Search results for "Generation"
showing 10 items of 3050 documents
Venerari Contendere Adicere: Roman Emulation, Intergenerational Reciprocity, and the Ancient Idea of Progress
2019
Over the past few decades, the successful emergence of intertextuality, with its careful investigation of the dynamics of imitation, allusion, and emulation, has effectively challenged the Romantic notions of creativity and individual authorship. In the wide-open field left by the postmodern ‘death of the author’, however, the territory of culture as a network of patterns hiding behind the text has often been restricted within the boundaries of literary culture. In this paper, I will attempt to enlarge such a text-centred perspective by highlighting the often neglected connections between family education, intergenerational reciprocity, and aesthetic thought in Roman culture. Indeed, long b…
Regulation of the p19(Arf)/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice.
2015
Brain aging is associated with increased neurodegeneration and reduced neurogenesis. B1/neural stem cells (B1-NSCs) of the mouse subependymal zone (SEZ) support the ongoing production of olfactory bulb interneurons, but their neurogenic potential is progressively reduced as mice age. Although age-related changes in B1-NSCs may result from increased expression of tumor suppressor proteins, accumulation of DNA damage, metabolic alterations, and microenvironmental or systemic changes, the ultimate causes remain unclear. Senescence-accelerated-prone mice (SAMP8) relative to senescence-accelerated-resistant mice (SAMR1) exhibit signs of hastened senescence and can be used as a model for the stud…
Imbalance between sympathetic and sensory innervation in peritoneal endometriosis
2011
To investigate possible mechanisms of pain pathophysiology in patients with peritoneal endometriosis, a clinical study on sensory and sympathetic nerve fibre sprouting in endometriosis was performed. Peritoneal lesions (n= 40) and healthy peritoneum (n= 12) were immunostained and analysed with anti-protein gene product 9.5 (PGP 9.5), anti-substance P (SP) and anti-tyrosine hydroxylase (TH), specific markers for intact nerve fibres, sensory nerve fibres and sympathetic nerve fibres, respectively, to identify the ratio of sympathetic and sensory nerve fibres. In addition, immune cell infiltrates in peritoneal endometriotic lesions were analysed and the nerve growth factor (NGF) and interleuki…
Metagenomic, microbiological, chemical and sensory profiling of Caciocavallo Podolico Lucano cheese
2023
In this study, Caciocavallo Podolico Lucano (CPL) cheese was deeply characterized for its bacterial community, chemical composition and sensory aspects. The entire cheese making process (from milk collection to ripened cheese) was performed by strictly applying the traditional protocol for CPL production in four dairy factories (A–D) representative of the production area. The vat made of wood represents the main transformation tool for CPL cheese production and the biofilms hosted onto the internal surfaces of all vats analyzed in this study were dominated by lactic acid bacteria. Total mesophilic microorganisms present in bulk milk (4.7–5.0 log CFU/ml) increased consistently after contact …
Lightweight BWT Construction for Very Large String Collections
2011
A modern DNA sequencing machine can generate a billion or more sequence fragments in a matter of days. The many uses of the BWT in compression and indexing are well known, but the computational demands of creating the BWT of datasets this large have prevented its applications from being widely explored in this context. We address this obstacle by presenting two algorithms capable of computing the BWT of very large string collections. The algorithms are lightweight in that the first needs O(m log m) bits of memory to process m strings and the memory requirements of the second are constant with respect to m. We evaluate our algorithms on collections of up to 1 billion strings and compare thei…
Lightweight algorithms for constructing and inverting the BWT of string collections
2013
Recent progress in the field of \{DNA\} sequencing motivates us to consider the problem of computing the Burrows‚ÄìWheeler transform (BWT) of a collection of strings. A human genome sequencing experiment might yield a billion or more sequences, each 100 characters in length. Such a dataset can now be generated in just a few days on a single sequencing machine. Many algorithms and data structures for compression and indexing of text have the \{BWT\} at their heart, and it would be of great interest to explore their applications to sequence collections such as these. However, computing the \{BWT\} for 100 billion characters or more of data remains a computational challenge. In this work we ad…
Magnetic resonance image segmentation and heart motion tracking with an active mesh based system
2002
International audience; Abstract: The work presented here relates to a method fir motion tracking in sequences of medical images. The purpose is to. quantify the general motions and the local deformations of a beating heart during a cardiac cycle. In order to achieve this goal, we first tessellate the,first image of the sequence into triangular patches. A Delaunay triangulation is applied to find the optimal set of triangles describing this image, giving a mesh covering the organs. One imposes the contours of the organs to correspond to edges of triangles so that each part of the heart (left ventricle, right ventricle, myocardium) can he described as a different set of triai izles, each set…
Acquisition of competencies with serious games in the accounting field: an empirical analysis
2018
El actual sistema de educación superior se basa en un aprendizaje activo por parte del estudiante enfocado al desarrollo de competencias genéricas y específicas. En este contexto muchos autores defienden el uso de simulaciones que favorezcan dicho aprendizaje y, los denominados «juegos serios» (serious games [SG]) se adaptan a este reto. Sin embargo, el empuje que cabría esperar por el desarrollo de las nuevas tecnologías y de la llegada de los denominados «nativos digitales» a las aulas no es coherente ni con su grado de implantación ni con la escasa investigación desarrollada sobre la efectividad de su uso. Los objetivos de este estudio son describir una experiencia docente de implantació…
Differential Effects of Fluvoxamine and Other Antidepressants on the Biotransformation of Melatonin
2001
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19. Both reactions were potently in…
PMG-Pro: A Model-Driven Development Method of Service-Based Applications
2011
Published version of a chapter published in the book: SDL 2011: Integrating System and Software Modeling. Also available from the publisher at: http://dx.doi.org/10.1007/978-3-642-25264-8_12 In the Internet of Things, billions of networked and software-driven devices will be connected to the Internet. They can communicate and cooperate with each other to form a composite system. In this paper, we propose PMG-pro (present, model, generate and provide), a language independent, bottom-up and model-driven method for the development of such composite system. We envision that all devices in the Internet of Things provide their functionalities as services. From a service description, a service pre…