Search results for "GiST"

showing 10 items of 3463 documents

Cross-sectional associations between the diversity of sport activities and the type of low back pain in adulthood

2020

Leisure-time physical activity has a complex relationship with low back pain (LBP). Thus, we aimed to investigate whether the diversity of sport activities is associated with the type of LBP. In the FinnTwin16 study, 4246 (55% females) Finnish twins at mean age 34.1 years replied to a health behaviour survey in 2010-2012. Based on the participation in different sport activities, we created two measures of diversity: quantity (i.e. the number of sport activities: 1, 2, 3, 4 and >= 5) and quality (i.e. the type of sport activity: endurance, strength, body care, etc.). Based on the frequency, duration and type of LBP, we created three groups: no history of LBP lasting more than one day, radiat…

Malephysical activitylumbagoliikuntaLogistic regressionRunning0302 clinical medicineOdds RatioOrthopedics and Sports Medicinekohorttitutkimuslow back painexerciseConfoundingGeneral MedicineLow back pain3142 Public health care science environmental and occupational healthPREVALENCEpopulation characteristicsselkäFemalemedicine.symptomCohort studyfyysinen aktiivisuusSportsCohort studyAdultmedicine.medical_specialtyPhysical activity030209 endocrinology & metabolismPhysical Therapy Sports Therapy and Rehabilitationiskias03 medical and health sciencesSex FactorsDiseases in Twinsmedicinecohort studyHumanssciaticabusiness.industryDISABILITYHealth behaviourkipu030229 sport sciencesOdds ratioBicyclingnervous system diseasesLogistic ModelsPHYSICAL-ACTIVITYPhysical EndurancePhysical therapybusinesshuman activitiesDiversity (business)
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Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: results from the Italian Psocare registry

2014

Background: Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective: We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods: Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results: In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis …

Maleprimary inefficacy75% improvement in the Psoriasis Area Severity Index score; PASI; PASI 75; Psoriasis Area Severity Index; TNF; biologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor; tumor necrosis factor-alfa inhibitors; Adult; Analysis of Variance; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Cohort Studies; Confidence Intervals; Dose-Response Relationship Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunoglobulin G; Italy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Psoriasis; Receptors Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young AdultSWITHCESefficacyTNFpsoriasis; psoriasis arthritis; pharmachological treatmentPASI 75Severity of Illness IndexReceptors Tumor Necrosis FactorEtanerceptCohort StudiesMonoclonalReceptorsSettore MED/35 - Malattie Cutanee E VenereeRegistriesHumanizedtumor necrosis factor-alfa inhibitors.switchingHazard ratioAntibodies MonoclonalMiddle AgedTreatment OutcomeItalyPredictive value of tests75% improvement in the Psoriasis Area Severity Index scoreFemaleDrugPsoriasis Area Severity IndexbiologicTNF-alphaAdultmedicine.medical_specialtytumor necrosis factorDermatology75% improvement in the Psoriasis Area Severity Index score; PASI; PASI 75; Psoriasis Area Severity Index; TNF; biologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor; tumor necrosis factor-alfa inhibitorsAntibodies Monoclonal Humanizedsecondary loss of efficacyRisk AssessmentAntibodiestumor necrosis factor-alfa inhibitorsDrug Administration ScheduleDose-Response RelationshipYoung AdultSettore MED/35Predictive Value of TestsInternal medicinePsoriasisSeverity of illnessmedicineConfidence IntervalsHumansPsoriasisbiologicsAdverse effectPsoriasis; TNF-alphaProportional Hazards ModelsRetrospective Studiespsoriasibiologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor-alfa inhibitors; Adalimumab; Adult; Analysis of Variance; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Cohort Studies; Confidence Intervals; Dose-Response Relationship Drug; Drug Administration Schedule; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Infliximab; Italy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Psoriasis; Receptors Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult; 2708Analysis of Variancepharmachological treatmentDose-Response Relationship DrugProportional hazards modelbusiness.industrytumor necrosis factor-alfa inhibitorTumor Necrosis Factor-alphaPASIAdalimumabRetrospective cohort studypsoriasis arthritismedicine.diseaseConfidence intervalInfliximabSurgeryImmunoglobulin GMultivariate AnalysisANTI-TNFAbusiness2708Follow-Up Studies
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Drug‐refractory myasthenia gravis: Clinical characteristics, treatments, and outcome

2022

[Objective] To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.

