Search results for "Gamma"

showing 10 items of 3093 documents

Cytomegalovirus‐specific T‐cell immunity and DNAemia in patients with chronic lymphocytic leukaemia undergoing treatment with ibrutinib

2021

CD4-Positive T-LymphocytesMaleCongenital cytomegalovirus infectionCytomegalovirusT-Cell Antigen Receptor SpecificityCD8-Positive T-LymphocytesViral Matrix Proteinschemistry.chemical_compoundPiperidinesT-Lymphocyte SubsetsT cell immunitymedicineHumansIn patientViremiaProtein Kinase InhibitorsAgedAged 80 and overLymphocytic leukaemiabusiness.industryAdenineHematologyCmv dnaemiaMiddle Agedmedicine.diseaseLeukemia Lymphocytic Chronic B-CellchemistryIbrutinibCytomegalovirus InfectionsDNA ViralImmunologyFemalebusinessInterferon-gamma Release TestsBritish Journal of Haematology
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Angioimmunoblastic T-cell lymphoma

2008

Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive neoplasm clinically characterized by sudden onset of constitutional symptoms, lymphadenopathy, hepatosplenomegaly, frequent autoimmune phenomena, particularly hemolytic anemia and thrombocytopenia, and polyclonal hypergammaglobulinemia. The lymph node histological picture is also distinctive, constituted by a polymorphic infiltrate, a marked proliferation of high endothelial venules, and a dense meshwork of dentritic cells. The neoplastic CD4+ T-cells represent a minority of the lymph node cell population; its detection is facilitated by the aberrant expression of CD10. Almost all cases arbor an EBV infected B-cell populatio…

CD4-Positive T-LymphocytesMaleEpstein-Barr Virus InfectionsPathologyAutologous transplantHerpesvirus 4 HumanHepatosplenomegalyImmunosuppressive AgentEpstein-Barr Virus InfectionHypergammaglobulinemiaLymph nodeNon-Hodgkin lymphomaAngioimmunoblastic lymphomaB-Lymphocyteseducation.field_of_studyB-LymphocyteLymph NodeHematologyThalidomideSurvival RateTransplantation Autologoumedicine.anatomical_structureOncologyCD4-Positive T-LymphocyteFemaleNeprilysinmedicine.symptomImmunosuppressive AgentsHumanmedicine.medical_specialtyAngioimmunoblastic T-cell lymphomaPopulationHigh endothelial venulesDendritic CellLymphoma T-CellTransplantation AutologousmedicineHumanseducationCell Proliferationbusiness.industryPeripheral T-cell lymphomaDendritic Cellsmedicine.diseasePeripheral T-cell lymphomaLymphomaTransplantationImmunologyLymph NodesGeriatrics and GerontologybusinessStem Cell Transplantation
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IFN-γ–Producing CD4+ T Cells Promote Generation of Protective Germinal Center–Derived IgM+ B Cell Memory against Salmonella Typhi

2014

Abstract Abs play a significant role in protection against the intracellular bacterium Salmonella Typhi. In this article, we investigated how long-term protective IgM responses can be elicited by a S. Typhi outer-membrane protein C– and F–based subunit vaccine (porins). We found that repeated Ag exposure promoted a CD4+ T cell–dependent germinal center reaction that generated mutated IgM-producing B cells and was accompanied by a strong expansion of IFN-γ–secreting T follicular helper cells. Genetic ablation of individual cytokine receptors revealed that both IFN-γ and IL-17 are required for optimal germinal center reactions and production of porin-specific memory IgM+ B cells. However, mor…

CD4-Positive T-LymphocytesMaleSalmonella VaccinesProtein subunitmedicine.medical_treatmentImmunologyCellBiologySalmonella typhiMicrobiologyInterferon-gammaMice03 medical and health sciences0302 clinical medicinemedicineAnimalsHumansImmunology and AllergyTyphoid FeverReceptorB cell030304 developmental biologyMice KnockoutB-Lymphocytes0303 health sciencesGerminal centerSalmonella typhiGerminal Center3. Good healthVaccinationmedicine.anatomical_structureCytokineImmunoglobulin MbacteriaFemaleImmunologic Memory030215 immunologyThe Journal of Immunology
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WHOLE BODY IRRADIATION INDUCES IFN-γ PRODUCTION IN BALB/c MICE BY PREVENTING THE APPEARANCE OF A Vα14+NK T DOWNREGULATORY POPULATION

2000

Lymph node cells from TNCB-immune BALB/c mice fail to produce IFN-gamma when exposed to antigen in vitro. Conversely, lymph node cells of irradiated (550 rads) BALB/c mice produce IFN-gamma. Transfer experiments show that normal BALB/c mice contain cells which suppress IFN-gamma production. These downregulatory cells are CD4(+)alpha beta(+)and rearrange the invariant V alpha 14-J alpha 281 T cell receptor alpha chain, thus belonging to the NK T cell subset. Downregulatory cells probably act by producing IL-4 as their effect is blocked by mAb to IL-4.

