Search results for "Geriatrics"
showing 10 items of 1388 documents
A New Tool for the Analysis of the Effect of Intracerebrally Injected Anti-Amyloid-β Compounds
2021
Background: A wide range of techniques has been developed over the past decades to characterize amyloid-β (Aβ) pathology in mice. Until now, no method has been established to quantify spatial changes in Aβ plaque deposition due to targeted delivery of substances using ALZET® pumps. Objective: Development of a methodology to quantify the local distribution of Aβ plaques after intracerebral infusion of compounds. Methods: We have developed a toolbox to quantify Aβ plaques in relation to intracerebral injection channels using Zeiss AxioVision® and Microsoft Excel® software. For the proof of concept, intracerebral stereotactic surgery was performed in 50-day-old APP-transgenic mice injected wit…
The Silent Voice of Women Teachers in Latin America. Educating from Invisibility
2020
Resumen Este artículo de investigación presenta el proyecto Mujeres Maestras es un homenaje a las docentes desde la perspectiva de la investigación basada en las artes. Parte de una narrativa personal ambientada en la docencia universitaria como formador de docentes en artes desde hace tres décadas. El proyecto ha evolucionado como acción artística, un work in progress todavía vigente desde 2005. Nuestro objetivo principal consiste en acercarnos a las identidades de las maestras realizando exposiciones en museos, muestras que incorporan tres miradas: las obras del propio autor, los dibujos del alumnado, y los videos de entrevistas a las educadoras. Entre los objetivos secundarios destacamos…
Akzeptanz und Nutzung öffentlicher Automaten durch Ältere: Ergebnisse einer europÄischen Untersuchung
2000
Die Autoren dieses Beitrags stellen Befunde uber altere Manner und Frauen als Nutzer von Fahrkartenautomaten, Bankautomaten und Kartentelefonen vor. Basis der Analysen bilden Daten, die im Rahmen des internationalen Kooperationsprojektes „Keeping the Elderly Mobile“ in vier europaischen Stadten erhoben wurden. Die Untersuchungen fanden 1995 in Mannheim (Westdeutschland) mit 404, in Chemnitz (Ostdeutschland) mit 400, in Ancona (Italien) mit 600 und in Jyvaskyla (Finnland) mit 618 in Privathaushalten lebenden Befragten statt, die aus den jeweiligen Einwohnermeldedregistern zufallig ausgewahlt wurden. Die nach Geschlecht und Alter disproportional geschichtete Stichprobe setzte sich zu gleichen…
Validity and Reliability of a Single Question for Leisure-Time Physical Activity Assessment in Middle-Aged Women.
2020
Purpose: To investigate the validity and test–retest reliability of a single seven-level scale physical activity assessment question (SR-PA L7) and its three-level categorization (SR-PA C3). Methods: The associations of SR-PA L7 and C3 with accelerometer-measured leisure-time physical activity (ACC-LTPA) and with the results of four different physical performance tests (6-min walk [n = 733], knee extension [n = 695], vertical jump [n = 731], and grip force [n = 780]) were investigated among women aged 47–55 years participating in the Estrogenic Regulation of Muscle Apoptosis study (n = 795). The reliability was studied using Spearman correlations with 4-month test–retest period (n = 152). R…
DCTN1 mutation analysis in Italian patients with PSP, MSA, and DLB
2020
Abstract DCTN1 encodes the largest subunit of dynactin complex essential in the retrograde axonal transport and cytoplasmic transport of vesicles; mutations in DCTN1 have been reported predominantly in individuals with Perry syndrome and, recently, in patients with progressive supranuclear palsy. Our genetic screening of DCTN1 in 79 patients with progressive supranuclear palsy, 100 patients with multiple system atrophy, and 28 patients with dementia with Lewy bodies from Italy revealed only synonymous and intronic variants, suggesting that DCTN1 mutations do not have a key role in the development of atypical parkinsonism in the Italian population.
Presence phenomena in parkinsonian disorders: Phenomenology and neuropsychological correlates.
2020
Introduction The feeling of a presence that occurs in the absence of objectively identifiable stimuli is common in parkinsonian disorders. Although previously considered benign and insignificant, recent evidence suggests that presence phenomena may act as the gateway to more severe hallucinations and dementia. Despite this, we still know relatively little about these phenomena. Objective To examine parkinsonian disorder patients' subjective experience of presence phenomena, and retrospectively analyse their cognitive correlates, in order to elucidate the emergence of information processing deficits in parkinsonian disorders. Methods/design 25 patients who endorsed presence phenomena were as…
The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease
2020
© 2020 The Author(s).
Catastrophic health expenditure: A comparative analysis of smoking and non-smoking households in China.
2020
Introduction Smoking is hazardous to health and places a heavy economic burden on individuals and their families. Clearly, smoking in China is prevalent since China is the largest consumer of tobacco in the world. Chinese smoking and nonsmoking households were compared in terms of the incidence and intensity of Catastrophic Health Expenditures (CHEs). The factors associated with catastrophic health expenditures were analyzed. Methods Data for this study were collected from two waves of panel data in 2011 and 2013 from the national China Health and Retirement Longitudinal Study (CHARLS). A total of 8073 households with at least one member aged above 45 were identified each year. Catastrophic…
Malnutrition in elderly: Social and economic determinants
2013
Abstract: Malnutrition occurs frequently in the frailest groups of the population, especially in people who are on a low income and elderly subjects, overall if they are institutionalized. The aim of this study was to assess the prevalence of malnutrition in a sample of elderly people living in different settings and to identify the determinants of malnutrition. Methods: A total of 718 subjects, 472 females (F) and 246 males (M), were recruited from nursing homes or were free living in three different regions in Italy. Nutritional status, depression, social, functional and cognitive status, were evaluated. Results: According to the Mini Nutritional Assessment (MNA), a high prevalence of mal…
Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism.
2003
OBJECTIVES: To examine the association between muscle strength and total and cause-specific mortality and the plausible contributing factors to this association, such as presence of diseases commonly underlying mortality, inflammation, nutritional deficiency, physical inactivity, smoking, and depression. DESIGN: Prospective population-based cohort study with mortality surveillance over 5 years. SETTING: Elderly women residing in the eastern half of Baltimore, Maryland, and part of Baltimore County. PARTICIPANTS: Nine hundred nineteen moderately to severely disabled women aged 65 to 101 who participated in handgrip strength testing at baseline as part of the Women's Health and Aging Study. M…