0000000000173818
AUTHOR
G. Frank
Hydroxylation and conjugation of phenol by the frog Rana temporaria.
1. Frogs injected with phenol excrete 67–95% of dose in 15h; 32–87% of dose are metabolites.2. Metabolites identified were phenyl sulphate (15–44% of dose), phenyl glucuronide (10–25% of dose), catechol sulphate (up to 7% of dose), quinol sulphate (1–25% of dose), resorcinol and catechol (traces).
Metabolism of 3-nitrophenol by the frog Rana temporaria.
1. Frogs injected with 3-nitrophenol excreted 85–93% of the administered dose within 17h; 70–90% dose was metabolized.2. Metabolites identified comprise 3-nitrophenyl glucuronide (57% dose), 3-nitro-phenyl sulphate (24% dose), and 3-acetamidophenyl sulphate (2% dose). Traces of the following metabolites were found: 3-acetamidophenyl glucuronide, 3-acetamidophenol, 4-nitrocatechol, nitroquinol, 4-nitrocatechol sulphate and nitroquinol sulphate.