Search results for "Gun"

Implantations, activités et relations des établissements d'assistance en Bourgogne à la fin du Moyen Age

2012

The study presented here is the conclusion of an inventory about hospitals having existed on the territory of some dioceses (Autun, Auxerre, Chalon-sur-Saône, Nevers and the south of that of Langres diocese) between XIIth and XVth centuries. Based on the data collected, an atlas of assistance and a directory of sources on medieval hospitals of the study area has been made. The compiled informations proved to be very different but also very heterogeneous. Nevertheless, reflexions were conducted about the characteristics of these hospitals and their relationships with their economic, religious, political and social environments. It revolves around three parts dealing by turns the influence of…

Al via la V edizione del Premio Internazionale Arte Laguna

2010

"Valores, funciones y estrategias de la prensa del exilio. El caso de Izquierda Republicana (México, D.F.)"

2011

International audience

Élites políticas en transición. España de 1875 a 1975

2008

Entre 1876 y 1976 la élite política española fue sustituida por una nueva. En este artículo se presta atención principalmente a los políticos de UCD-Valencia durante la Transición. Concluimos que la permanencia de la élite política tradicional es muy escasa, aunque sigan detentando influencia económica y social que les viene de familia. (A)

Prediction of a Missing Protein Expression Map in the Context of the Human Proteome Project

2015

Experimental evidence for the entire human proteome has been defined in the Human Proteome Project, and it is publicly available in the neXtProt database. However, there are still human proteins for which reliable experimental evidence does not exist, and the identification of such information has become one of the overriding objectives in the chromosome-centric study of the human proteome. With this aim and considering the complexity of protein detection using shotgun and targeted proteomics, the research community has addressed the integration of transcriptomics and proteomics landscapes. Here, we describe an analytical pipeline that predicts the probability of a missing protein being exp…

A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete.

2015

We report the genome sequence of Planobispora rosea ATCC 53733, a mycelium-forming soil-dweller belonging to one of the lesser studied genera of Actinobacteria and producing the thiopeptide GE2270. The P. rosea genome presents considerable convergence in gene organization and function with other members in the family Streptosporangiaceae, with a significant number (44%) of shared orthologs. Patterns of gene expression in P. rosea cultures during exponential and stationary phase have been analyzed using whole transcriptome shotgun sequencing and by proteome analysis. Among the differentially abundant proteins, those involved in protein metabolism are particularly represented, including the G…

Fungal proteins in the extra-radical phase of arbuscular mycorrhiza: a shotgun proteomic picture

2009

International audience

An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells

2020

Abstract The organometallic AuI bis‐N‐heterocyclic carbene complex [Au(9‐methylcaffeine‐8‐ylidene)2]+ (AuTMX2) was previously shown to selectively and potently stabilise telomeric DNA G‐quadruplex (G4) structures. This study sheds light on the molecular reactivity and mode of action of AuTMX2 in the cellular context using mass spectrometry‐based methods, including shotgun proteomics in A2780 ovarian cancer cells. In contrast to other metal‐based anticancer agents, this organogold compound is less prone to form coordinative bonds with biological nucleophiles and is expected to exert its drug effects mainly by non‐covalent interactions. Global protein expression changes of treated cancer cell…

Spanish human proteome project: Dissection of chromosome 16

2013

11 páginas, 6 figuras.-- et al.

Feasibility of shotgun urinary proteomics for investigating prematurely born preschoolers (PBP)

2016

Background: Preterms and twins are at higher risk of respiratory morbidity later in life. Advances in proteomic approaches may allow the characterization of biomarkers involved in respiratory diseases (Mauri et al. Imm. Lett. 2014;162:2-10). Gel-free approach quantitatively identify differentially expressed proteins in relation to physiopathological conditions (Mauri&Dehò, Meth Enzymology 2008;447:99-117). This can improve the clinical reliability of the next generation of biomarkers to discriminate multiple phenotypes of childhood respiratory diseases. Aim: To assess the ability of gel-free proteomics for identifying specific protein profiles related to PBP. Methods: Urine samples were…