Search results for "Glucuronates"

showing 2 items of 12 documents

Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7

1999

Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Among the glucuronidation reactions of PAH metabolites studied, mono- and diglucuronide formation of benzo[a]pyrene and chrysene-3,6-diphenol showed the highest induction factors in rat liver microsomes. Availability of AHH-1 cells stably expressing UGT1A7 allowed us to study whether this PAH-inducible isoform could catalyze benzo[a]pyrene and chrysene-3,6-diphenol glucuronidation. It was found that UGT1A7 indeed catalyzed mono- and diglucuronide formation of both benzo[a]pyrene and chrysene 3,6-diphenols. V79 cell-expressed rat UGT1A6 also catalyzed these re…

PharmacologyChrysenechemistry.chemical_classificationStereochemistryMetaboliteGlucuronidationPolycyclic aromatic hydrocarbonGlucuronatesTransfectionBiochemistryChrysenesCell LineSubstrate SpecificityKineticschemistry.chemical_compoundPhenolschemistryBenzo(a)pyreneBenzo(a)pyrenepolycyclic compoundsPyrenePhenolsGlucuronosyltransferaseHymecromoneCarcinogenBiochemical Pharmacology
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Hydroxylation and conjugation of phenol by the frog Rana temporaria.

1985

1. Frogs injected with phenol excrete 67–95% of dose in 15h; 32–87% of dose are metabolites.2. Metabolites identified were phenyl sulphate (15–44% of dose), phenyl glucuronide (10–25% of dose), catechol sulphate (up to 7% of dose), quinol sulphate (1–25% of dose), resorcinol and catechol (traces).

StereochemistryHealth Toxicology and MutagenesisRana temporariaCatecholsGlucuronatesResorcinolSulfuric Acid EstersToxicologyHydroxylationBiochemistryHydroxylationchemistry.chemical_compoundPhenolsSalientiaPhenolAnimalsCarbon RadioisotopesChromatography High Pressure LiquidPharmacologyCatecholChromatographybiologyPhenolGeneral MedicineMetabolismResorcinolsbiology.organism_classificationHydroquinoneschemistryGRENOUILLEGlucuronideXenobiotica; the fate of foreign compounds in biological systems
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