Search results for "Generation"
showing 10 items of 3050 documents
La Sicilia dei centri minori: Above the clouds nella Valle di Bolognetta : architettura, arti performative e nuovi immaginari
2021
Il lavoro elaborato dal Gruppo di ricerca LabCity Architecture sulla rigenerazione dei piccoli centri rurali del territorio siciliano, vittime della crisi economica e demografica di quest’ultimo decennio, evidenzia l’urgenza di un ripensamento delle strategie di intervento in questi luoghi con forti potenzialità territoriali, patrimoniali e culturali, proponendo progetti di ricerca-azione in sinergia con le comunità locali coinvolte. La recente emergenza sanitaria causata dalla pandemia da Covid-19 ha evidenziato l’esigenza di una ricerca mirata ad individuare i caratteri e le esigenze specifiche soprattutto dei centri minori, destinatari di politiche e di interventi spesso inadeguati. In q…
Nonlinear optical properties of diaromatic stilbene, butadiene and thiophene derivatives
2021
Series of highly polar stilbene (1a–e), diphenylbutadiene (2a–c) and phenylethenylthiophene (3a–c) derivatives were prepared via Horner–Wadsworth–Emmons method with a view to produce new and efficient materials for second harmonic generation (SHG) in the solid-state. The single-crystal X-ray structures of compounds 1–3 reveal extensive polymorphism and a peculiar photodimerization of the 2-chloro-3,4-dimethoxy-4′-nitrostilbene derivative 1a to afford two polymorphs of tetra-aryl cyclobutane 4. The stilbene congeners 2-chloro-3,4-dimethoxy-4′-nitrostilbene (1a·non-centro), 5-bromo-2-hydroxy-3-nitro-4′-nitrostilbene (1b) and 4-dimethylamino-4′-nitrostilbene (1e), as well as 4′-fluoro-4′′-nitr…
Augmented Cities in Post-pandemic Age
2020
The effects of the Anthropocene are mainly urban, because the cities with their expansion have devoured the natural soil, the identity structures of the cultural palimpsests and the vegetable plots of the cities, invading delicate natural ecosystems, awakening and expanding diseases previously confined and separated in the wild environments. How to get out of the planetary environmental crisis, which is above all an urban habitats’ crisis? The answer, therefore, can only be urban, acting on a rethinking of cities as places of living in balance with other living species, in homeostasis with the planet. Especially in Europe, we must update the idea of cities as privileged places of public hea…
The Origins of Northern European Autographa Gamma Individuals Evaluated Using Hydrogen Stable Isotopes
2018
1. Many insect species are migratory. As the spring progresses, adults gradually depart from their over‐wintering habitats and arrive in northern zones where they reproduce during the summer. Understanding this transgenerational and highly adaptive migratory behaviour is crucial when interpreting life cycle dynamics of many insect pests. 2. Origins of migratory silver Y moths, Autographa gamma (Linnaeus, 1758), captured from Finland, were studied with stable hydrogen analysis of their wings (δ2Hw). 3. The difference between spring and autumn generation δ2Hw values indicate different geographical natal origins. The probability surface map shows that the spring generation probably emerged in …
Algorithms for the Automated Analysis of Age-Related Macular Degeneration Biomarkers on Optical Coherence Tomography: A Systematic Review
2017
PURPOSE To assess the quality of optical coherence tomography (OCT) grading algorithms for retinal biomarkers of age-related macular degeneration (AMD). METHODS Following a systematic review of the literature data on detection and quantification of AMD retinal biomarkers by available algorithms were extracted and descriptively synthesized. Algorithm quality was assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies 2 checklist with a focus on accuracy against established reference standards and risk of bias. RESULTS Thirty five studies reporting computer-aided diagnosis (CAD) tools for qualitative analysis or algorithms for quantitative analysis were iden…
Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson’s Disease
2021
Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the formation of large aggregates in the survival neurons called Lewy bodies, which mainly contain α-synuclein (α-syn). The cause of cell death is not known but could be due to mitochondrial dysfunction, protein homeostasis failure, and alterations in the secretory/endolysosomal/autophagic pathways. Survival nigral neurons overexpress the small GTPase Rab1. This protein is considered a housekeeping Rab that is necessary to support the secretory pathway, the maintenance of the Golgi complex structure, and the regulation of macroau…
Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo
2019
Dysfunction of autophagy and disturbed protein homeostasis are linked to the pathogenesis of human neurodegenerative diseases and the modulation of autophagy as the protein clearance process has become one key pharmacological target. Due to the role of sigma-1 receptors (Sig-1R) in learning and memory, and the described pleiotropic neuroprotective effects in various experimental paradigms, Sig-1R activation is recognized as one potential approach for prevention and therapy of neurodegeneration and, interestingly, in amyotrophic lateral sclerosis associated with mutated Sig-1R, autophagy is disturbed. Here we analyzed the effects of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hyd…
The Role of Autophagy in Eye Diseases
2021
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellula…
PAESAGGI IN TRASFORMAZIONE: LA RIGENERAZIONE DEL BACINO MINERARIO DEL NORD PAS DE CALAIS L’iscrizione Unesco e la costruzione della strategia generale
2017
L’attività mineraria, al pari di un evento sismico, rappresenta per il territorio una ferita difficile da rimarginare. I luoghi coinvolti assistono al radicale mutamento dei loro paesaggi, alla trasformazione della loro geografia, alla rottura degli equilibri che per secoli avevano sostenuto la loro economia e società. Questa condizione si aggrava ancor di più a seguito della dismissione delle attività, quando il sistema economico della monocoltura mineraria non costituisce più una risorsa e al suolo rimangono i segni di ciò che era stata l’industria estrattiva. I resti fisici dell’attività industriale iniziano, però, dopo alcuni anni, a esercitare un senso di fascinazione sulla stessa soci…
New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spalla…
2021
Abstract The violation of baryon number, B , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation ( n → n ̄ ) via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state ( n → [ n ′ , n ̄ ′ ] → n ̄ ), and neutron disappearan…