Search results for "Guide"

Italian consensus guidelines for chronic pancreatitis

2010

Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons

2020

Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a truncated CFTR protein and a more severe form of the disease. Aminoglycoside and PTC124 derivatives have been used for the read-through of PTCs to restore the full-length CFTR protein. However, in a precision medicine framework, the CRISPR/dCas13b-based molecular tool &ldquo

Mihi cane et populo: Cicerone e l’autorappresentazione del successo oratorio. La questione del consenso popolare (Cic. Brut. 183–200)

2022

Come si rappresenta il proprio successo? La tradizione poetica greca e latina conosce straordinarie immagini di consacrazioni delle virtù di poeta, elaborate con ricche e ornate costruzioni, la cui persistenza nella memoria letteraria ne assicura la vitalità. A fronte di tali esibizioni virtuosistiche, che dichiarano l’orgoglio del successo, ve ne sono altre, costruite altrettanto finemente ma dall’architettura più complessa, perché fondata su una più mediata strategia. Su una di queste, proveniente da un testo in prosa, ma da un autore quale Cicerone che ambiva non a caso anche al riconoscimento come poeta, vorrei provare a riflettere. Il passo in questione è un’ampia sequenza del Brutus (…

Sustainable conservation: the state of art and the need of guidelines about protection and enjoyment of the archeological Heritage

2019

Within the scientific debate about the conservation, in general, of Cultural Heritage and, in particular, of Archaeological Heritage which are characterized by a dual tangible and intangible nature; and in consistence with Technological Culture for its features concerning the right development and enjoyment of the Heritage, the present essay offers a critical interpretation of the literature about a protection system with an architectural shelter for archaeological sites. On the basis of the critical elements detected in the activities that took place over the past sixty years, this essay underlines the absolute impossibility to postpone the definition of the guidelines which need to be alw…

THE PERFORATED BUILDING’S ENVELOPE: GUIDING THE EARLY DESIGN PHASES

In passato gli involucri edilizi perforati sono stati talvolta ricondotti ad alcuni elementi architettonici tradizionali (come, ad esempio, la ‘Mashrabiyya’), in cui gli elementi forati acquisiscono quasi significati archetipici, nell’assumere ruoli tecnologici e ambientali che rispecchiano i valori della comunità, le condizioni socio-economiche e le esigenze ambientali degli occupanti. Oggi, invece, l’involucro edilizio perforato costituisce una tendenza architettonica che ha iniziato a manifestarsi a livello globale all’inizio del nuovo millennio, alla quale ha contribuito l’emergere della tecnologia digitale con i suoi effetti sull’innovazione di tecniche, materiali, realizzazioni, prest…

Gestión del cuerpo y planificación urbana: Desplazamiento de significado en la reivención de cuepos y ciudades

2020

Contemporary cities have administrations increasingly marked by urban planning guidelines that are guided by business and marketing and, to attract investments and tourists, implement strategies that aim to homogenize, spectacularize and control urban space. However, other experiences in the city potentially build new meaning to it, which would escape those strategically planned, creating alternative possibilities of uses, diverging from the way thar are predicted and proposed by the governmental power in their urban marketing strategies. The article discusses how the occupation of urban spaces by transvestites for prostitution may imply reflections on the role of norms of gender in the (re…

University Faculty Perception of Cyber-Plagiarism: A Virtual Discussion Group

2021

Resumen Este estudio analiza el ciberplagio académico desde la perspectiva del profesorado del Grado en Traducción e Interpretación de la Universidad Internacional de Valencia. Dado que se trata de una práctica fraudulenta cada vez más extendida en las aulas universitarias, se hace necesario que el cuerpo docente reflexione sobre ella para evitar que se convierta en un recurso estructural por parte del alumnado en este nivel educativo. El estudio apuesta por una metodología cualitativa y, en concreto, el grupo de discusión, el cual se lleva a cabo por videoconferencia gracias a la participación de su claustro (n=16). Como instrumento se diseña un guion de seis preguntas a partir de las cual…

Destination image and tourism intermediation. A possible interdisciplinary approach

2009

The novice language teacher's guide to survival : dialogue between the new and the experienced language teacher

2017

Aloittelevat opettajat kohtaavat ammatissaan merkittävän määrän haasteita ensimmäisien työvuosien aikana (Blomberg 2009; Heikkinen et al. 2012; Laaksola 2007). Haasteita ovat muun muassa psykologiset aspektit kuten identiteetin muodostaminen ja stressi (Kyriacou 2001; Niemi 1998), sekä ulkoiset tekijät kuten opettajiin kohdistuvat ristiriitaiset odotukset ja alati muuttuva työympäristö (Luukkainen 2005; Niemi 1999). Idea tarjota tukea aloittelevalle opettajalle syntyi kirjoittajien omista kokemuksista ja keskusteluista koskien aloittelevan opettajan asemaa. Monia kollegojamme huolestutti opetusharjoittelujakson pituus, ja moni tuleva aineenopettaja koki, ettei ollut valmis kohtaamaan kielen…

Discrete exterior calculus for photonic crystal waveguides

2022

The discrete exterior calculus (DEC) is very promising, though not yet widely used, discretization method for photonic crystal (PC) waveguides. It can be seen as a generalization of the finite difference time domain (FDTD) method. The DEC enables efficient time evolution by construction and fits well for nonhomogeneous computational domains and obstacles of curved surfaces. These properties are typically present in applications of PC waveguides that are constructed as periodic structures of inhomogeneities in a computational domain. We present a two-dimensional DEC discretization for PC waveguides and demonstrate it with a selection of numerical experiments typical in the application area. …