Maleprogressive multifocal leukoencepdiarrheacholinergic receptorplasma exchangemiddle agedadultimmunologic factornauseaanemiahypertrichosisageddrug withdrawaldiabetes mellitusdisease severityTRIALsafetycorticosteroidhypertensionImmunologyMiastenia gravismethotrexateArticlebulbar paralysispancytopeniaMuscular DiseasescompulsionMyasthenia Gravischolinesterase inhibitorcross-sectional studyHumansImmunologic FactorshumanRITUXIMABarthralgiaNeurologíaMalalties muscularsAgedRetrospective Studiesmyasthenia gravisleukopeniaabdominal painDrug testingmajor clinical studyCross-Sectional StudiesDrug side effectscyclophosphamideobservational studyNeurology (clinical)immunoglobulinFEATURESefficacyclinical outcomeelectrophysiological procedurescomputer assisted tomographyDOUBLE-BLINDTratamiento médicorituximabOutcome Assessment Health CareImmunologiamuscle specific tyrosine kinaseRegistriestacrolimusazathioprineMedicamentoGeneral Neurosciencenephrotoxicitygeneral condition deteriorationhyperplasiatrialMiddle Agedliver toxicitydrug toxicityunclassified drugfemaleEfectes secundaris dels medicamentsSAFETYFemaledouble-blindheadacheblindnessAdultAssaigs clínics de medicamentsmalefeaturesfollow uppneumoniacyclosporinemycophenolate mofetilprotein tyrosine kinaseimmunosuppressive agentallergyalopeciaEFFICACYclinical featureosteopeniaSpainprednisonehyperglycemiaautoantibodyFollow-Up Studies
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Toward Prevention of Doping in Youth Sport: Cross-Sectional Analysis of Correlates of Doping Tendency in Swimming.

2019

Doping is recognized as one of the most important problems in sports, but a limited number of studies have investigated doping problems in youth athletes. This study aimed to evaluate doping tendency (potential doping behavior (PDB)) and correlates of PDB in youth age swimmers. The participants were 241 competitive swimmers (131 females

MalepubertyknowledgeYounger ageAdolescentCross-sectional studyHealth Toxicology and MutagenesisSloveniainformation scienceSports nutritionCoachingArticle03 medical and health sciences0302 clinical medicineRisk FactorsAchievement Knowledge Performance enhancement PubertyHumansnatural sciences030212 general & internal medicineRisk factorSwimmingMultinomial logistic regressionDoping in SportsSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' SportiveDescriptive statisticsbiologyAthletesbusiness.industryYouth SportsachievementPublic Health Environmental and Occupational Health030229 sport sciencesbiology.organism_classificationperformance enhancementCross-Sectional StudiesAdolescent BehaviorAthletesFemalePsychologybusinesshuman activitiesachievement ; knowledge ; performance enhancement ; pubertyDemography
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Exploring the Association between Alcohol Drinking and Physical Activity in Adolescence; Two-Year Prospective Study in Younger Adolescents from Bosni…

2021

Insufficient physical activity and alcohol consumption (AC) are important health-threatening behaviors in adolescence, but there are controversial findings regarding the association that may exist between AC and physical activity levels (PALs) at this age. This study aimed to prospectively examine the relationship that may exist between AC and PAL in younger adolescence, considering the potential confounding effect of sports participation. The participants (n = 669, 337 females) were adolescents from Bosnia and Herzegovina who were tested on two occasions, at baseline (14 years of age) and again at follow-up (16 years of age). The variables included AC (as indicated by the AUDIT questionnai…

Malepubertymedicine.medical_specialtyAdolescentAlcohol DrinkingHealth Toxicology and Mutagenesisphysical activity; puberty; AUDIT; alcohol; substance misuse; sportPhysical activityphysical activityAuditArticlemedicineHumansProspective StudiesAssociation (psychology)Prospective cohort studyExerciseMultinomial logistic regressionBosnia and HerzegovinabiologyalcoholAthletesbusiness.industryPublic healthsubstance misuseRPublic Health Environmental and Occupational Healthphysical activity ; puberty ; AUDIT ; alcohol ; substance misuse ; sportbiology.organism_classificationConfounding effecthumanitiesMedicineFemaleAUDITsportbusinessSportsDemographyInternational Journal of Environmental Research and Public Health
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Use of antidepressants among Finnish family caregivers : a nationwide register-based study

