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RESEARCH PRODUCT
Metabolism of 3-nitrophenol by the frog Rana temporaria.
G. FrankJ. Beyersubject
PharmacologyChromatographyChemistryHealth Toxicology and MutagenesisHydrolysisRana temporariaGeneral MedicineAnatomyMetabolismToxicologyBiochemistryRanaNitrophenolsNitrophenolchemistry.chemical_compoundAnimalsGlucuronideBiotransformationChromatography High Pressure Liquiddescription
1. Frogs injected with 3-nitrophenol excreted 85–93% of the administered dose within 17h; 70–90% dose was metabolized.2. Metabolites identified comprise 3-nitrophenyl glucuronide (57% dose), 3-nitro-phenyl sulphate (24% dose), and 3-acetamidophenyl sulphate (2% dose). Traces of the following metabolites were found: 3-acetamidophenyl glucuronide, 3-acetamidophenol, 4-nitrocatechol, nitroquinol, 4-nitrocatechol sulphate and nitroquinol sulphate.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-04-01 | Xenobiotica; the fate of foreign compounds in biological systems |