6533b7d2fe1ef96bd125e218
RESEARCH PRODUCT
Hydroxylation and conjugation of phenol by the frog Rana temporaria.
J. BeyerG. Franksubject
StereochemistryHealth Toxicology and MutagenesisRana temporariaCatecholsGlucuronatesResorcinolSulfuric Acid EstersToxicologyHydroxylationBiochemistryHydroxylationchemistry.chemical_compoundPhenolsSalientiaPhenolAnimalsCarbon RadioisotopesChromatography High Pressure LiquidPharmacologyCatecholChromatographybiologyPhenolGeneral MedicineMetabolismResorcinolsbiology.organism_classificationHydroquinoneschemistryGRENOUILLEGlucuronidedescription
1. Frogs injected with phenol excrete 67–95% of dose in 15h; 32–87% of dose are metabolites.2. Metabolites identified were phenyl sulphate (15–44% of dose), phenyl glucuronide (10–25% of dose), catechol sulphate (up to 7% of dose), quinol sulphate (1–25% of dose), resorcinol and catechol (traces).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-04-01 | Xenobiotica; the fate of foreign compounds in biological systems |