2021

Abstract Purpose The purpose of this study was to compare the use of antidepressants over 6 years between family caregivers providing high-intensity care and a matched control population using register-based data. Methods The study includes all individuals, who received family caregiver’s allowance in Finland in 2012 (n = 29,846 females, mean age 66 years; n = 12,410 males, mean age 71 years) and a control population matched for age, sex, and municipality of residence (n = 59,141 females; n = 24,477 males). Information on purchases of antidepressants, including the number of defined daily doses (DDD) purchased, between 2012 and 2017 was obtained from the national drugs reimbursement registe…

Maleregisters.Health (social science)Epidemiology3124 Neurology and psychiatry0302 clinical medicinemielenterveysomaishoitajatEpidemiologyMedicine030212 general & internal medicineperhehoitoReimbursementFinlandperhehoitajatinformal caregivingeducation.field_of_studyFamily caregiversRegistersAntidepressantsAntidepressive Agents3142 Public health care science environmental and occupational health3. Good healthPsychiatry and Mental healthCaregiversInformal caregivingantidepressantsFemaleMental healthmental healthmasennusmedicine.medical_specialtySocial PsychologyPopulation03 medical and health sciencesHumanseducationSocioeconomic statusAgedOriginal Paperbusiness.industryMental healthConfidence intervalAgeinglääkkeetikääntyminenSocial ClassageingRelative risklääkehoitobusiness030217 neurology & neurosurgeryhoitotyöDemography
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Long-term anti-TNF therapy and the risk of serious infections in a cohort of patients with rheumatoid arthritis: Comparison of adalimumab, etanercept…

2012

Objective: To evaluate the risk of serious infections (SIs) in RA patients receiving anti-TNF therapy on the basis of the data included in the GISEA register. METHODS: The study involved 2769 adult patients with long-standing RA (mean age 53.2±13.4years; mean disease duration 9.0±8.3years) enrolled in the GISEA register, who had been treated for at least 6months with TNF inhibitors or had discontinued therapy due to SI: 837 (30%) treated with infliximab (IFN), 802 (29%) with adalimumab (ADA), and 1130 (41%) with etanercept (ETN). RESULTS: 176 patients had experienced at least one of the 226 Sis during the 9years of treatment with an anti-TNF agent, an overall incidence of 31.8/1000 patient-…

Malerheumatoid arthritisArthritisReceptors Tumor Necrosis FactorEtanerceptEtanerceptArthritis RheumatoidAdalimumab; Adult; Aged; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Antirheumatic Agents; Arthritis Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Incidence; Infection; Infliximab; Male; Middle Aged; Receptors Tumor Necrosis Factor; Registries; Tumor Necrosis FactorsRheumatoidadalimumabMonoclonalReceptorsImmunology and AllergyRegistriesinfectionsHumanizedAnti-TNF agents; GISEA register; Infections; Predictive factorsIncidence (epidemiology)IncidenceAntibodies MonoclonalAnti-TNF agentsMiddle AgedRheumatoid arthritisAntirheumatic AgentsCohortTumor Necrosis FactorsFemaleInfectionPredictive factorsmedicine.druganti-TNF; serious infections; rheumatoid arthritisAdultmedicine.medical_specialtyanti-TNF therapy; infections; rheumatoid arthritis; adalimumab; etanercept; infliximabanti-TNF therapyserious infectionsImmunologyInfections rheumatoid arthritis anti-TNF therapyAntibodies Monoclonal HumanizedInfectionsAntibodiesInternal medicinemedicineAdalimumabHumansAgedGISEA registerbusiness.industryArthritisAdalimumabanti-TNFGISEA register; Infections; Anti-TNF agents; Predictive factors; Adalimumab; Adult; Aged; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Antirheumatic Agents; Arthritis Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Incidence; Infection; Infliximab; Male; Middle Aged; Receptors Tumor Necrosis Factor; Registries; Tumor Necrosis Factorsmedicine.diseaseInfliximabInfliximabConcomitantImmunoglobulin GImmunologyTumor Necrosis Factor InhibitorsbusinessTumor Necrosis Factorinfliximabetanercept
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School Satisfaction and School Pressure in the WHO European Region and North America: An Analysis of Time Trends (2002–2018) and Patterns of Co-occur…

2020

Purpose: The purpose of the study was to examine the trends between 2002 and 2018 in school pressure and school satisfaction among 15-year-old students, across countries and by gender, in the WHO European region and North America, and explore whether there are variations between countries and by gender in the co-occurrence of school pressure and school satisfaction. Methods: Data from the 32 countries that participated in the Health Behaviour in School-aged Children study (HBSC) study between 2002 and 2018 were used. Statistical analyses included ttests, binary logistic regression analyses, and chi-square tests, as required by each of the study aims. Results: School satisfaction tended to i…

