Search results for "Genou"

Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells

2013

AbstractPluripotency is maintained by both known and unknown transcriptional regulatory networks. In the present study, we have identified Zfp819, a KRAB-zinc finger protein, as a novel pluripotency-related factor and characterized its role in pluripotent stem cells. We show that Zfp819 is expressed highly in various types of pluripotent stem cells but not in their differentiated counterparts. We identified the presence of non-canonical nuclear localization signals in particular zinc finger motifs and identified them as responsible for the nuclear localization of Zfp819. Analysis of the Zfp819 promoter region revealed the presence of a transcriptionally active chromatin signature. Moreover,…

Validation transculturelle des critères d'évaluation rapportés par le patient dans l'arthrose des membres inférieurs

2010

In joint diseases, Patient-Reported Outcomes (PROs) are now critical outcome measures, required by health authorities and regulatory agencies. Cross-cultural adaptation and validation of the psychometric properties of such PROs are needed in order to use them in international therapeutic trials. Thanks to this complex process of cross-cultural validation, the PRO in the target language can take into account the specific socio-cultural features and the linguistic equivalences. The aim of this thesis was to undertake the cross-cultural validation of PROs specifically developed for knee and hip disorders. After explaining the published recommendations for cross-cultural adaptation and then con…

The Rise of the Nation-State and Free Transit

2017

With a focus on Anthony Pagden, this section delves into the conquest of Americas, and explains how the manipulation of the concept of hospitality legitimated the subsequent dispossession of aboriginal lands. In part, this was because Spain colonized this continent as Rome did Europe, but, and most important, hospitality played a vital role subordinating the indigenous to European archetype, endorsing and granting legitimacy to Spain’s rule over this New World. In so doing, hospitality not only accompanied the ideological discourse of nationhood, but free transit became the touchstone of the West.

Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats

2007

As an endogenous agonist at the cannabinoid receptor CB1 and the capsaicin-receptor TRPV1, anandamide may exert both anti- and pronociceptive actions. Therefore we studied the effects of anandamide and other activators of both receptors on changes in free cytosolic calcium ([Ca2+]i) in acutely dissociated small dorsal root ganglion neurons (diameter: ≤30 μm). Anandamide (10 μM) increased [Ca2+]iin 76% of the neurons. The EC50was 7.41 μM, the Hill slope was 2.15 ± 0.43 (mean ± SE). This increase was blocked by the competitive TRPV1-antagonist capsazepine (10 μM) and in Ca2+-free extracellular solution. Neither exclusion of voltage-gated sodium channels nor additional blockade of voltage-gate…

Synthesis and Antileukemic Activity of New 3-(5-Methylisoxazol-3-yl) and 3-(Pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones.

2003

3-(3-Methylisoxazol-5-yl) and 3-(pyrimidin-2-yl)-2-styrylquinazolin-4(3H)-ones 8a–l and 9a,c–e,h–l were synthesized by refluxing in acetic acid the corresponding 2-methylquinazolinones 6 and 8 with the opportune benzoic aldehyde for 12 h. The synthesized styrylquinazolinones 8a–l and 9a,c–e,h–l were tested in vitro for their antileukemic activity against L-1210 (murine leukemia), K-562 (human chronic myelogenous leukemia) and HL-60 (human leukemia) cell lines showing in some cases good activity.

The Contribution of the Inter-American Human Rights Bodies to Evolving International Law on Indigenous Rights over Lands and Natural Resources

2010

AbstractBecause of the special relationship with land that characterises indigenous groups, rights over land and natural resources are at the heart of indigenous claims under international law. The Inter-American Commission on Human Rights and the Inter-American Court have developed a copious jurisprudence on the subject matter and contributed to the establishment of certain minimum indigenous peoples' land rights under customary international law. This article analyses the Inter-American judicial discourse on land issues in the light of the current status of relevant international law and reflects upon the potential contribution of the former to the further development of the latter. It fo…

Annual runoff regional frequency analysis in Sicily

2009

Abstract This paper performs annual runoff frequency analysis in Sicily, Italy using the index runoff method. Homogeneous regions, not necessarily defined by geographical boundaries but sharing common features from a morphologic and climatic standpoint, have been identified. For each region a single probability distribution function can be fitted to the available annual runoff data scaled by the index runoff. Starting from an initial dataset of 105 hydrometric stations, 57 stations have been selected using heuristic criteria associated with the Hosking and Wallis’s discordancy measure. The Mantel tests have been then applied to find out the physical and morphological parameters best correla…

STOP 1: Lower Gauja spillway valley at Sigulda

2014

STOP 9: Upper Daugava spillway valley and associated gully network at Vasargelišķi

2014

Archaeometric evidence attesting production of indigenous archaic pottery at Monte Polizzo (Western Sicily)

2012

Excavations at the proto-urban indigenous settlement of Monte Polizzo (western Sicily) have not yielded so far any evidence of in-situ ceramic production (i.e. kiln structures). However several archaeological concerns put forward to consider it as a likely production centre of pottery during the Archaic age. In this paper a first attempt to check the compositional correspondence between ceramic fabrics and local clay sources has been made. A comprehensive archaeometric investigation of native pottery, mainly composed of matte-painted table ware dated from the 7th to the 4th century BC, recovered from the Acropolis of Monte Polizzo has allowed the identification of five distinct ‘Paste Compo…