Search results for "Gel"
showing 10 items of 3561 documents
Sleep disturbances in Algelman syndrome: a questionnaire study
2004
Only few studies are available on sleep disorders in Angelman syndrome (AS), a neurodevelopmental disorder with several behavior disturbances. The aim of this study was to determine the prevalence of sleep disorders in a relatively large group of AS subjects, compared to that of age-matched controls. Fourty-nine consecutive parents of patients with AS (26 males and 23 females aged 2.3–26.2 years) were interviewed and filled out a comprehensive sleep questionnaire. Based on their genetic etiology, four groups were defined: deletion of chromosome 15q11–13 (25 subjects); methylation imprinting mutation (six subjects), UBE3A mutations (seven subjects) and paternal uniparental disomy (five subje…
I Vaticana fragmenta a due secoli dalla riscoperta
2022
Two centuries have passed since the palimpsest that transmits a Roman legal work known as the Vaticana fragmenta was rediscovered by Angelo Mai in the Vatican Apostolic Library in Rome. This paper reviews the main issues relating to this work and suggests some reasons why a new edition of the text is desirable. 1820 hat Angelo Mai in der Vatikanischen Apostolischen Bibliothek in Rom ein Palimpsest wiederentdeckt, welches ein römisches Rechtswerk – die so genannte Vaticana Fragmenta – überliefert. 200 Jahre sind seitdem genau vergangen. Dieser Beitrag gibt einen Überblick über die wichtigsten Aspekte dieses Werks und zeigt Gründe auf, warum eine neue Ausgabe dieses Textes wünschenswert ist.
Recensione ad Angelo Poliziano, Greek and Latin Poetry, edited and translated by P.E. Knox, Cambridge [Mass.]-London, Harvard University Press, 2018,…
2021
Recensione ad Angelo Poliziano, Greek and Latin Poetry, edited and translated by P.E. Knox, Cambridge [Mass.]-London, Harvard University Press, 2018. Si tratta dell'edizione, criticamente rivista, con introduzione, traduzione inglese a fronte e commento, di tutta la produzione poetica greca e latina del Poliziano. Il volume è stato pubblicato nel 2018 all'interno della serie The I Tatti Renaissance Library. Review to Angelo Poliziano, Greek and Latin Poetry, edited and translated by P.E. Knox, Cambridge [Mass.] - London, Harvard University Press, 2018. This is the critically revised edition, with introduction, English translation and commentary, of all of Poliziano's Greek and Latin poetry.…
«L’antico come principio di nuova architettura». Il tempo perenne delle opere e dei progetti
2022
Nonostante la raccolta degli scritti e dei progetti di Angelo Torricelli copra un arco temporale di oltre trent’anni (dal 1990 al 2021) essa costituisce una straordinaria narrazione coerente e coesa nella quale si ha chiara la sensazione di come l’oggetto della riflessione sia la connaturata dimensione sincronica dell’architettura tesa a essere, inevitabilmente, espressione di valori atemporali. Non a caso i titoli dei testi di Torricelli, ad iniziare da ciò che ne costituisce la sintesi suprema, l’espressione metonimica per eccellenza — "Il momento presente del passato" — tendono ad essere quasi dei voluti emblematici ossimori. Nella lettura interpretativa dell’antico in architettura propo…
Priming with proangiogenic growth factors and endothelial progenitor cells improves revascularization in linear diabetic wounds
2014
In the present study, we investigated whether proangiogenic growth factors and endothelial progenitor cells (EPCs) induce favourable effects on cutaneous incisional wound healing in diabetic mice. The proangiogenic effects of human EPCs were initially analyzed using a HUVEC in vitro angiogenesis assay and an in vivo Matrigel assay in nude mice (n=12). For the diabetic wound model, 48 Balb/c mice with streptozotocin (STZ)-induced diabetes were divided randomly into 4 groups (12 mice in each group). Subsequently, 3, 5 and 7 days before a 15-mm full-thickness incisional skin wound was set, group 1 was pre-treated subcutaneously with a mixture of vascular endothelial growth factor (VEGF)/basic …
Surface charge fine tuning of reversed-phase/weak anion-exchange type mixed-mode stationary phases for milder elution conditions.
2015
A series of new mixed-mode reversed-phase/weak anion-exchange (RP/WAX) phases have been synthesized by immobilization of N-undecenyl-3-α-aminotropane onto thiol-modified silica gel by thiol-ene click chemistry and subsequent introduction of acidic thiol-endcapping functionalities of different type and surface densities. Click chemistry allowed to adjust a controlled surface concentration of the RP/WAX ligand in such a way that a sufficient quantity of residual thiols remained unmodified which have been capped by thiol click with either 3-butenoic acid or allylsulfonic acid as co-ligands. In another embodiment, performic acid oxidation of N-undecenyl-3-α-aminotropane-derivatized thiol-modifi…
Thermo-responsive hydrogels from cellulose-based polyelectrolytes and catanionic vesicles for biomedical application.
2016
In this study, negatively charged catanionic vesicles/hydrophobically modified hydroxyethylcellulose polymers thermo-responsive hydrogels have been fabricated. Vesicular aggregates were found to act as multifunctional junctions for networking of modified-cellulose water solutions. The contributions of the electrostatic and hydrophobic interactions were evaluated by changing either vesicles composition or the polymer hydrophobic substitution. Thermal-induced size and lamellarity of hydrogel-enclosed vesicles were detected, with further polygonal shape changes induced by cellulose-based polymer addition. The thermal transition was also found to tune hydrogel mechanical behaviour. The network …
Dones i ciència. Quatre pioneres en el camp de la psicologia
2012
Una carrera científica normalment és una carrera d'obstacles, però en el cas de ser una dona s’afegeixen problemes i mecanismes d'exclusió específics. Per tal de conèixer les estratègies utilitzats per superar alguns obstacles, al present article revisem les biografies de quatre psicòlogues que, entre 1890 i 1940, van intentar obtenir una formació acadèmica i van aconseguir fer una contribució pròpia a la ciència psicològica.
Pyrano[2,3-e]isoindol-2-ones, new angelicin heteroanalogues
2009
A convenient synthesis of the pyrano[2,3-e]isoindol-2-one ring system, an heteroanalogue of angelicin, is reported. Our synthetic approach consists of the annelation of the pyran ring on the isoindole moiety using 5-dialkylamino- or 5-hydroxymethylene intermediates as building blocks. The photoantiproliferative activity of the new derivatives was studied. Some of them bearing the benzyl group at the 8 position were active with IC(50) in the micromolar range. Cell cytotoxicity involves apoptosis, alteration of cell cycle profile and membrane photodamage.
Characterization of liver cytokeratin as a major target antigen of anti-SLA antibodies.
1990
Abstract Anti-SLA antibodies characterize a newly defined subgroup of patients with autoimmune chronic active hepatitis. The aim of the present study was the immunochemical characterization of the target antigen(s) of anti-SLA antibodies. Anti-SLA-positive sera were found to contain high titres of anti-cytokeratin antibodies. In immunoblotting analyses with 100 000 × g supernatants of human liver homogenates (S-100) these sera recognized various proteins with a molecular mass of 40–60 kDa. These proteins were also recognized by monoclonal anti-cytokeratin antibodies. Two-dimensional co-electrophoresis and immunoblotting analysis of S-100 and liver cytokeratins showed that anti-SLA antibodie…