6533b829fe1ef96bd128a3d2
RESEARCH PRODUCT
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Arthur W. MuskArthur W. MuskErnst OmenaasDana B. HancockDana B. HancockJennie HuiJennie HuiJohn W. HollowayNora FranceschiniAlan F. WrightMa'en ObeidatJudith M. VonkNorman KloppShah EbrahimR. Graham BarrJerome I. RotterAlbert HofmanJennifer E. HuffmanKirsi H. PietiläinenJohn BeilbyBruno H. Ch. StrickerBruno H. Ch. StrickerXiangjun GuFernando RivadeneiraJames F. WilsonFredrik NybergFredrik NybergPeter D. SlyMaría Soler ArtigasBonnie R. JoubertMarjo-riitta JärvelinMedea ImbodenVeronique VitartAlbert V. SmithIda SurakkaIda SurakkaC.m. JacksonSusan R. HeckbertSusan R. HeckbertAvan Aihie SayerCraig E. PennellMatthias WjstIvana KolcicCyrus CooperWei AngIan SayersJohn BrittonGeorge T. O'connorGeorge T. O'connorPatrick G. HoltAnna-liisa HartikainenAdaikalavan RamasamyAdaikalavan RamasamyJing Hua ZhaoJonathan MarchiniBernd MeibohmLaura R. LoehrMark EijgelsheimDavid CouperMassimo ManginoSantosh DahgamVilmundur GudnasonDavid P. StrachanMartin D. TobinRebecca HardyNicole Probst-henschStephen B. KritchevskyGeorge Davey SmithTatijana ZemunikToby JohnsonSamuli RipattiSamuli RipattiGeorg HomuthDebbie A LawlorThor AspelundHenry VölzkeJohn M. StarrAroon D. HingoraniKhalid A. Al BalushiIvan CurjuricJohn HendersonDiana KuhRuth J. F. LoosJoachim HeinrichOzren PolasekYongmei LiuDirkje S. PostmaRaquel GranellAkshay SoodKari E. NorthBeate KochChristian GiegerTamara B. HarrisAnneli PoutaDavid J. PorteousDaan W. LothSarah H. WildGudny EiriksdottirMladen BobanMarkku HeliövaaraJonas BrismanMika KähönenEva AlbrechtPirro G. HysiPaul ElliottPaul ElliottStephanie J. LondonGuy BrusselleMyriam FornageThierry RochatKurt LohmanAni ManichaikulDavid M. EvansFlorian KronenbergCaroline HaywardHarry CampbellTricia M. MckeeverSo-youn ShinDeborah JarvisDeborah JarvisAlanna C. MorrisonNicole M. WarringtonNicole M. WarringtonHolger SchulzKaren A. JamesonStefan KarraschCisca WijmengaRichard W MorrisGauti Kjartan GislasonLina ZgagaLina ZgagaIvica GrkovićAlan JamesAlan JamesAmanda P. HenryO. Dale WilliamsJaakko KaprioJaakko KaprioGemma CadbyGemma CadbySusan M. RingPeter H WhincupThomas LumleyNicholas J. WarehamLorna M. LopezJohn L. HankinsonChristopher J HammondAndré G. UitterlindenIsabelle PinShona M. KerrAlicja R. RudnickaIan J. DearyTaina RantanenSven GläserSven GläserWendy L. McardleAndrew WongInês BarrosoIns BarrosoLenore J. LaunerS. Goya WannametheeWenbo TangIan P. HallSina A. GharibLouise V. WainVesna BoraskaJohn D BlakeyH.-erich WichmannAnna-carin OlinPatricia A. CassanoH. Marike BoezenStipan JankovićIgor RudanIgor RudanAndrew D. MorrisJason Z. LiuSarah E. HarrisClyde FrancksMichael HunterMichael HunterKristin D. MarcianteStephen S. RichDarya GaysinaBruce M. PsatyBruce M. PsatyMelinda C. AldrichMelissa E. GarciaJemma B. WilkTim D. SpectorLyle J. PalmerLyle J. PalmerGuangju ZhaiGuangju Zhaisubject
OncologyVital capacityPROTEINGenome-wide association studyBLOOD-PRESSUREVARIANTSPulmonary function testingPulmonary Disease Chronic Obstructive0302 clinical medicineEpidemiologyIMPUTATIONChild11 Medical and Health SciencesPOPULATIONGenetics & HeredityRISK0303 health scienceseducation.field_of_studyWOMENGENETIC-VARIATION3. Good healthRespiratory Function Testsmedicine.anatomical_structureMedical geneticsLife Sciences & BiomedicineEXPRESSIONmedicine.medical_specialtyMECOMPopulationEuropean Continental Ancestry GroupBiologyOBSTRUCTIVE PULMONARY-DISEASEArticleWhite People03 medical and health sciencesInternal medicineGeneticsmedicineHumanseducationMETAANALYSISPOLYMORPHISMS030304 developmental biologyLungScience & TechnologyMORTALITYGIANT consortiumInternational Lung Cancer Consortium06 Biological Sciences030228 respiratory systemImmunologylung; gene; gwasGenome-Wide Association StudyDevelopmental Biologydescription
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-11-01 | Nature Genetics |