Search results for "Gate"
showing 10 items of 1811 documents
Zofenopril is a cost-effective treatment for patients with left ventricular systolic dysfunction following acute myocardial infarction: a pharmacoeco…
2013
Objective: The Survival of Myocardial Infarction Long-term Evaluation 4 Study (SMILE-4) showed the superiority of Zofenopril (Z) associated with Acetylsalicylic Acid (ASA) as respect to Ramipril (R) plus ASA in reducing the occurrence of major cardiovascular events, in patients with left ventricular dysfunction (LVD) following Acute Myocardial Infarction (AMI). The objective of this retrospective analysis was the evaluation of cost-effectiveness of Z compared to R. Methods: 771 patients with LVD and AMI were randomized, double-blind to Z 60 mg/day (n=389) or R 10 mg/day (n=382) plus ASA 100 mg/day and followed-up for 1 year. The primary study end-point was 1-year combined occurrence of deat…
Modeling Information Processing Using Nonidentical Coulomb Blockade Nanostructures
2017
In recent years, molecular-protected metallic nanoparticles (NPs) have attracted a great deal of attention. Because of their reduced size, they behave like tiny capacitors so that there is an energy penalty when adding an electron to the NP which suppresses the electric current at a potential lower than a threshold value. This phenomenon is known as Coulomb blockade (CB) and allows the transport of electrons to be modulated through an external gate provided that the energy penalty is higher than the thermal energy. Together with the possibility of tailoring their properties, molecular protected NPs are potential candidates as future components of high density, low consumption electronics. H…
Generation of Hardware/Software systems based on CAL dataflow description
2011
International audience; This paper presents a new development of rapid prototyping tools for system design based on data-flow specifications. In this context, the efficiency of tools for the automatic translation from the data-flow programs to C and/or HDL are assessed by means of two design cases. The paper also introduces the new concept of the automatic synthesis of interfaces. Such generic interfaces are implemented by using an embedded microprocessor, which can support a large variety of interfaces already available as native IP libraries in the case of FPGA. The two design cases described here have been developed, tested and validated on different implementation platforms. The results…
Rapid prototyping platform for stream-oriented reconfigurable computing applications
2010
In this paper we present a methodology and tool for rapid prototyping of real time image processing applications. We describe our design flow of multiprocessor system on chip (MPSoC) architectures based on hardware/software components. This methodology provides automated methods to specify, generate the hardware, software, and the architectural interfaces between them. Our methodology starts from system level specification of the application with parallel processes described in C-code. The processes communicate through an abstract channel called streams. We describe also the solution that we proposed to synthesize a custom bus architecture for the reconfigurable computing applications, whic…
Actinopathies and Myosinopathies
2009
The currently recognized two forms of "anabolic" protein aggregate myopathies, that is, defects in development, maturation and final formation of respective actin and myosin filaments encompass actinopathies and myosinopathies. The former are marked by mutations in the ACTA1 gene, largely of the de novo type. Aggregates of actin filaments are deposited within muscle fibers. Early clinical onset is often congenital; most patients run a rapidly progressive course and die during their first 2 years of life. Myosinopathies or myosin storage myopathies also commence in childhood, but show a much more protracted course owing to mutations in the myosin heavy chain gene MYH7. Protein aggregation co…
Unexpected metal-free synthesis of trifluoromethyl arenes via tandem coupling of dicyanoalkenes and conjugated fluorinated sulfinyl imines
2021
A novel strategy for the synthesis of policyclic trifluoromethyl arenes has been devised. It involves a DBU-promoted tandem cycloaromatization reaction of dicyanoalkenes and fluorinated conjugated sulfinyl imines. This unprecedented transformation is a metal-free and air-tolerant process that takes place from readily available starting materials under mild reaction conditions.
Dataset of a globally relevant stock of soil nitrogen in the Yedoma permafrost domain
2022
This dataset merges nitrogen data from the Yedoma domain. It includes numerous fieldwork campaigns, which take place since 1998. In total 467 samples from the active layer (seasonally thawed layer), 175 samples from perennially frozen Holocene cover deposits, 479 samples from thermokarst deposits in drained thermokarst, 175 in-situ thawed, diagenetically (anaerobic microbial decomposition possible during unfrozen phase) altered Yedoma deposits (called Taberite), and 917 samples from frozen Yedoma deposits are included. Moreover it includes a NH4+ and NO3- quantification basing on of 658 samples, including 378 data points for NH4+ (active layer, 93; Holocene cover, 108; thermokarst sediment,…
A simple method for measurement of mechanical power in jumping.
1983
A simple test for the measurement of mechanical power during a vertical rebound jump series has been devised. The test consists of measuring the flight time with a digital timer (+/- 0.001 s) and counting the number of jumps performed during a certain period of time (e.g., 15-60 s). Formulae for calculation of mechanical power from the measured parameters were derived. The relationship between this mechanical power and a modification of the Wingate test (r = 0.87, n = 12 males) and 60 m dash (r = 0.84, n = 12 males) were very close. The mechanical power in a 60 s jumping test demonstrated higher values (20 W X kgBW-1) than the power in a modified (60 s) Wingate test (7 W X kgBW-1) and a Mar…
Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: A European consensus position paper
2015
While they account for one-fifth of new cancer cases, rare cancers are difficult to study. A higher than average degree of uncertainty should be accommodated for clinical as well as for population-based decision making. Rules of rational decision making in conditions of uncertainty should be rigorously followed and would need widely informative clinical trials. In principle, any piece of new evidence would need to be exploited in rare cancers. Methodologies to explicitly weigh and combine all the available evidence should be refined, and the Bayesian logic can be instrumental to this end. Likewise, Bayesian-design trials may help optimize the low number of patients liable to be enrolled in …
Price Impact Function of a Single Transaction
2004
Although supply and demand are perhaps the most fundamental concepts in economics, finding any general form for their behavior has proved to be elusive. Here we discuss our recent findings [1] on the price impact function empirically detected in the New York Stock Exchange (NYSE). Our study builds on earlier studies of how trading affects prices [2, 3, 4, 5, 6, 7, 8, 9, 10, 11]. In particular, we look at the short term response to a single trade. This is done by using huge amounts of data and by measuring the market activity in units of transactions rather than seconds, so that we can more naturally aggregate data for many different stocks. This allows us to find regularities in the respons…