Search results for "Gabaars"

showing 1 items of 1 documents

Fast Regulation of GABAAR Diffusion Dynamics by Nogo-A Signaling.

2019

Summary: Precisely controlling the excitatory and inhibitory balance is crucial for the stability and information-processing ability of neuronal networks. However, the molecular mechanisms maintaining this balance during ongoing sensory experiences are largely unclear. We show that Nogo-A signaling reciprocally regulates excitatory and inhibitory transmission. Loss of function for Nogo-A signaling through S1PR2 rapidly increases GABAAR diffusion, thereby decreasing their number at synaptic sites and the amplitude of GABAergic mIPSCs at CA3 hippocampal neurons. This increase in GABAAR diffusion rate is correlated with an increase in Ca2+ influx and requires the calcineurin-mediated dephospho…

0301 basic medicineHippocampal formationInhibitory postsynaptic potentialGeneral Biochemistry Genetics and Molecular BiologyArticleSynaptic plasticityDephosphorylation03 medical and health sciences0302 clinical medicineSingle Particle Trackingmental disordersEi BalanceVeröffentlichung der TU Braunschweiglcsh:QH301-705.5Loss functionExcitationS1pr2S1PR2ddc:5InhibitionChemistryQuantum dotsCalcineurinGabaarsNogo-A; S1PR2 ; EI balance ; calcineurin ; inhibition ; excitation ; quantum dots ; GABAARs ; synaptic plasticity ; single particle trackingddc:57030104 developmental biologylcsh:Biology (General)Synaptic plasticityExcitatory postsynaptic potentialGABAergicNogo-ANeurosciencepsychological phenomena and processes030217 neurology & neurosurgery
researchProduct