Search results for "Generation"
showing 10 items of 3050 documents
"Acc_MultiBin1" of "Search for bottom-squark pair production in $pp$ collision events at $\sqrt{s} = 13$ TeV with hadronically decaying $\tau$-lepton…
2021
Acceptance in the Multi-bin SR, $\min_{\Theta} < 0.5$ bin as a function of the M(Sbottom) vs. M(N2) with the $\Delta M$(N2,N1) = 130 GeV. Keep in mind that the acceptance is given in units of $10^{-4}$.
"Cutflow" of "Search for bottom-squark pair production in $pp$ collision events at $\sqrt{s} = 13$ TeV with hadronically decaying $\tau$-leptons, $b$…
2021
Cutflows for the bechmarl signal point M(Sbottom) = 800 GeV, M(N2) = 180 GeV. Weighted event yields are reported starting with the "Preselection" line, normalized to an integrated luminosity of $139$ fb$^{−1}$.
"PullPlots" of "Search for bottom-squark pair production in $pp$ collision events at $\sqrt{s} = 13$ TeV with hadronically decaying $\tau$-leptons, $…
2021
Comparison of the expected and observed event yields in the signal regions. The top-quark and Z(mumu) background contributions are scaled with the normalization factors obtained from the background-only fit. The other contribution includes all the backgrounds not explicitly listed in the legend (V+jets except Z(mumu)+jets, di-/triboson, multijet). The hatched band indicates the total statistical and systematic uncertainties in the SM background. The contributions from three signal models to the signal regions are also displayed, where the masses M(Sbottom) and M(N2) are given in GeV in the legend. The lower panel shows the significance of the deviation of the observed yield from the expecte…
Porous biomaterials and scaffolds for tissue engineering
2019
In the present article, an overview of the definition of tissue engineering and scaffold requirements is reported. In particular, scaffold porosity and its relevance for several tissue target regeneration is highlighted. Different scaffold fabrication techniques are reported and explained in details, highlighting advantages and disadvantages for all of these techniques, regarding the specific final applications.
Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher …
2006
Usher syndrome (USH) is the most frequent cause of combined deaf-blindness in man. It is clinically and genetically heterogeneous and at least 12 chromosomal loci are assigned to three clinical USH types, namely USH1A-G, USH2A-C, USH3A (Davenport, S.L.H., Omenn, G.S., 1977. The heterogeneity of Usher syndrome. Vth Int. Conf. Birth Defects, Montreal; Petit, C., 2001. Usher syndrome: from genetics to pathogenesis. Annu. Rev. Genomics Hum. Genet. 2, 271-297). Mutations in USH type 1 genes cause the most severe form of USH. In USH1 patients, congenital deafness is combined with a pre-pubertal onset of retinitis pigmentosa (RP) and severe vestibular dysfunctions. Those with USH2 have moderate to…
The Usher syndrome 1G protein SANS participates in the transport of ciliary cargo in photoreceptor cells
2012
Human Usher syndrome (USH) is the most common form of combined deaf-blindness, characterized by profound congenital deafness, constant vestibular dysfunction and pre-pubertal onset of retinitis pigmentosa. The USH1G protein SANS (scaffold protein containing ankyrin repeats and SAM domain) is associated with microtubules and mediates a transport related periciliary protein network in photoreceptor cells. Here we aim to enlighten the involvement of SANS in ciliary transport of photoreceptor cells by identifying proteins associated with SANS in transport complexes. In Y2H screen of retinal cDNA library we identified the direct binding of SANS to dynactin-1 (p150Glued), a subunit of the dynacti…
Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina
2011
Contains fulltext : 96822.pdf (Publisher’s version ) (Closed access) The human Usher syndrome (USH) is the most frequent cause of combined hereditary deaf-blindness. USH is genetically heterogeneous with at least 11 chromosomal loci assigned to 3 clinical types, USH1-3. We have previously demonstrated that all USH1 and 2 proteins in the eye and the inner ear are organized into protein networks by scaffold proteins. This has contributed essentially to our current understanding of the function of USH proteins and explains why defects in proteins of different families cause very similar phenotypes. We have previously shown that the USH1G protein SANS (scaffold protein containing ankyrin repeat…
Channeled scaffolds implanted in adult rat brain.
2012
Scaffolds with aligned channels based on acrylate copolymers, which had previously demonstrated good com- patibility with neural progenitor cells were studied as coloniz- able structures both in vitro with neural progenitor cells and in vivo, implanted without cells in two different locations, in the cortical plate of adult rat brains and close to the subven- tricular zone. In vitro, neuroprogenitors colonize the scaffold and differentiate into neurons and glia within its channels. When implanted in vivo immunohistochemical analysis by confocal microscopy for neural and endothelial cells markers demonstrated that the scaffolds maintained continuity with the surrounding neural tissue and wer…
GENERATION OF PREVASCULARIZED PLLA BIODEGRADABLE SCAFFOLDS BY DIP DRAWING AND DIFFUSION INDUCED PHASE SEPARATION (DIPS).
2009
A critical obstacle in tissue engineering is to develop a massive structure of living cells upon transfer from the in vitro culture conditions into the host in vivo. A vascular network is required to supply essential nutrients, including oxygen, remove metabolic waste products and provide a biochemical communication “highway”. For these reasons to build an implantable structure in which vessel formation (angiogenesis) take place is mandatory. PLLA scaffolds usable in vascular tissue engineering were generated by dip-coating via Diffusion Induced Phase Separation (DIPS) technique. The scaffolds, with a vessel-like shape, were obtained by performing a DIPS process around a nylon fibre whose d…
The use of hydrogels in bone-tissue engineering
2010
Many different types of scaffold materials have been used for tissue engineering applications, and hydrogels form one group of materials that have been used in a wide variety of applications. Hydrogels are hydrophilic polymer networks and they represent an important class of biomaterials in biotechnology and medicine because many hydrogels exhibit excellent biocompatibility with minimal inflammatory responses and tissue damage. Many studies have demonstrated the use of hydrogels in bone-tissue engineering applications. In this report, the summary was conducted on various kinds of polymers and different modification methods of hydrogels to enhance bone formation. The results revealed that hy…