods have been proposed for k = 2, but exhaustive thi…