CD4-Positive T-LymphocytesMalemedicine.drug_classCD8 AntigensReceptors Antigen T-Cell alpha-betaImmunologyPopulationWhole body irradiationAntigen-Presenting CellsDown-RegulationAntigens ProtozoanEnzyme-Linked Immunosorbent AssayCell SeparationMonoclonal antibodyBiochemistryBALB/cInterferon-gammaMiceAntigenmedicineAnimalsImmunology and AllergyeducationMolecular BiologyLymph nodeLeishmania majorMice Inbred BALB Ceducation.field_of_studybiologyChemistryT-cell receptorAntibodies MonoclonalHematologyFlow Cytometrybiology.organism_classificationMolecular biologyIn vitroKiller Cells NaturalPhenotypemedicine.anatomical_structureCD4 AntigensImmunologyInterleukin-4Lymph NodesSpleenCytokine
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Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methot…

1999

SUMMARYImmunosuppressive therapy with methotrexate (MTX) has been established as effective treatment for patients with rheumatoid arthritis. To analyse the therapeutic potential and mechanisms of action of MTX, we determined serum cytokine levels and cytokine production by splenic T cells and macrophages in untreated and MTX-treated mice. Furthermore, we assessed the role of MTX in a murine model of experimental arthritis induced by collagen type II (CIA). MTX reduced spontaneous and IL-15-induced tumour necrosis factor (TNF) production by splenic T cells but not by macrophages from healthy mice in vitro in a dose-dependent manner. In contrast, interferon-gamma (IFN-γ) production was less s…

CD4-Positive T-LymphocytesMalemusculoskeletal diseasesT-Lymphocytesmedicine.medical_treatmentImmunologyArthritisMice TransgenicSpleenInterferon-gammaMiceImmune systemAnimalsImmunology and AllergyMedicineheterocyclic compoundsInterferon gammaskin and connective tissue diseasesInterleukin 4Interleukin-15Mice KnockoutMice Inbred BALB CInterleukin-6Tumor Necrosis Factor-alphabusiness.industryMacrophagesOriginal ArticlesImmunotherapymedicine.diseaseArthritis ExperimentalMethotrexatemedicine.anatomical_structureCytokineMice Inbred DBAImmunologyCytokinesTumor necrosis factor alphaCollagenInterleukin-4businessImmunosuppressive AgentsSpleenmedicine.drug
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Impaired immune response to Candida albicans in aged mice

2006

The prevalence of opportunistic fungal infections has increased dramatically among the aged population in recent years. This work investigated the effect of ageing on murine defences against Candida albicans. Aged C57BL/6 mice that were experimentally infected intravenously had a significantly impaired survival and a higher tissue fungal burden compared with young mice. In vitro production of tumour necrosis factor (TNF)-α by macrophages from aged mice in response to yeast cells and hyphae of C. albicans was significantly lower than production by macrophages from young mice. In vitro production of cytokines, such as TNF-α and gamma interferon (IFN-γ), by antigen-stimulated splenocytes from …

CD4-Positive T-LymphocytesMicrobiology (medical)AgingNecrosisBlotting WesternHyphaeMicrobiologyMicrobiologyInterferon-gammaMiceImmune systemAntigenCandida albicansmedicineAnimalsCandida albicansAntibodies FungalCells CulturedbiologyTumor Necrosis Factor-alphaVaccinationCandidiasisGeneral Medicinebiology.organism_classificationAcquired immune systemCorpus albicansMice Inbred C57BLImmunoglobulin GInjections IntravenousImmunologyMacrophages Peritonealbiology.proteinFemaleTumor necrosis factor alphaDisease SusceptibilityFungal Vaccinesmedicine.symptomAntibodySpleenJournal of Medical Microbiology
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Functionalized Polystyrene Nanoparticles Trigger Human Dendritic Cell Maturation Resulting in Enhanced CD4+T Cell Activation

2012

Nanoparticles (NP) represent a promising tool for biomedical applications. Here, sulfonate- and phosphonate-functionalized polystyrene NP are analyzed for their interaction with human monocyte-derived dendritic cells (DC). Immature dendritic cells (iDC) display a higher time- and dose-dependent uptake of functionalized polystyrene NP compared to mature dendritic cells (mDC). Notably, NP induce an enhanced maturation of iDC but not of mDC (upregulation of stimulatory molecules and cytokines). NP-triggered maturation results in a significantly enhanced T cell stimulatory capacity (increased CD4(+) T cell proliferation and IFN-γ production), indicating a shift to a pronounced Th1 response. Imm…

