Search results for "Gram"
showing 10 items of 9069 documents
The role of endosomal toll-like receptors in bacterial recognition
2012
BACKGROUND: Infections caused by extracellular Gram positive bacteria are still a major health problems. Better understanding of the mechanisms underlying immune responses to these organisms is key to develop pharmacological agents, including vaccines, to control these infections. OBJECTIVE AND PERSPECTIVES: The objective of this review is to highlight the importance of nucleic acid-sensing, intracellular Toll-like receptors in innate immune recognition and in host defenses against extracellular bacteria. CONCLUSIONS: Toll-like receptors 7 and 9 have a major role in inducing host-protective type I interferon responses in conventional dendritic cells in response to streptococci and other ext…
Una experiencia efímera: Enrique de Benito y el Instituto de Estudios Penales de la Universidad de Valencia (1928-1930)
2020
El auge de la Criminología en la segunda mitad del siglo XIX y en los primeros treinta años del XX dio lugar a una pequeña pero importante escuela de criminólogos españoles. El éxito del correccionalismo, junto con la extensión de las teorías de la Escuela Positiva italiana, dio lugar a la creación del Laboratorio de Criminología en Madrid, y la Escuela de Criminología para funcionarios o enseñanzas complementarias al Derecho Penal. En Valencia, la creación del Instituto de Estudios Penales, impulsado por el profesor Enrique De Benito fue una de esas experiencias. De corta trayectoria, el Instituto, con un plantel de profesores multidisciplinar y con un programa que abarcaba los conocimient…
Manufacturers and retailers: A relational analysis
2012
Nowadays, relational models between manufacturers and retailers do not fully reflect the domain of the main relational constructs. This research proposes a model that reflects both affective and attitudinal retailer behaviors from the study of the nomological network between relational value with satisfaction, trust and commitment. The empirical research is based on the study of a Spanish furniture manufacturer with its retailer customers during one furniture fair. Findings suggest that relational value is an antecedent of affective and attitudinal behaviors. Satisfaction with current transactions also appears to be the main determinant of trust and commitment.
Value, satisfaction and loyalty in volunteerism. Application to a religious megaevent
2013
This paper presents a study of the volunteer as an essential agent in the success of any event, and offers recommendations for improving management of megaevents. To achieve this goal we propose a structural model that analyses the multidimensionality of the value concept as antecedent of perceived value, satisfaction and loyalty. The study sample consists of volunteers who participated in the World Youth Day held in Madrid in 2011, obtaining a total number of 1427 cases. The results support all the hypotheses presented in the proposed model. Thus, it confirms that the multidimensionality of the value (spirituality, social value, play and efficiency) is an antecedent of perceived value whil…
Anthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial ac…
2012
Anthemis wiedemanniana is known in folk medicine for the treatment of microbial infections, cancer and also urinary and pulmonary problems. In this study, the chemical composition of the essential oil from A. wiedemanniana was evaluated and its antibacterial activity was tested against 10 bacterial strains. The oil was also tested for its potentiality to inhibit nitric oxide production in RAW 264.7 macrophages and for its cytotoxicity against four human cancer cell lines. A. wiedemanniana oil, rich of oxygenated monoterpenes (25.4%), showed a good antibacterial activity against Gram-positive bacteria and a good activity against the two Gram-negative bacteria, Escherichia coli and Proteus vu…
Antibiotic Resistance of Gram Negatives isolates from loggerhead sea turtles (Caretta caretta) in the central Mediterranean Sea
2009
Previous studies on fish and marine mammals support the hypothesis that marine species harbor antibiotic resistance and therefore may serve as reservoirs for anti biotic-resistance genetic determinants. The aim of this study was to assess the resistance to antimicrobial agents of Gram negative strains isolated from loggerhead sea turtles (Caretta caretta). Oral and cloacal swabs from 19 live-stranded loggerhead sea turtles, with hooks fixed into the gut, were analyzed. The antimicrobial resistance of the isolates to 31 antibiotics was assessed using the disk-diffusion method. Conventional biochemical tests identified Citrobacter spp., Proteus spp., Enterobacter spp., Escherichia spp., Provi…
Defocusing and agentive prepositions in Early Sicilian
2010
In early Italo-Romance two means code the agent in passive constructions: per ‘through’ and da ‘from’. Whilst similarities and differences have never been questioned, I claim that the analysis of prepositions’ semantics is essential to understand agent defocussing strategies. I propose a corpus-based investigation on Early Sicilian (14th century), conducted on Archivio testuale del siciliano antico (, University of Catania). My framework is Cognitive Grammar (Langacker 1991; Luraghi 2003), which interprets prepositions as meaningful elements, expressing the spatial organisation among entities. The agentive value derives from the projection of these spatial relations onto an abstract domain:…
Synthesis and antimicrobial activity of new 3-(1-R-3(5)-methyl-4-nitroso-1H-5(3)-pyrazolyl)-5-methylisoxazoles.
2000
A number of new 3-(1-R-3(5)-methyl-4-nitroso-1H-5(3)-pyrazolyl)-5-methylisoxazoles 6a-g (7b-f) were synthesized and tested for antibacterial and antifungal activity. Some of these compounds displayed antifungal activity at non-cytotoxic concentrations. Derivative 6c was 9 times more potent in vitro than miconazole and 20 times more selective against C. neoformans. 6c was also 8- and 125-fold more potent than amphotericin B and fluconazole, respectively. None of the compounds was active against bacteria. Preliminary structure-activity relationship (SAR) studies showed that the NO group at position 4 of the pyrazole ring is essential for the activity. Lipophilicity of the pyrazole moiety, N-a…
Novel isoquinoline derivatives as antimicrobial agents.
2013
The wide variety of potent biological activities of natural and synthetic isoquinoline alkaloids encouraged us to develop novel antimicrobial isoquinoline compounds. We synthesized a variety of differently functionalized 1-pentyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines (THIQs), including dihydroisoquinolinium salts (2 and 5), methyl pentanoate-THIQ (6), 1-pentanol-THIQ (7), ester derivatives (8-15) and carbamate derivatives (16-23). We employed classic intramolecular Bischler-Napieralski cyclodehydration to generate the isoquinoline core. All the structures were characterized by nuclear magnetic resonance and mass spectrometry. The bactericide and fungicide activities were evaluated f…
Comparison of MALDI-TOF mass spectra with microsatellite length polymorphisms inCandida albicans
2015
Candida albicans is the most frequent yeast involved in human infections. Its population structure can be divided into several genetic clades, some of which have been associated with antifungal susceptibility. Therefore, detecting and monitoring fungal clones in a routine laboratory setting would be a major epidemiological advance. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectra results are now widely used as bar codes to identify microorganisms in clinical microbiology laboratories. This study aimed at testing MALDI-TOF mass spectra bar codes to identify clades among a set of C. albicans isolates. Accordingly, 102 clinical strains were genotyped using 10…