Search results for "Genetic Structures"
showing 10 items of 2107 documents
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.
2013
International audience; Mutations in the myosin VIIa gene cause Usher syndrome type IB (USH1B), characterized by deaf-blindness. A delay of opsin trafficking has been observed in the retinal photoreceptor cells of myosin VIIa-deficient mice. We identified spectrin bV, the mammalian b-heavy spectrin, as a myosin VIIa-and rhodopsin-interacting partner in photoreceptor cells. Spectrin bV displays a polarized distribution from the Golgi apparatus to the base of the outer segment, which, unlike that of other b spectrins, matches the trafficking route of opsin and other phototransduction proteins. Formation of spectrin bV-rhodopsin complex could be detected in the differentiating photoreceptors a…
Navigating the translational roadblock: Towards highly specific and effective all-optical interrogations of neural circuits
2020
AbstractTwo-photon (2-P) all-optical approaches combine in vivo 2-P calcium imaging and 2-P optogenetic modulations and have the potential to build a framework for network-based therapies, e.g. for rebalancing maladaptive activity patterns in preclinical models of neurological disorders. Here, our goal was to tailor these approaches for this purpose: Firstly, we combined in vivo juxtacellular recordings and GCaMP6f-based 2-P calcium imaging in layer II/III of mouse visual cortex to tune our detection algorithm towards a 100 % specific identification of AP-related calcium transients. False-positive-free detection was achieved at a sensitivity of approximately 73 %. To further increase specif…
VAMPIRE: Vessel assessment and measurement platform for images of the REtina
2011
We present VAMPIRE, a software application for efficient, semi-automatic quantification of retinal vessel properties with large collections of fundus camera images. VAMPIRE is also an international collaborative project of four image processing groups and five clinical centres. The system provides automatic detection of retinal landmarks (optic disc, vasculature), and quantifies key parameters used frequently in investigative studies: vessel width, vessel branching coefficients, and tortuosity. The ultimate vision is to make VAMPIRE available as a public tool, to support quantification and analysis of large collections of fundus camera images.
An approach to the measurement of the nonlinear refractive index of very short lengths of optical fibers
2018
A method for the measurement of the nonlinear-refractive index coefficient in single-mode optical fibers is presented. It takes advantage of the high sensitivity of the acousto-optic interaction effect in optical fibers to the fiber properties. Direct measurement of the nonlinear-refractive index change resulting from cross-phase modulation between a probe and a pump signal is obtained from the fiber's acousto-optic interaction performance. It is a non-interferometric method in which a very short length of fiber (<0.25 m) is required.
<title>Study of color centers in optical fibers to be used for ITER plasma diagnostics</title>
2007
ABSTRACT The paper presents a comparative study, by off-line measurements of the irradiation induced optical attenuation in several large diameter (600 µm) optical fibers subjected to gamma-rays and neutron irradiation. The optical fiber samples fall into two categories: optical fibers with an enhanced UV transmission (high OH content core) and solarization resistant optical fibers. The irradiation conditions were as follows: a) gamma irradiation at a 60 Co source, with a dose rate of 0.33 kGy/h +/- 5%, up to the maximum total irradiation dose of 313 kGy; b) neutron irradiation (mean energy 5.2 MeV) using a deuteron beam (13 MeV) and a thick beryllium target, for a total fluence of 6x10 12 …
Observation of Light Confinement Effects with a Near-Field Optical Microscope.
1996
This Letter reports the experimental observation of light confinement effects by near-field optical microscopy. Depolarization effects giving rise to light confinement close to nanoscopic objects have been unambiguously observed in near-field optical images of subwavelength dielectric pads etched on a flat glass substrate. According to the incident polarization, this phenomenon leads to reverse contrasts in the near-field optical image of the same subwavelength objects.
Optical Quality Comparison of Conventional and Hole-Visian Implantable Collamer Lens at Different Degrees of Decentering
2012
To compare the optical quality of implantable Collamer lens (ICL) with and without central hole (Hole ICL and conventional ICL) at different degrees of decentering.Experimental laboratory investigation.Wavefront aberrations of the -3, -6, and -12 diopter (D) V4b and -3, -6, and -12 D V4c ICLs were measured in 3 conditions-centered and decentered 0.3 and 0.6 mm-at 3-mm and 4.5-mm pupils. The root mean square of total higher order aberrations, trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration were evaluated. In addition, point spread function and simulated retinal images of ICLs were calculated from the wavefront aberrations for each ICL and all conditions of decenteri…
Correlation between optics quality of multifocal intraocular lenses and visual acuity
2009
Purpose To study the relationship between the optics quality of multifocal intraocular lenses (IOLs) and distance-corrected near, intermediate, and distance visual acuity to determine the degree to which optics quality must change to produce a significant difference in visual acuity. Setting Fundacion Oftalmologica del Mediterraneo, Valencia, Spain. Methods Monocular distance-corrected visual acuity (decimal and logMAR) was measured at 4 m, 70 cm, and 30 cm under photopic and mesopic conditions in eyes with 1 of 3 multifocal IOL models. Visual acuity versus the “average modulation” of the IOL was assessed. Results The pupil diameter and patient age were similar between the 3 IOL groups (20 …
Can ‘Fellow of the European Board of Ophthalmology Subspecialty Diploma in Glaucoma,’ a subspecialty examination on glaucoma induce the qualification…
2016
From 2015, the examination of Fellow of the European Board of Ophthalmology Subspecialty Diploma in Glaucoma (FEBOS-Glaucoma) was launched by the European Board of Ophthalmology (EBO) in cooperation with the European Glaucoma Society (EGS). This opinion aims at disclosing the background of the examination, prerequisite to the examination, and the value of the FEBOS-Glaucoma diploma.
285 DOWNREGULATION OF ORGANIC CATION TRANSPORTERS OCT1 (SLC22A1) AND OCT3 (SLC22A3) IN HUMAN HEPATOCELLULAR CARCINOMA AND THEIR PROGNOSTIC SIGNIFICAN…
2012
Background Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transporters became pharmaceutically interesting, because OCTs are determinants of the cytotoxicity of platin derivates and the transport activity has been shown to correlate with the sensitivity of tumors towards tyrosine kinase inhibitors. No data exist about the relevance of OCTs in hepatocellular carcinoma (HCC).