Search results for "Gènes"
showing 10 items of 66 documents
GeneSys-Beet: A model of the effects of cropping systems on gene flow between sugar beet and weed beet
2008
A weedy form of the genus Beta, i.e. Beta vulgaris ssp. vulgaris (hence ''weed beet'') frequently found in sugar beet is impossible to eliminate with herbicides because of its genetic proximity to the crop. It is presumed to be the progeny of accidental hybrids between sugar beet (ssp. vulgaris) and wild beet (ssp. maritima), or of sugar beet varieties sensitive to vernalization and sown early in years with late cold spells. In this context, genetically modified (GM) sugar beet varieties tolerant to non-selective herbicides would be interesting to manage weed beet. However, because of the proximity of the weed to the crop, it is highly probable that the herbicide-tolerance transgene would b…
Angiogenic response in an in vitro model of dog microvascular endothelial cells stimulated with antigenic extracts from Dirofilaria immitis adult wor…
2019
Abstract Background Angiogenesis can occur under pathological conditions when stimuli such as inflammation, vascular obstruction or hypoxia exist. These stimuli are present in cardiopulmonary dirofilariosis (Dirofilaria immitis). The aim of this study was to analyze the capacity of D. immitis antigens to modify the expression of angiogenic factors and trigger the formation of pseudocapillaries (tube-like structures) in an in vitro model of endothelial cells. Methods The expression of VEGF-A, sFlt, mEndoglin and sEndoglin in cultures of canine microvascular endothelial cells stimulated with extract of adult worms of D. immitis obtained from an untreated dog (DiSA) and from a dog treated for …
Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study.
2015
Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at cytosine-phosphate-guanine (CpG) site level and genomic regions. A discovery cross-sectional epigenome-wide association study nested in the follow-up of the REGICOR cohort was designed and included 645 individuals. Blood DNA methylation was assessed using the Illumina HumanMethylation450 BeadChip. Smoking status was self-reported using a standardized questionnaire. We identified 66 differentially methylated CpG sites associated with smoking, located in 38 genes. In most of …
Transcriptome analysis revealed that a quorum sensing system regulates the transfer of the pAt megaplasmid in Agrobacterium tumefaciens.
2016
Background Agrobacterium tumefaciens strain P4 is atypical, as the strain is not pathogenic and produces a for this species unusual quorum sensing signal, identified as N-(3-hydroxy-octanoyl)-homoserine lactone (3OH,C8-HSL). Results By sequence analysis and cloning, a functional luxI-like gene, named cinI, has been identified on the At plasmid of A. tumefaciens strain P4. Insertion mutagenesis in the cinI gene and transcriptome analyses permitted the identification of 32 cinI-regulated genes in this strain, most of them encoding proteins responsible for the conjugative transfer of pAtP4. Among these genes were the avhB genes that encode a type 4 secretion system (T4SS) involved in the forma…
Les ambroisies annuelles (Ambrosia artemisiifolia et Ambrosia trifida) : réponse adaptative au désherbage chimique et connectivité des populations da…
2018
The primary aim of this work was to study the risk of resistance evolution to acetolactate synthase (ALS) inhibiting herbicides in mugwort (Ambrosia artemisiifolia L.) through four points: (i) selection pressure (study of the efficacy of a range of ALS-inhibiting herbicides), (ii) the adaptive response capacity of the weed (determination of the variation in sensitivity to ALS inhibitors between plants and implementation of a recurrent selection programme), (iii) a field study (search for resistance to ALS inhibitors in the field in France), (iv) the study of resistance mechanisms (target-linked - TLR - and non-target-linked - NLR - by a transcriptomics approach). The second objective was to…
Història de Josef, fill de Jacob
Sign.: a-b8, c10. - Data aprox., 1500 L. gòt. - 2 mides. - 31 lín. - Capll. grav. - Filigr.: balança encerclada
Bíblia. Gènesi. Llatí
Ms. il·luminat Títol donat pel catalogador Col·lació: Vitel·la, f. i (pergamí actual) i (paper) + 203 + i (pergamí actual) i (paper) ; numeració moderna a llapis Composició: Text de la Bíblia i dels comentaris en dues o tres columnes, amb nombre de línies variable i l'últim full a línea tirada ; pautat amb mina de plom Escriptura: Gòtica textual cal·ligràfica Decoració: Caplletres miniades amb motius antropomòrfics i vegetals. Calderons, titolets i majúscules alternant tintes de color blau i vermell Enquadernació: Restaurada, plateresca, pell verda sobre fusta amb ferros freds. En la coberta anterior, amb ferros daurats, l'escut d'armes del duc de Calàbria entre florons; hi manquen els ferm…
Bíblia. Gènesi. Llatí
Ms. il·luminat Títol donat pel catalogador Col·lació: Vitel·la, f. ii (paper) + 189 + iii (paper) ; numeració moderna a llapis Composició: Text escrit a línia tirada, dues i tres columnes, amb nombre de línies variable. Pautat amb mina de plom Escriptura: Gòtica textual cal·ligràfica. Nombroses anotacions marginals d'època medieval Decoració: Al començament de cada llibre caplletres il·luminades i decorades am motius vegetals i zoomòrfics. Calderons i titolets alternant tintes de color blau i vermell Enquadernació: Original, pell marró sobre fusta, de rodes amb ferros freds. En la coberta anterior, amb ferros daurats, l'escut d'armes del duc de Calàbria entre florons; restes dels fermalls o…
Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers
2015
Abstract Analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed regional DNA hypermethylation embedded in extensive global hypomethylation. In contrast to the widely reported DNA hypermethylation of promoter-associated CpG islands (CGIs) in cancer, hypermethylated sites in MM as compared to normal plasma cells were located outside CpG islands and were unexpectedly associated with intronic enhancer regions active in normal B cells. Both RNA-seq and in vitro reporter assays indicated that enhancer hypermethylation is globally associated with downregulation of its host genes. ChIP-seq and DNAseI-se…
International network of cancer genome projects
2010
International audience; The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of over 25,000 cancer genomes at the genomic, epigenomic, and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically-relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.