Search results for "H.P.M."
showing 10 items of 738 documents
Exploring web-mediated communication: A genre-based linguistic study for new patterns of doctor–patient interaction in online environment
2016
This paper questions the nature of the communicative event that takes place in online contexts between doctors and web-users, showing computer-mediated linguistic norms and discussing the nature of the participants’ roles. Based on an analysis of 1005 posts occurring between doctors and the users of health service websites, I analyse how doctor–patient communication is affected by the medium and how health professionals overcome issues concerning the virtual medical visit. Results suggest that (a) online medical answers offer a different service from that expected by users, as doctors cannot always fulfill patient requests, and (b) net consultations use aspects of traditional doctor–patient…
IMPLEMENTING SERVICES IN PRICING DECISIONS TO ENHANCE THE CUSTOMER RELATIONSHIP — A FRAMEWORK FOR PRICE SETTING
2008
AbstractThis study develops a pricing framework that focuses on relationship-building — a factor that has been largely ignored in the pricing literature. First, a case-study method has been employed to better understand how a production-oriented company sets prices for its products. Then a framework has been developed which incorporates the service component in the pricing equation. The results of this research suggest that factoring in the price for services offered can enhance relationship management, thus having a positive impact on the company's business performance.
The Structure and Formation of Customer value in B-to-B Services
2017
This study investigates the hierarchical construct and the formation of customer value of b-to-b services. In-depth understanding of the construction of customer value and the effects of service quality on customer value are the key to effective development of b-to-b services. This quantitative study was conducted through the structured interview method among Finnish business organizations in early 2009. The data consisted of 90 qualified questionnaires. The customer value of b-to-b services was found to be composed of attribute and consequence levels. The dimensions of service quality influenced to differing degrees the formation of the attribute and consequence levels of the customer valu…
Customer Satisfaction and Quality Services in the Hotel Industry: A Strategic Approach
2018
In the hotel and hospitality industry, managers need to see quality as their main competitive advantage and need the acknowledge the ways in which quality can be used to drive competitiveness. As one of the most important aspects of hotel management and customer relationship management, the quality of all touristic services influenced by the intensifying competition, determine suppliers to take into account more the needs and requirements of customers in order to have a successful strategy. In the digital world where consumers are well-informed, the choice to purchase best quality services is the ultimate choice given the opportunity to compare other services with other companies. Both mana…
Exploring the links between destination attributes, quality of service experience and loyalty in emerging Mediterranean destinations
2020
Abstract Since the publication of the “Experience Economy” work by Pine and Gilmore in 1999, understanding the increasing complexity of the customer experience within the customer journey in the tourism industry is a priority for researchers and destination management organizations. This study contributes to the extension of the Experience Economy in tourism research by examining the links between tourists' assessment of destination attributes, their perceived quality of the service experience and loyalty, in seven emerging Mediterranean destinations. To date, little research has explored the aforementioned aspects, even though the Mediterranean region is the leading tourism destination in …
Current Software-as-a-Service Business Models: Evidence from Finland
2012
This paper characterizes the business models of Software-as-a-Service (SaaS) firms based on their value proposition, customer segments, revenue streams, and customer relationship, and analyzes interconnections of these business model elements. The target set of 163 Finnish SaaS and ASP firms was first compared to other software firms and then clustered into four clusters based on indicator data of their business model elements. The comparison reveals that the SaaS and ASP firms have smaller customer and transaction sizes than software firms in general. The resulting classification reveals two different configurations, a pure-play SaaS model and an enterprise SaaS model, and the typical fact…
Global DNA Hypomethylation following 5-aza-2'-deoxycytidine treatment induces aneuploidy in HCT-116 tumor cells.
2013
Aneuploidy, the alteration of the normal number of chromosomes, is found in most of the human solid tumors and correlated with to defects in the process of chromosome segregation (1). It was also suggested that the alteration of the 5-methylcytosine (5-mC) pattern in the chromosome pericentromeric region, generated to aneuploid cells (2, 3). To investigate the relationship between hypomethylation and whole chromosome aneuploidy, we treated HCT-116 cells, a near diploid line, with the demethylating agent 5-aza- 2'-deoxycytidine (DAC). The treatment with DAC for 24, 48 and 72 hours produced a progressive reduction of DNA methylation as shown by decrease of 5-mC signal. DNA hypomethylation res…
Metilazione del DNA in artrite reumatoide
2005
Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…
The urban rent in the multicultural city: retail shops, migrants and urban decline in the historic centre of Palermo
2020
La diffusione di nuove modalità di vendita al dettaglio, come gli shopping mall, i megastore e l’e-commerce, hanno modificato i tradizionali modelli localizzativi di immobili a destinazione commerciale, incidendo anche sulle connotazioni del tessuto urbano ed extraurbano e sulla distribuzione spaziale della rendita. Anche le zone centrali delle città hanno subito trasformazioni significative, che a volte si traducono in un vero e proprio declino, soprattutto in presenza di sistemi economici locali deboli e di mercati immobiliari in recessione. Una quota rilevante di immobili a destinazione commerciale può rimanere a lungo non utilizzata per eccesso di offerta sulla domanda, poiché a fronte …
I vescovati nella Sicilia normanna (secc. XI-XIII). Potestà normative e competenze giurisdizionali in un territorio multiculturale
2022
In Sicilia, durante l’età normanna (1060-1194), la progressiva costruzione di un rinnovato apparato politico-istituzionale, cominciata a partire dalla conquista dell’isola, si svolse in parallelo con la ricostituzione dei distretti diocesani, definitivamente scomparsi a seguito del plurisecolare dominio musulmano. Questa monografia racchiude i risultati di una ricerca condotta con l’obiettivo di analizzare complessivamente le fonti superstiti relative ai vescovati siciliani, a partire dalla fine dell’XI secolo sino alle soglie del mutamento dinastico che sancì l’avvento dell’età sveva. Nonostante la disomogeneità dei dati a disposizione, emerge come nel corso di poco più di un secolo, il ru…