Search results for "Germany"

Clinical experience of a tricomponent acellular pertussis vaccine combined with diphtheria and tetanus toxoids for primary vaccination in 22,505 infa…

1996

Abstract OBJECTIVES: To assess the safety and tolerability of 12 lots of SmithKline Beecham Biologicals' diphtheria-tetanus-tricomponent acellular pertussis vaccine (DTaP) in a large cohort of 22,000 vaccinees, with detailed analyses of reactivity, immunogenicity, and immune response to pertussis toxin in subsets. METHODS: In a prospective, double-blind, multicenter trial in Germany, 22,505 healthy infants received three vaccinations of DTaP at age 3, 4, and 5 months. Serious adverse events were followed for 1 month after each vaccination, and neurologic events for 1 year or longer. Serum IgG antibodies were assayed before vaccination and 1 month after vaccination. RESULTS: After 67,000 dos…

Effectiveness of hexavalent vaccines against invasive Haemophilus influenzae type b disease: Germany's experience after 5 years of licensure

2007

Summary Vaccine effectiveness (VE) was determined with a case-cohort approach using Cox regression. Cases with confirmed systemic Hib infections in children born from 1 August 2000 to 31 December 2004 were ascertained through two independent nationwide active surveillance systems. A representative cohort of 1303 children born in the same time frame was randomly sampled in a nationwide immunisation survey. Thirty cases were eligible for VE calculation; 19 were unvaccinated and 11 vaccinated with hexavalent vaccines. VE was 68.4% (95% CI: 19.0–87.6) for incomplete primary series and 90.4% (95% CI: 70.6–96.8) for the full primary series. For full immunisation VE was 100.0% (95% CI: 52.7–100.0)…

Wilms tumours diagnosed by routine physical examinations.

1988

Sir: The prognosis of stage I and -II Wilms tumours with favourable histology is good, reaching 97% (stage I) and 92% (stage II) 5 year disease-free survival rates [1]. With these figures in mind the question arises whether the overall prognosis of Wilms tumours could be improved by presymptomatic routine physical examinations in an attempt to avoid stage III to V primary diagnoses. In the Federal Republic of Germany six routine physical examinations (RPE) are offered to infants, and two additional ones to children between 12 and 48 months. The 1980-1987 German Wilms tumour study [1] listed 313 patients, 29 of whom (9%) were diagnosed by such routine examinations. As shown in Table 1, the R…

Problems of the Continental Permian in the Federal Republic of Germany

1976

The occurrences of Continental Permian in the Federal Republic of Germany are generally well understood but some problems remain. These are outlined and discussed in the present paper.

Extemporaneous formulations in Germany – relevance for everyday clinical practice

2017

Background Extemporaneous formulations broaden the spectrum of therapeutic options for topical treatment in particular and thus improve patient care. The latest amendment to the Regulation on the Operation of Pharmacies issued in 2012 brought about changes in prescribing and manufacturing practices. The aim of the present study was to assess the relevance of extemporaneous formulations in everyday clinical practice. Methods We used data from the German Institute for Drug Use Evaluation (DAPI) to analyze the prescribing practice for compounded preparations in Germany between the fourth quarter of 2011 and the third quarter of 2014. In doing so, we determined the total cost associated with ex…

The Influence of Dorpat on the Emergence of Pharmacology as a Distinct Discipline

1968

Award ceremony of the E.K. Frey-E. Werle Foundation of the Henning L. Voigt family.

1997

Antiepileptic drug use in nursing home residents: a cross-sectional, regional study.

2006

Summary The use of antiepileptic drugs (AED), their primary indication, comorbid conditions, and concomitant medications were collected from 565 nursing homes (NH) residents of six NH located around the city of Mainz, Germany representing 5.05% of all NH residents in the area. Data were collected from the electronic pharmacy files and by reviewing all available medical records. Average age was 82.2±2.4 years, 85.5% were women. Of 565 NH residents 28 (4.96%) received AED therapy, of which in 17 (63%) AED were prescribed for a seizure-related diagnosis. In 76.5% seizure types were unspecified and a distinction in focal and generalized epilepsy was made in only 23.5% of patients. Three patient…

The Baltic Historians of Pedagogy and the International Standing Conference for the History of Education

2014

ISCHE, which is the leading organization in the field of history of education in the world, was founded in 1979 in Leuven, Belgium. The initiators to establish the organization were scholars mainly from Belgium, the Federal Republic of Germany and the UK. The “socialist block” in this first meeting was represented by Poles and Hungarians. In the later years, the conference was organized annually in a different country sometimes gathering tens and even hundreds of participants (Luth, n.d.). The first president of ISCHE was a fascinating personality, British lord and communist, one of the most outstanding historians of education in the 20th century Brian Simon (1915–2002) (see McCulloch, 2011…

Irradiation facility at the TRIGA Mainz for treatment of liver metastases

2009

Abstract The TRIGA Mark II reactor at the University of Mainz provides ideal conditions for duplicating BNCT treatment as performed in Pavia, Italy, in 2001 and 2003 [Pinelli, T., Zonta, A., Altieri, S., Barni, S., Braghieri, A., Pedroni, P., Bruschi, P., Chiari, P., Ferrari, C., Fossati, F., Nano, R., Ngnitejeu Tata, S., Prati, U., Ricevuti, G., Roveda, L., Zonta, C., 2002. TAOrMINA: from the first idea to the application to the human liver. In: Sauerwein et al. (Eds.), Research and Development in Neutron Capture Therapy. Proceedings of the 10th International Congress on Neutron Capture Therapy, Monduzzi editore, Bologna, pp. 1065–1072]. In order to determine the optimal parameters for the…