Search results for "H'"

Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich ataxia

2016

Frataxin (FXN) deficiency causes Friedreich's ataxia (FRDA), a multisystem disorder with neurological and non-neurological symptoms. FRDA pathophysiology combines developmental and degenerative processes of dorsal root ganglia (DRG), sensory nerves, dorsal columns and other central nervous structures. A dying-back mechanism has been proposed to explain the peripheral neuropathy and neuropathology. In addition, affected individuals have non-neuronal symptoms such as diabetes mellitus or glucose intolerance. To go further in the understanding of the pathogenic mechanisms of neuropathy and diabetes associated with the disease, we have investigated the humanized mouse YG8R model of FRDA. By bio…

The impact of the 2015/2016 El Niño on global photosynthesis using satellite remote sensing

2018

The El Niño-Southern Oscillation exerts a large influence on global climate regimes and on the global carbon cycle. Although El Niño is known to be associated with a reduction of the global total land carbon sink, results based on prognostic models or measurements disagree over the relative contribution of photosynthesis to the reduced sink. Here, we provide an independent remote sensing-based analysis on the impact of the 2015–2016 El Niño on global photosynthesis using six global satellite-based photosynthesis products and a global solar-induced fluorescence (SIF) dataset. An ensemble of satellite-based photosynthesis products showed a negative anomaly of −0.7 ± 1.2 PgC in 2015, but a sli…

CO2 flux emissions from the Earth's most actively degassing volcanoes, 2005-2015

2019

AbstractThe global carbon dioxide (CO2) flux from subaerial volcanoes remains poorly quantified, limiting our understanding of the deep carbon cycle during geologic time and in modern Earth. Past attempts to extrapolate the global volcanic CO2 flux have been biased by observations being available for a relatively small number of accessible volcanoes. Here, we propose that the strong, but yet unmeasured, CO2 emissions from several remote degassing volcanoes worldwide can be predicted using regional/global relationships between the CO2/ST ratio of volcanic gases and whole-rock trace element compositions (e.g., Ba/La). From these globally linked gas/rock compositions, we predict the CO2/ST gas…

Psychometric properties of the Persian version of the nutritional form for the elderly (NUFFE) in nursing home residents

2018

Background: The Nutritional Form for the Elderly (NUFFE) is a newly developed tool. This study aimed to carry out a psychometric evaluation of the Persian version of NUFFE (NUFFE-P) among nursing home residents. Methods: Nursing home participant’s aged ≥ 60 years (n=97) were enrolled. The inclusion criteria were residency for at least 6 months in the nursing home, and ability to communicate. Exclusion criteria included cognitive impairment, having depressed mood, severe hearing loss, problems in upper and lower extremities also, history of hospital admission during 6 months before enrollment. Anthropometric measures, laboratory tests, three-day food intake, NUFFE-P version, Mini Nutritional…

Validation of the Satisfaction Questionnaire with physical education classes (CSCEF) in the Latin American context

2020

The objective of this study was to validate the Satisfaction Questionnaire in Physical Education Classes (CSCEF) in the context of Latin America (Dominican Republic). 1298 students aged between 15 and 21 participated. The psychometric properties of the instrument were analysed. The results demonstrated that the best factor solution would be a multidimensional model represented by nine dimensions for the satisfaction construct, as well as a higher-order model. According to Cronbach's alpha and omega index, values between .66 and .99 were obtained. The Latin American version of the CSCEF was invariant with respect to gender. Although the results of this study support the validity and reliabil…

Validación de una versión reducida en español del instrumento Barriers to Physical Activity Questionnaire for People with Mobility Impairments

2018

Objetivo. Validar una versión reducida en español del ins­trumento Barriers to Physical Activity Questionnaire for People with Mobility Impairments (BPAQ-MI), aplicable a diferentes tipos de discapacidad. Material y métodos. El cuestio­nario fue aplicado a 791 universitarios con discapacidad. La estructura factorial se validó mediante un análisis factorial confirmatorio y, para valorar la validez criterial, se llevaron a cabo correlaciones de Spearman. La fiabilidad se evaluó mediante el coeficiente alfa de Cronbach. Resultados. El modelo propuesto reveló buenos índices de ajuste y una ex­celente consistencia interna (α=0.920). Surgieron relaciones negativas entre las barreras experimentada…

Development and validation of the Healthy-Unhealthy Music Scale.

2015

Background Music is an integral part of life in youth, and although it has been acknowledged that musical behavior reflects broader psychosocial aspects of adolescent behavior, no measurement instruments have been specifically designed for assessing musical engagement as an indicator of adolescent wellbeing and/or symptomatology. This study was conducted in order to develop and validate a scale for assessing musical engagement as an indicator of proneness for depression in youth. Method Items were developed based on the literature and a prior grounded theory analysis and three surveys (N = 54, N = 187, N = 211) were conducted to select, refine, test, and validate the items. Scale structure …

Compassion-based meditation quality practice and its impact on the positive attitudes toward others

2021

Objectives: The authors report on the initial development and validation of the Compassion Practice Quality Scale (CPQS), a measure to assess the quality of compassion-based meditation (CBM). It is conceptualized and operationalized via two factors measuring mental imagery and somatic perception/response. Methods: The total sample was composed of 205 university students who underwent a CBM and completed pre-test/post-test assessment of compassion and related constructs. Results from a series of preliminary psychometric analyses of the CPQS were examined, including factor analysis, internal consistency, and convergent/discriminant validity. Results: The data supported a 12-item and 10-item (…

2019

Background The SCL-K-9 is the latest short version of the multidimensional Symptom-Checklist 90-R. Up to now, its psychometric properties have not been clarified sufficiently as the nine items have not yet been presented exclusively in a representative sample. Therefore, psychometric properties, model fit values as well as norm-values were analyzed. Methods For the sample, N = 2,507 participants aged 14 to 92, n = 1,379 women and n = 1,128 men, and a mean age of 48.79 (SD = 17.91), were selected from the general population by random-route sampling. Confirmatory factor analyses applying full information maximum likelihood (FIML) tested the model fit. The reliability estimations and effect si…

Assessment of proneness to distraction: English adaptation and validation of the Attention-Related Driving Errors Scale (ARDES) and cross-cultural eq…

2016

Abstract Prior research developed the Attention-Related Driving Errors Scale (ARDES), a 19-item questionnaire aimed at evaluating the drivers’ predisposition to attentional error, and also provided validity evidence of ARDES measures across two countries: Argentina and Spain. In the current work we adapt the Spanish version of the ARDES to the English language and the culture, traffic regulations and driving habits of the UK, and then provide new evidence of the cross-cultural equivalence of the scale. First, an improved forward and backward translation design was used to translate the Spanish ARDES into English. A committee-approach review process was also performed during the translation …