CD4-Positive T-LymphocytesPolymers and Plasticsmedicine.medical_treatmentT cellOrganophosphonatesNanoparticleBioengineeringLymphocyte ActivationFunctionalized polystyreneBiomaterialsInterferon-gammachemistry.chemical_compoundDownregulation and upregulationMaterials ChemistrymedicineHumansImmunologic FactorsMicroscopy ConfocalCd4 t cellChemistryDendritic CellsImmunotherapyDendritic cellCell biologymedicine.anatomical_structureImmunologyCytokinesNanoparticlesPolystyrenesPolystyreneSulfonic AcidsBiotechnologyMacromolecular Bioscience
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Regulation of Protein-DNA Interactions at the Interferon-gamma Gene Promoter by Corticosteroids: Implications for Inflammatory Bowel Diseases

1998

CD4-Positive T-LymphocytesRecombinant Fusion ProteinsProtein dnaInterferon-gamma biosynthesisTransfectionGeneral Biochemistry Genetics and Molecular BiologyInterferon-gammaHistory and Philosophy of ScienceAdrenal Cortex HormonesGenes ReporterT-Lymphocyte SubsetsmedicineHumansInterferon gammaPromoter Regions GeneticGenebusiness.industryGeneral NeuroscienceInflammatory Bowel DiseasesPromoterTransfectionInflammatory Bowel DiseasesTranscription Factor AP-1ImmunologyLeukocyte Common AntigensCancer researchLeukocyte Common Antigensbusinessmedicine.drugAnnals of the New York Academy of Sciences
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Cytokine profile, HLA restriction and TCR sequence analysis of human CD4+ T clones specific for an immunodominant epitope of Mycobacterium tuberculos…

2003

SUMMARY The identification of immunodominant and universal mycobacterial peptides could be applied to vaccine design and have an employment as diagnostic reagents. In this paper we have investigated the fine specificity, clonal composition and HLA class II restriction of CD4+ T cell clones specific for an immunodominant epitope spanning amino acids 91–110 of the 16-kDa protein of Mycobacterium tuberculosis. Twenty-one of the tested 28 clones had a Th1 profile, while seven clones had a Th0 profile. None of the clones had a Th2 profile. While the TCR AV gene usage of the clones was heterogeneous, a dominant TCR BV2 gene family was used by 18 of the 28 clones. The CDR3 regions of BV2+ T cell c…

CD4-Positive T-LymphocytesSequence analysisT cellImmunologyReceptors Antigen T-CellEpitopeInterferon-gammaAntigenClinical StudiesmedicineHumansTuberculosisImmunology and AllergyGene familyGeneCells CulturedGeneticsAntigens BacterialbiologyImmunodominant EpitopesT-cell receptorHLA-DR AntigensMycobacterium tuberculosisComplementarity Determining RegionsPeptide Fragmentsmedicine.anatomical_structureImmunologybiology.proteinCytokinesAntibodyClinical and Experimental Immunology
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Highly focused T cell responses in latent human pulmonary Mycobacterium tuberculosis infection.

2005

Abstract The elucidation of the molecular and immunological mechanisms mediating maintenance of latency in human tuberculosis aids to develop more effective vaccines and to define biologically meaningful markers for immune protection. We analyzed granuloma-associated lymphocytes (GALs) from human lung biopsies of five patients with latent Mycobacterium tuberculosis (MTB) infection. MTB CD4+ and CD8+ T cell response was highly focused in the lung, distinct from PBL, as assessed by TCR-CDR3 spectratyping coupled with a quantitative analysis of TCR VB frequencies. GALs produced IFN-γ in response to autologous macrophages infected with MTB and to defined MTB-derived HLA-A2-presented peptides Ag…

CD4-Positive T-LymphocytesT cellReceptors Antigen T-Cell alpha-betaImmunologyAntigen presentationMolecular Sequence DataEpitopes T-Lymphocytechemical and pharmacologic phenomenaBiologyCD8-Positive T-LymphocytesEpitopeMycobacterium tuberculosisInterferon-gammaAntigenBacterial ProteinsMHC class IHLA-A2 AntigenmedicineImmunology and AllergyHumansAmino Acid SequenceTuberculosis PulmonaryAntigen PresentationAntigens BacterialGranulomaMacrophagesT-cell receptorMycobacterium tuberculosisTh1 Cellsbacterial infections and mycosesbiology.organism_classificationVirologyPeptide FragmentsClone Cellsmedicine.anatomical_structureReceptor-CD3 Complex Antigen T-CellImmunologybiology.proteinCytokinesCD8Protein BindingJournal of immunology (Baltimore, Md. : 1950)
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