Search results for "Glaucoma."
showing 10 items of 313 documents
Visual Field defects, type A personality,anxiety and coping style in patients with primary open angle glaucoma.
2012
Classification of glaucomatous visual field defects for different severity levels is important. The reasons for this are numerous, and include: to distinguish between healthy and diseased individuals, to have homogeneous grouping criteria when perimetry is used to define the severity of glaucoma, to adjust therapy on the basis of disease severity, to describe visual field conditions in a short and simple format, to monitor the progression of the disease, and to provide a common language for both clinical and research purposes. Many severity classification methods have been proposed, although none have had widespread use in clinical practice. Other methods, like the cumulative defect curve (…
Plasmalogens in the pathogenesis of glaucomatous optic neuropathy
2011
Neuronal tissues such as the retina contain high amounts of plasmalogens. One of their particularities is to concentrate polyunsaturated fatty acids (PUFA) before releasing them specifically. Several data from our laboratory suggest that plasmalogens are involved in the pathophysiology of primary open angle glaucoma (POAG), the second leading cause of blindness worldwide. The different experiments were carried out on human patients with POAG as well as on rodent models of glaucoma. They concerned either the identification of specific alterations of plasmalogen metabolism, or the efficacy of PUFAs to prevent retinal damage. The results have shown a loss of several circulating plasmalogens in…
Cholesterol metabolism via cyp46a1 in glaucoma
2012
Cholesterol metabolism via cyp46a1 in glaucoma. International society for eye research (ISER) annual meeting
Characterization of cholesterol metabolism in an experimental model of glaucoma in rats
2019
International audience; Glaucoma is a neurodegenerative pathology characterized by retinal ganglion cell death. Cholesterol homeostasis disruption has been implicated in several neurodegenerative diseases such as Alzheimer and Huntington. However, its specific role in the retina and association with glaucoma remain unclear. The aim of this study was to characterize the modifications of cholesterol metabolism occurring during an experimental model of glaucoma in rats. Eight-weeks old male rats were subjected to laser photocoagulation of episcleral veins, limbus and trabecular meshwork to elevate intraocular pressure. At a short (3 days) and a long (2 months) time period post-laser, the retin…
Patient/physician "Bond" in the management of glaucoma
2011
Patient/physician "Bond" in the management of glaucoma. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Cholestérol-24S-hydroxylase (CYP46A1) et homéostasie du cholestérol dans la rétine en conditions physiologiques et pathologiques
2012
Cholesterol is the major sterol found in the retina. In its free form, cholesterol is present in all cell layers of the retina, whereas cholesteryl esters mainly accumulate at the basement of the retinal pigment epithelium. The intrinsic capacity of the retina to synthetize cholesterol appears limited. Some extra-retinal pathways actively participate to cholesterol uptake to the retina. Müller glial cells may contribute to cholesterol supply to retinal neurons, especially for synaptic formation. Cholesterol accumulation or conversely deficiency have deleterious consequences on neuron survival. Maintaining the equilibrium between cholesterol supply and neosynthesis in the one hand and choles…
Temari de Farmacologia Ocular per al Grau d'Òptica i Optometria (part teòrica, 12 temes; curs 2019-2020)
2019
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. Tema 1. Principis generals De Farmacologia 1.1. Assajos clínics, Farmacovigilància, normativa legal de la utilització dels fàrmacs per L’òptic-optometrista 1.2. Farmacocinètica 1.3. Vies d’administració dels fàrmacs. Administració dels fàrmacs en l’ull 1.4. Mecanisme d’acció dels fàrmacs Tema 2. Fàrmacs midriàtics i miòtics Tema 3. Fàrmacs antiglaucomatosos Tema 4. Fàrmacs antibiòtics i antivirals Tema 5. Fàrmacs antiinflamatoris, analgèsics i antial·lèrgics Tema 6. Fàrmacs lubricants de la superfície ocular Tema 7. Anestèsics locals Tema 8. Fàrmacs ut…
Glaucoma and Antioxidants: Review and Update
2020
Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to assemble the studies published in relation to antioxidant supplementation and its effects on glaucoma and to offer the reader an update on this field. With this purpose, we have included studies in animal models of glaucoma and clinical trials. Although there are variable results, supplementation with antioxidants in glaucoma may be a promising therapy in glaucoma.
The Role of Autophagy in Eye Diseases
2021
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellula…
Does autoimmunity play a part in the pathogenesis of glaucoma?
2013
Glaucoma is a chronic neurodegenerative disease and one of the leading causes of blindness. Several risk factors have been described, e.g. an elevated intraocular pressure (IOP), oxidative stress or mitochondrial dysfunction. Additionally, alterations in serum antibody profiles of glaucoma patients, upregulation (e.g. anti-HSP60, anti-MBP) and downregulation (e.g. anti-14-3-3), have been described, but it still remains elusive if the autoantibodies seen in glaucoma are an epiphenomenon or causative. However, it is known that elicited autoimmunity causes retinal ganglion cell loss resulting in glaucomatous-like damage and according to the autoaggressive nature of some autoantibodies we found…