Search results for "Generation"

Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Ne…

2021

The mitochondrial serine protease HTRA2 has many versatile biological functions ranging from being an important regulator of apoptosis to being an essential component for neuronal cell survival and mitochondrial homeostasis. Loss of HTRA2 protease function is known to cause neurodegeneration, whereas overactivation of its proteolytic function is associated with cell death and inflammation. In accordance with this, our group verified in a recent study that the synthetic peptide ASGYTFTNYGLSWVR, encoding the hypervariable sequence part of an antibody, showed a high affinity for the target protein HTRA2 and triggered neuroprotection in an in vitro organ culture model for glaucoma. To unravel t…

Problématiques de la nutrition en ophtalmologie – application à la dégénérescence maculaire liée à l’âge nutrition in ophthalmology – clinical applic…

2014

« Let food be your medicine. » This contribution from Hippocrates is still timely addressed, especially in the field of ophthalmology. Observational epidemiology reports close associations between food habits and the risk or prevention of several ocular pathologies such as cataract or Age-related Macular Degeneration (AMD). Anti-oxidant vitamins, minerals and lipids are the nutrients that have been the most widely studied. Interventional epidemiology and experimental works partially corroborated these findings. Unexpectedly, the benefit of long chain omega 3 polyunsaturated fatty acids in the prevention of late AMD was not firmly established in Age-Related Eye Disease Study 2 (AREDS2). Neve…

Deep sequencing of the human retinae reveals the expression of odorant receptors

2017

Several studies have demonstrated that the expression of odorant receptors (ORs) occurs in various tissues. These findings have served as a basis for functional studies that demonstrate the potential of ORs as drug targets for a clinical application. To the best of our knowledge, this report describes the first evaluation of the mRNA expression of ORs and the localization of OR proteins in the human retina that set a stage for subsequent functional analyses. RNA-Sequencing datasets of three individual neural retinae were generated using Next-generation sequencing and were compared to previously published but reanalyzed datasets of the peripheral and the macular human retina and to reference…

Serum omega-3 fatty acids are not associated with age-related macular degeneration

2012

Revue non indexée dans le JCR.; International audience; Evaluation of: Kabasawa S, Mori K, Horie-Inoue K et al. Associations of cigarette smoking but. not serum fatty acids with age-related macular degeneration in a Japanese population. Ophthalmology 118(6), 1082–1088 (2011). Age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly. in developed countries. Risk factors for AMD are classified into endogenous nonmodifiable. factors, including genetics and environmental factors such as smoking and dietary habits. Both. epidemiological and experimental studies suggest that dietary omega-3 long-chain fatty acids. would participate to prevent from the develo…

Experimental study of peripheral nerve rigeneration

2011

Prenatalny okres życia człowieka

2020

Rozwój człowieka w prenatalnym okresie życia interesował ludzi już w czasach starożytności. I choć do dziś prowadzi się wiele dyskusji na temat początku ludzkiego życia, należy stwierdzić, że rozwój poczętego dziecka oraz jego kompetencje wskazują na to, że od początku swojego istnienia jest to osoba aktywna i samosterowalna, która czuje, zapamiętuje, uczy się, posiada pewien poziom świadomości. Radzi sobie z trudnościami hamującymi jego rozwój, przystosowuje do zmiennych warunków życia nie tylko wewnątrz-, ale i zewnątrzmacicznego, nabywa pewnych nawyków i przyzwyczajeń, reaguje w indywidualny, charakterystyczny dla siebie sposób

Epilepsy in neuropathologically verified Alzheimer's disease

2018

Purpose Subjects with Alzheimer’s disease (AD) have been shown to be at a higher risk for epilepsy. The vast majority of the previous studies have not included a full neuropathological examination. Methods The objective of this study was to assess the prevalence of epilepsy and clinicopathological characteristics in a well-defined study group of 64 subjects with AD. We evaluated the clinicopathological findings in 64 subjects (mean age at death 85 ± 8.6 years) from a longitudi-nal study cohort of patients with dementia. Results Eleven out of the 64 subjects (17%) had a history of epilepsy, which is comparable to previous studies. The subjects with AD and epilepsy were significantly younger …

Historias del Kronen

2017

International audience

Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety

2020

Functional outcomes of peripheral nerve repair and regeneration: clinical and experimental study

This study investigated pre- and post-operative evaluation of peripheral nerve injuries and functional outcomes of peripheral nerve regeneration after different type of injuries and different type of treatments. Neuromas/scar neuritis and brachial plexus injuries are specifically addressed; literature and experimental evidence on the outcomes of vascularized nerve grafts are presented.