Search results for "Gels"
showing 10 items of 671 documents
Agarose/k-Carrageenan-based hydrogel films enriched with natural extracts for wound healing applications
2019
Hydrogels are 3D hydrophilic networks that can hold significant amounts of water within their structure, without dissolving in water. They can offer a combination of favorable properties, including high absorbency of biological fluids, biocompatibility, biodegradability, stimuli-responsiveness, high storage capacity and release ability of small and large therapeutic molecules. The hydrogel films designed for wound dressing may accomplish several functions, playing an important role in the healing processes. They can absorb and retain the wound exudates, stimulating fibroblast proliferation and keratinocyte migration and promoting re-epithelialization. Furthermore, they can incorporate and r…
Insulin Nanogels: a New Strategy for the Treatment of Alzheimer’s Disease
2016
A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signaling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer’s disease (AD) degeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim we have designed, synthesized and characterized a nanogel system (NG) to deliver insulin to the brain, as a tool for the development of a new therapy for AD. A carboxyl-functionalized poly(N-vinyl pyrrolidone) nanogel system produced by ionizing radiation was chosen as substrate for the covalent attachment of insulin or fluorescent molecules relevant for its characterization. Biocompatibility of the naked c…
NANOGELS AS USEFUL TOOL FOR ALZHEIMER’S DISEASE THERAPY
2014
High-energy radiation process, a "facile" and "versatile" approach to obtain PVP-graft- AA nanogels
2012
Poly(N-vinylpyrrolidone)-grafted-acrylic acid biocompatible nanogels (NGs) were prepared using an exiting industrial-type electron accelerator and setups, starting from semi-dilute aqueous solutions of a commercial PVP and the acrylic acid monomer. As a result, NGs with tunable size and structure can be obtained quantitatively. Sterility was also imparted at the integrated dose absorbed. The chemical structure of the NGs produced was confirmed through Fourier Transformer Infrared Spectroscopy (FT-IR). The molecular and physico-chemical properties of NGs, such as the hydrodynamic dimensions and surface charge densities, for various polymer and monomer concentrations in the irradiated solutio…
Injectable hydrogel formulations to host adipose stem cell spheroids for stemness maintenance and bone and cartilage regeneration
2021
Adipose-derived mesenchymal stem cells (ASCs) represent a great promise for tissue regeneration as fat is a very abundant source of stem cells (1) and owing to their ability to self-renew and differentiate into specific tissue types (2). In general, they are usually cultured as two-dimensional (2D) adherent monolayers, not representative of the in vivo condition, often entailing lower cell viability and, more in general, a lower “cell quality” in terms of regenerative potential (3, 4). When ASCs are cultured in low adhesion flasks and with a suitable culture medium, they aggregate in the form of three-dimensional spheroids (SASCs). The incorporation of these spheroids into injectable, in-si…
Nose-to-brain delivery of insulin enhanced by radiation-engineered nanogels
2018
Recent evidences suggest thet insulin delivery to the brain can be an important pharmacological therapy for some neurodegenerative pathologies, including Alzheimer disease (AD)