Search results for "Generation"

Random quasi-phase-matched second harmonic generation in periodically poled lithium tantalate

2009

We experimentally observed and explained bulk second harmonic generation via random quasi-phase-matching, derived from a periodically poled lithium tantalate sample with a randomly patterned mark-to-space-ratio.

Biosilica

2012

Biomineralization, biosilicification in particular (i.e. the formation of biogenic silica, SiO(2)), has become an exciting source of inspiration for the development of novel bionic approaches following 'nature as model'. Siliceous sponges are unique among silica-forming organisms in their ability to catalyze silica formation using a specific enzyme termed silicatein. In this study, we review the present state of knowledge on silicatein-mediated 'biosilica' formation in marine demosponges, the involvement of further molecules in silica metabolism and their potential applications in nano-biotechnology and bio-medicine. While most forms of multicellular life have developed a calcium-based skel…

ChemInform Abstract: Amphiphilic Dyes for Nonlinear Optics: Dependence of Second Harmonic Generation on Functional Group Substitution.

2010

Covalently linked multi-calixarenes

1998

Abstract ipso-Nitration of t-butyl calix[4]arene tetraethers and subsequent hydrogenation provides an easy access to monoamino calix[4]arenes. Reaction with di- and triacid chlorides leads to various double- and triple-calix[4]arenes. With tetraacid chlorides derived from calix[4]arenes in the cone- or 1,3-alternate-conformations penta-calix[4]arenes are available as molecularly uniform species, which may be regarded as the first generation of calix[4]arene based dendrimers. The structure of the mononitro tetraester derivative, which may serve as a general building block has been confirmed by single crystal X-ray analysis.

A Different Role of Taxation. From a One-Sided Taxation To a Circular Taxation

2020

The essay explores a possible different use of tax revenue, that is a perspective in which taxation is linked to a public choice in a circular way, thus determining a shift from the traditional “one-side taxation” process to a “circular taxation” process. Starting from the widely studied juridical phenomenon, known in Italy as regeneration of common spaces and goods or simply “regeneration”, and addressing the case of the regeneration of a brownfield, the Author argues that this phenomenon shows some common points with the so-called “circular economy”, since they are both inspired by the same principle of making resources usable in a circular context, exploiting already existing goods and r…

A multi-omic liquid biopsy-based signature as a valuable tool to assess minimal residual disease in localised colorectal cancer

2019

El cáncer colorrectal (CCR) es un importante problema de salud pública. Más de 1.2 millones de pacientes se diagnostican de CCR cada año, y más de 600.000 mueren a causa de la enfermedad. El pronóstico de los pacientes con CCR ha mejorado durante las últimas décadas, con una supervivencia a los 5 años que ha alcanzado casi el 65% en países desarrollados. El estadio al diagnóstico es actualmente el factor pronóstico más importante. Aunque la clasificación clásica de estadiaje proporciona información pronóstica y guía las decisiones terapéuticas, no disponemos hoy en día de marcadores predictivos de la respuesta y del resultado clínico de la terapia individual del paciente. Esto es relevante …

Zebrafish Fins as a Model System for Skeletal Human Studies

2007

Recent studies on the morphogenesis of the fins ofDanio rerio(zebrafish) during development and regeneration suggest that a number of inductive signals involved in the process are similar to some of those that affect bone and cartilage differentiation in mammals and humans. Akimenko et al. (2002) has shown that bone morphogenetic protein-2b (BMP2b) is involved in the induction of dermal bone differentiation during fin regeneration. Many other groups have also shown that molecules from the transforming growth factor-beta superfamily (TGFβ), including BMP2, are effective in promoting chondrogenesis and osteogenesisin vivoin higher vertebrates, including humans. In the present study, we review…

Come ascoltare i figli e come farsi ascolatre

2010

In questo breve saggio, sono delineate alcune caratteristiche che la comunicazione reale tra genitori e figli dovrebbe possedere, secondo il personale punto di vista pedagogico dell’autore. A ben vedere, per realizzare questo compito, bisogna prima interpellare i genitori su quello che già sanno sul tema a motivo della loro quotidiana esperienza educativa vissuta a contatto con i loro figli preadolescenti (11-14 anni) e adolescenti (15-19 anni). Per questo, innanzitutto si riferiscono alcune idee sul tema in questione espresse nel contesto dei focus group dai genitori che hanno partecipato agli incontri pedagogici fatti in alcune scuole secondarie di primo e di secondo grado della nostra re…

Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease.

2019

Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin (HTT) gene, translating into an elongated polyglutamine stretch. In addition to the neurotoxic mutant HTT protein, the mutant CAG repeat RNA can exert toxic functions by trapping RNA-binding proteins. While few examples of proteins that aberrantly bind to mutant HTT RNA and execute abnormal function in conjunction with the CAG repeat RNA have been described, an unbiased approach to identify the interactome of mutant HTT RNA is missing. Here, we describe the analysis of proteins that preferentially bind mutant HTT RNA using a mass spectrometry approach. We show that (I) the majority of proteins captured by mutant…

Role of Adenosine Receptors in Rare Neurodegenerative Diseases with Motor Symptoms

2021

: The approval of istradefylline, an adenosine 2A receptor (A2AR) antagonist, as an addon treatment in adult patients with Parkinson’s disease by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), is the latest proof of the importance of the adenosinergic system in the nervous system. Adenosine is an endogenous purine nucleoside with a role as a modulator of both neurotransmission and the inflammatory response. As such, the expression pattern of the 4 adenosine receptors (A1R, A2AR, A2BR and A3R) and the extracellular adenosine levels have attracted great interest in the pathogenesis and possible treatment of rare neurodegenerative diseases with motor symptoms. The…