6533b871fe1ef96bd12d121d
RESEARCH PRODUCT
XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma
Brigitte SolaFrançois GuillonneauVincent Cabaud GibouinAntoine TalyAntoine TalyPierre-julien ViaillyHadjer MiloudiElodie BohersLuca GrumolatoFabrice JardinGaëtan Jegosubject
Cancer ResearchMutantXPO1/CRM1[SDV.CAN]Life Sciences [q-bio]/Cancer[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]CRISPR–Cas9[SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]lcsh:RC254-282Article03 medical and health sciencesXPO10302 clinical medicineproteomics[SDV.CAN] Life Sciences [q-bio]/Cancerimmune system diseasesExportin-1hemic and lymphatic diseases[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]medicine[SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]B-cell lymphomaNuclear export signalproximity ligation assay030304 developmental biology0303 health sciencesimportin β1ChemistryB-cell lymphomaPoint mutationlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseMolecular biologynuclear importindirect immunofluorescenceOncology030220 oncology & carcinogenesisMutation (genetic algorithm)nuclear exportNuclear transportCRISPR-Cas9description
The XPO1 gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) cases harboured a recurrent XPO1 point mutation (NM_003400, chr2:g61718472C>
year | journal | country | edition | language |
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2020-10-01 |