Search results for "Gamma"
showing 10 items of 3093 documents
Helicobacter pylori gamma-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance
2013
Infection with the gastric bacterial pathogen Helicobacter pylori is typically contracted in early childhood and often persists for decades. The immunomodulatory properties of H. pylori that allow it to colonize humans persistently are believed to also account for H. pylori ’s protective effects against allergic and chronic inflammatory diseases. H. pylori infection efficiently reprograms dendritic cells (DCs) toward a tolerogenic phenotype and induces regulatory T cells (Tregs) with highly suppressive activity in models of allergen-induced asthma. We show here that two H. pylori virulence determinants, the γ-glutamyl transpeptidase GGT and the vacuolating cytotoxin VacA, contribute critic…
A Trial of a Transglutaminase 2 Inhibitor in Celiac Disease. Reply.
2021
In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.
2010
The potent anti-tumour activities of gamma delta T cells have prompted the development of protocols in which gamma delta-agonists are administered to cancer patients. Encouraging results from small Phase I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a V gamma 9V delta 2 T cell agonist, plus low-dose interleukin (IL)-2 were administered to 10 therapeutically terminal, advanced metastatic breast cancer patients. Treatment was well tolerated and promoted the effector maturation of V gamma 9V delta 2 T …
Therapeutic Potential of Gammadelta T-Cells in Controlling CMV After Allogeneic Stem Cell Transplantation
2011
Longitudinal analysis of Mycobacterium tuberculosis 19-kDa antigen-specific T cells in patients with pulmonary tuberculosis: association with disease…
2003
CD8(+) T cells play a central role in immune protection against infection with Mycobacterium tuberculosis. One of the target epitopes for anti-M. tuberculosis directed CD8(+) T cells is the HLA-A2-restricted 19-kDa lipoprotein peptide VLTDGNPPEV. T cell clones directed against this epitope recognized not only the nominal peptide ligand, but also a closely related peptide (VPTDPNPPEV) from the HIV envelope gp120 (HIV(env) gp120) protein characterized by IFN-gamma release. This cross-reactivity was confirmed in ex vivo in M. tuberculosis 19-kDa tetramer-sorted T cells from patients with tuberculosis and in HIVgp120 tetramer-reactive T cells sorted from HIV(+) patients. M. tuberculosis 19-kDa …
Biology of gama delta T Cells in Tuberculosis and Malaria
2002
Tuberculosis and malaria remain the leading causes of mortality among human infectious diseases in the world. It is estimated that 3 to 5 million people die from tuberculosis and malaria each year. Although it is traditionally believed that CD4 and CD8 alphabeta T lymphocytes are mandatory for protective immune responses against Mycobacterium tuberculosis and Plasmodium falciparum (the ethiologic agents of tuberculosis and the most severe form of malaria, respectively), there is still incomplete understanding of the mechanisms of immune protection and of the causes of its failure in the affected patients. Several studies in humans and animal models have suggested that Vgamma9/Vdelta2 T cell…
IL-4 depletion enhances host resistance and passive IgA protection against tuberculosis infection in BALB/c mice.
2007
The influence of Th2 cytokines in tuberculosis has been a matter of dispute. Here we report that IL-4 has a profound regulatory effect on the infection of BALB/c mice with Mycobacterium tuberculosis. Depletion of IL-4 with a neutralizing mAb caused only evanescent reduction of lung infection, but when combined with i.n. inoculations of IgA anti-mycobacterial alpha-crystallin mAb and mouse rIFN-gamma, we observed a 40-fold reduction of the bacterial counts in the lungs at 3 wks following i.n. infection (p<0.001). In genetically deficient IL-4-/- BALB/c mice, infection in both lung and spleen was substantially reduced for up to 8 wks without further treatment. Reconstitution of IL-4-/- mice w…
Diseño e implementación de un SPECT pre-clínico basado en cristales continuos
2012
El trabajo de esta tesis consiste en el desarrollo y puesta en marcha de dos prototipos SPECT para animales pequeños utilizando la mini gammacámara desarrollada previamente por nuestro grupo de Física Médica. Se realiza en primer lugar una primera prueba de concepto con el objetivo de comprobar la viabilidad del proyecto, dicho prototipo se diseña y desarrollolla en el Servicio de Medicina Nuclear del Hospital Clínico y Provincial de Barcelona. En el segundo prototipo se pretende ampliar la prueba de concepto y desarrollar un nuevo prototipo con el que se obtenga un mayor rendimiento del SPECT con la misma gammacámara. Para ello, este prototipo dispone de 2 detectores montadas opuestas en e…
Relativistic Hydrodynamics and Spectral Evolution of GRB Jets
2017
En la presente tesis hemos estudiado los sistemas progenitores de las erupciones de rayos gamma (ERG, o GRBs por sus siglas en inglés --Gamma-Ray Bursts--) de larga duración mediante modelos numéricos de su evolución dinámica y emisión electromagnética. De todas las posibles clases de eventos, en particular nos centramos en aquellas que muestran una componente prominente de emisión térmica, la cual podría generarse por medio de la interacción de un chorro constituido por plasma relativista con el medio en el que se propaga. La parte central de esta tesis se ha dedicado al modelado de ERG a partir de dos clases diferentes de progenitores: ERG ultra largas dominadas en su espectro de emisión …
The exact distribution of a weighted Convolution of two Gamma distributions
2006
Si considera una rappresentazione della funzione di densit`a di probabilit`a di una Convoluzione ponderata di distribuzioni Gamma, in cui una funzione ipergeometrica confluente descrive come le differenze tra i parametri di scala delle componenti determinino allontanamenti da una densit`a Gamma. Si considera il caso specifico di una convoluzione di due variabili gamma per mostrare, come al vantaggio interpretativo si aggiunga la possibilit`a di derivare in forma esplicita e computazionalmente semplice, espressioni della funzione di ripartizione e dei momenti. Si mostra la relazione tra tale distribuzione ed il sistema delle distribuzioni di Bessel, e si generalizza inoltre al caso di convol…