Maleschool satisfactionyläkoululaisetPohjois-AmerikkaPersonal SatisfactionLogistic regressionhenkinen hyvinvointi0302 clinical medicinenuoretStatistical analyses030212 general & internal medicineEurooppaChildkoulunkäyntiSchoolsEuropean regionEuropePsychiatry and Mental health15-year-old studentsFemaleyläkouluPsychologytrendsmedicine.medical_specialtyAdolescenteducationWorld Health Organization03 medical and health sciencesSex Factorsvertaileva tutkimus030225 pediatricsco-occurrencemedicineHumansStudentsschool pressureTime trendsPublic healthPublic Health Environmental and Occupational HealthCo-occurrenceHealth behaviourstressitrenditAdolescent BehaviortyytyväisyysNorth AmericaPediatrics Perinatology and Child HealthQuality of LifeadolescenceStress PsychologicalDemographyJournal of Adolescent Health
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Long-term outcomes in men and women with ST-segment elevation myocardial infarction and incomplete reperfusion after a primary percutaneous coronary …

2019

Background The failure of reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) is more frequent than considered previously. Aim To evaluate sex-related differences in long-term outcomes in patients with STEMI and incomplete infarct-related artery reperfusion after a primary percutaneous coronary intervention. Patients and methods Of consecutive 42 752 patients with STEMI hospitalized between 2009 and 2011 in Poland, we analyzed a group of 766 (35%) women and 1453 (65%) men with less than thrombolysis in myocardial infarction (TIMI) flow grade 3 following a primary percutaneous coronary intervention. Results In the 2-year follow-up, the mortality rate among…

Malesex differencesTime Factorsmedicine.medical_treatmentCoronary Artery Disease030204 cardiovascular system & hematology0302 clinical medicineRisk FactorsPrevalenceRegistriesTreatment Failure030212 general & internal medicineMyocardial infarctionStrokeAged 80 and overIncidenceMortality rateHazard ratioGeneral MedicineMiddle Agedprimary percutaneous coronary interventionCardiologyFemaleCardiology and Cardiovascular Medicinelong-term outcomesTIMImedicine.medical_specialtyPatient ReadmissionRisk Assessment03 medical and health sciencesPercutaneous Coronary InterventionSex FactorsReperfusion therapyCoronary CirculationInternal medicinemedicineHumanscardiovascular diseasesAgedHeart Failurebusiness.industryPercutaneous coronary interventionHealth Status Disparitiesmedicine.diseaseST-segment elevation myocardial infarctionincomplete reperfusionHeart failureST Elevation Myocardial InfarctionPolandbusinessCoronary Artery Disease
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Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PRE…

2019

Background: This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods: This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m(2)) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had >= 3…

MalesueñoTime FactorshumanosMedicine (miscellaneous)ejercicio físicoType 2 diabetes030204 cardiovascular system & hematologyLogistic regressiontriglicéridosIsotemporal substitutionchemistry.chemical_compound0302 clinical medicineRisk FactorsAccelerometryInactive timeModerate-to-vigorous physical activityModerate to vigorous physical activityTime in bedlcsh:RC620-627mediana edadAdiposityCardiometabolic risk Inactive time Isotemporal substitution Light physical activity Moderate to vigorous physical activity Time in bedMetabolic SyndromeancianoNutrition and Dieteticslcsh:Public aspects of medicinecolesterolMiddle AgedLight physical activity3. Good healthlcsh:Nutritional diseases. Deficiency diseasesCholesterolCardiovascular diseasesFemaleadiposidadWaist Circumferencemedicine.medical_specialtyWaistRestPhysical Therapy Sports Therapy and RehabilitationClinical nutrition03 medical and health sciencesfactores de tiempo:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Internal medicineacelerometríaDiabetes Mellitusmedicinefactores de riesgoHumansObesityobesidadExerciseTriglyceridesAgedRetrospective Studiesperímetro abdominalMalalties cardiovascularsbusiness.industryResearchestudios retrospectivosCholesterol HDLlcsh:RA1-1270030229 sport sciencesPhysical fitnessmedicine.diseaseObesityUnited KingdomCardiometabolic riskCross-Sectional StudiesBlood pressureDiabetes Mellitus Type 2chemistryDescansGlycated hemoglobinSedentary BehaviorMetabolic syndromeSleepbusinessestudios transversalesCondició físicaInternational Journal of Behavioral Nutrition and Physical Activity
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