Search results for "Genetic algorithm"
showing 10 items of 834 documents
Sizing and shape optimization material use in 10 bar trusses
2021
Truss optimization has the goal of achieving savings in costs and material while maintaining structural characteristics. In this research a 10 bar truss was structurally optimized in Rhino 6 using genetic algorithm optimization method. Results from previous research where sizing optimization was limited to using only three different cross-sections were compared to a sizing and shape optimization model which uses only those three cross-sections. Significant savings in mass have been found when using this approach. An analysis was conducted of the necessary bill of materials for these solutions. This research indicates practical effects which optimization can achieve in truss design.
The Geochemistry of Basalt Handaxes from the Lower Palaeolithic Site of Ma‛ayan Baruch, Israel-A Perspective on Raw Material Selection
2014
The Upper Acheulian site of Ma‛ayan Baruch, northern Israel, is primarily known for its exceptionally large assemblage of thousands of flint handaxes. Within this assemblage, a minute collection of basalt handaxes was retrieved as well, representing particular technological choice within the Upper Acheulian. Using geochemistry, we were able to determine that these basalt handaxes were not made from local basalt, but from different sources. Thus, the use of basalt at the site does not represent an ad hoc choice of using local raw material but, rather, a more complex technological choice pertaining to variability in raw material selection in the Lower Palaeolithic Levant.
Aplicación del Estimador de Parámetros de Segmentación por Media-desplazada (EPSM) a las imágenes de satélite de muy alta resolución espacial: Tetuán…
2015
<p>La segmentación de imágenes constituye un paso crucial en el Análisis de Imágenes Basado en Objetos (AIBO). Combinando distintos valores de los parámetros de entrada de los algoritmos de segmentación se obtienen diferentes resultados. En general, los parámetros óptimos seleccionados se determinan mediante interpretación visual; por lo tanto, la definición de las combinaciones óptimas es una tarea considerablemente difícil. En la presente investigación, se propone una herramienta analítica que denominamos Estimador de Parámetros de Segmentación por Media-desplazada (EPSM) aplicada a la selección automatizada de los valores de los parámetros de segmentación en las imágenes de satélit…
Practical Issues on Energy-Growth Nexus Data and Variable Selection With Bayesian Analysis
2018
Abstract Given that the energy-growth nexus (EGN) is short of a complete theoretical base, the production function used therein is typically complemented with numerous variables that characterize an economy. Researchers are often puzzled not only with the selection of variables per se, but also with the variable sources and the various data handlings which become apparent and available only after years of experience in this research field. Thus, this chapter is divided into two distinctive parts: The first part contains an overview of the available data sources for the EGN as well as a succinct selection of advice on data handlings, transformations, and interpretations that could come handy…
Variable-order reference-free variant discovery with the Burrows-Wheeler Transform
2020
Abstract Background In [Prezza et al., AMB 2019], a new reference-free and alignment-free framework for the detection of SNPs was suggested and tested. The framework, based on the Burrows-Wheeler Transform (BWT), significantly improves sensitivity and precision of previous de Bruijn graphs based tools by overcoming several of their limitations, namely: (i) the need to establish a fixed value, usually small, for the order k, (ii) the loss of important information such as k-mer coverage and adjacency of k-mers within the same read, and (iii) bad performance in repeated regions longer than k bases. The preliminary tool, however, was able to identify only SNPs and it was too slow and memory con…
Influence of ANN parameters on the performance of a refined procedure to solve the load-flow problem
1999
In recent years, interest in the application of Artificial Neural Networks (ANN) to electrical power systems has grown rapidly. In particular the use of ANN in the solution of the load-flow problem in wide electrical networks is an interesting research topic, because it constitutes a good alternative to the classical numerical algorithms. In this paper a refined solution strategy based on statistical methods, on a particular Grouping Genetic Algorithm (GGA) and on Progressive Learning Network (PLN) is presented. Tests on the solution of load-flow equations of the standard IEEE 118 bus network confirm the good potential of this approach; in particular the search for optimal values of the PLN…
Comparative analysis of variation and selection in the HCV genome
2016
AbstractGenotype 1 of the hepatitis C virus (HCV) is the most prevalent of the variants of this virus. Its two main subtypes, HCV-1a and HCV-1b, are associated to differences in epidemic features and risk groups, despite sharing similar features in most biological properties. We have analyzed the impact of positive selection on the evolution of these variants using complete genome coding regions, and compared the levels of genetic variability and the distribution of positively selected sites. We have also compared the distributions of positively selected and conserved sites considering different factors such as RNA secondary structure, the presence of different epitopes (antibody, CD4 and C…
Coordinate mutation and transformation of mouse fibroblasts: induction by nitroquinoline oxide and modulation by caffeine
1981
Mutation and malignant transformation were followed in the same cells. Mouse fibroblasts (C3H 10T 1/2) were mutated and transformed by 4-nitroquinoline-1-oxide with similar, approximately linear dose-responses. The presence of caffeine immediately after exposure to 4-nitroquinoline-1-oxide potently inhibited mutation and transformation at high but not at low doses of 4-nitroquinoline-1-oxide. Whilst the coordinate induction of mutation and transformation could be explained by both a common target (DNA) or a common reactive species hitting several targets, the identical modulation by a DNA repair inhibitor of both end points suggests fundamental similarities in the nature of the lesions lead…
XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma
2020
The XPO1 gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) cases harboured a recurrent XPO1 point mutation (NM_003400, chr2:g61718472C>
Clinical use of RNA sequencing and oncobox analytics to predict personalized targeted therapeutic efficacy.
2020
e13676 Background: Analysis of mutation profiles in cancer patients does not provide clinical benefits in 80-90% of cases in the US (Marquart et al., 2018). Gene expression analysis potentially complements standard detection of clinically relevant mutations. Methods: 239 adult late-stage cancer patients. RNA gene expression sequencing completed on solid tumor samples using FFPE blocks. Patient mRNA profiles were analyzed using Oncobox bioinformatics, prioritizing target drugs according to their personalized predicted efficacy. Summary reports were provided to oncologists and resulting treatment selection and outcomes were assessed. Results: As of February 2020, feedback was received from p…