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RESEARCH PRODUCT
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study
Lidia DaimielJordi Salas-salvadóFrancisco J. TinahonesFrancisco J. TinahonesOlga PortolésOlga PortolésBlanca Riquelme GallegoBlanca Riquelme-gallegoPilar Matía-martínLaura M Compañ GabucioHelmut SchröderÁNgel M. Alonso-gómezÁNgel M. Alonso-gómezJosep VidalJosep VidalClotilde VázquezJ. Alfredo MartínezJ. Alfredo MartínezJ. Alfredo MartínezF. Javier Barón LópezEmilio RosEmilio RosJuan Carlos Benavente MarínJosé Carlos Fernández-garcíaJosé Carlos Fernández-garcíaRamon EstruchRamon EstruchMiguel FiolXavier PintóXavier PintóAna García-arellanoAna García-arellanoJadwiga KoniecznaJosé LapetraJosep A. TurJosep A. TurMontserrat FitóAndrés Díaz-lópezLaura TomainoLaura TomainoLaura TomainoOlga CastañerEva M. AsensioEva M. AsensioMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezAina M. Galmes-panadesJosé Manuel Santos-lozanoItziar AbeteItziar AbeteLuis Alfredo Mira-castejónDora RomagueraCristina RazquinCristina RazquinAntonio Garcia-riosAntonio Garcia-riosKarla Alejandra Pérez-vegaDolores CorellaDolores CorellaNerea Becerra-tomásFrancisca FiolJesús VioqueMiguel Ruiz-canelaMiguel Ruiz-canelaLuis Serra-majemLuis Serra-majemVeronica Varela-matoAna GaleraAnai Moreno RodríguezAnai Moreno RodríguezCatalina M. MascaróCatalina M. MascaróJessica Vaquero-lunaJessica Vaquero-lunaRosa CasasRosa CasasJosé J. GaforioJosé J. GaforioChristopher PapandreouJulia WärnbergJulia WärnbergRafael Manuel Micó Pérezsubject
MalesueñoTime FactorshumanosMedicine (miscellaneous)ejercicio físicoType 2 diabetes030204 cardiovascular system & hematologyLogistic regressiontriglicéridosIsotemporal substitutionchemistry.chemical_compound0302 clinical medicineRisk FactorsAccelerometryInactive timeModerate-to-vigorous physical activityModerate to vigorous physical activityTime in bedlcsh:RC620-627mediana edadAdiposityCardiometabolic risk Inactive time Isotemporal substitution Light physical activity Moderate to vigorous physical activity Time in bedMetabolic SyndromeancianoNutrition and Dieteticslcsh:Public aspects of medicinecolesterolMiddle AgedLight physical activity3. Good healthlcsh:Nutritional diseases. Deficiency diseasesCholesterolCardiovascular diseasesFemaleadiposidadWaist Circumferencemedicine.medical_specialtyWaistRestPhysical Therapy Sports Therapy and RehabilitationClinical nutrition03 medical and health sciencesfactores de tiempo:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Internal medicineacelerometríaDiabetes Mellitusmedicinefactores de riesgoHumansObesityobesidadExerciseTriglyceridesAgedRetrospective Studiesperímetro abdominalMalalties cardiovascularsbusiness.industryResearchestudios retrospectivosCholesterol HDLlcsh:RA1-1270030229 sport sciencesPhysical fitnessmedicine.diseaseObesityUnited KingdomCardiometabolic riskCross-Sectional StudiesBlood pressureDiabetes Mellitus Type 2chemistryDescansGlycated hemoglobinSedentary BehaviorMetabolic syndromeSleepbusinessestudios transversalesCondició físicadescription
Background: This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods: This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m(2)) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had >= 3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results: Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions: Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-23 | International Journal of Behavioral Nutrition and Physical Activity |