Search results for "H1"
showing 10 items of 1219 documents
Distinct Roles for IL-1 Receptor Type I Signaling in Early Versus Established Leishmania major Infections
2006
IL-1alpha/beta released by infected dendritic cells (DC) plays a critical role in the development of protective immunity against Leishmania major. Previous studies demonstrated that treatment of susceptible BALB/c mice with IL-1alpha during T-cell priming (days 1-3 post-infection) induced T helper (Th)1-mediated protection. In contrast, we now demonstrate that prolonged treatment with IL-1alpha (for 3 weeks) worsened disease outcome. To characterize the receptor involved, L. major infections in IL-1 receptor type I (IL-1RI) knockout mice were studied. In C57BL/6 IL-1RI-/- mice, the IL-1alpha-mediated protective effect was abrogated. The course of high-dose infection (2 x 10(5) parasites) in…
Algebraic groups as difference Galois groups of linear differential equations
2019
We study the inverse problem in the difference Galois theory of linear differential equations over the difference-differential field $\mathbb{C}(x)$ with derivation $\frac{d}{dx}$ and endomorphism $f(x)\mapsto f(x+1)$. Our main result is that every linear algebraic group, considered as a difference algebraic group, occurs as the difference Galois group of some linear differential equation over $\mathbb{C}(x)$.
La metáfora bélica durante la crisis sanitaria de la gripe A
2011
This article aims to illustrate how became a fundamental communicative resource for the mass media when reporting on the H1N1 virus during the swine flu health crisis. This analogy heightened public fear so much so that many individuals demanded that the government acquire certain drugs and vaccines to protect themselves from the virus. This research is based on the information which appeared in three national dailies –El Pais, El Mundo and ABC– over a six-month period, as well as academic publications, documents and articles available in the media and Internet.
Gram-positive bacteria on grass pollen exhibit adjuvant activity inducing inflammatory T cell responses.
2011
BACKGROUND: Recently, it has been established that pollen grains contain Th2-enhancing activities besides allergens. OBJECTIVE: The aim of this study was to analyse whether pollen carry additional adjuvant factors like microbes and what immunological effects they may exert. METHODS: Timothy pollen grains were collected and disseminated on agar plates, and the growing microorganisms were cultivated and defined. Furthermore, the immunologic effects of microbial products on DC and T cell responses were analysed. RESULTS: A complex mixture of bacteria and moulds was detected on grass pollen. Besides Gram-negative bacteria that are known to favour Th1-directed immune responses, moulds were ident…
NFATc1 Induction in Peripheral T and B Lymphocytes
2013
Abstract NFAT transcription factors control the proliferation and survival of peripheral lymphocytes. We have reported previously that the short isoform NFATc1/αA whose generation is induced by immune receptor stimulation supports the proliferation and inhibits the activation-induced cell death of peripheral T and B cells. We will show in this study that in novel bacterial artificial chromosome transgenic mice that express EGFP under the control of entire Nfatc1 locus the Nfatc1/Egfp transgene is expressed as early as in double-negative thymocytes and in nonstimulated peripheral T and B cells. Upon immune receptor stimulation, Nfatc1/Egfp expression is elevated in B, Th1, and Th2 cells, but…
Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and …
2002
Co-administration of CpG-containing immunostimulatory oligodeoxynucleotides and parasite antigen protects susceptible BALB/c mice from otherwise progressive infection with Leishmania major. Although the protective effect of CpG-containing immunostimulatory oligodeoxynucleotides is clearly dependent on endogenous interleukin-12 and interferon-gamma production, the source of these Th1-promoting cytokines in infected mice is unknown. In contrast to macrophages from Leishmania-resistant C57BL/6 mice, macrophages from susceptible BALB/c mice are hyporesponsive to stimulation with lipopolysaccharide and interferon-gamma. While studying interactions of various antigen-presenting cells with Leishma…
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release
2013
AbstractInflammation results in the production of free radicals. We evaluated the anti-inflammatory and antioxidant capacity of lipoic acid in an experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis rats. The role of oxidative stress in the endotoxin-induced uveitis model is well-known. Besides, the Th1 response classically performs a central part in the immunopathological process of experimental autoimmune uveitis. Exogenous sources of lipoic acid have been shown to exhibit antioxidant and anti-inflammatory properties. Our results show that lipoic acid treatment plays a preventive role in endotoxin-induced oxidative stress at 24 h post-administration and reduced…
Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock.
2007
Abstract α−galactosylceramide, a natural killer T cell ligand, and its synthetic homolog, KRN7000, consistently influence IFN-γ and TNF-α release, both mediators of LPS-induced shock. To modify the course of endotoxin shock, we injected KRN7000 at different time points of experimental systemic Shwartzman reaction. Mice treated with KRN7000 survived when it was injected within 2 h before and after LPS challenge. Mice survival was associated with low levels of T helper 1 (Th1) cytokines, such as IFN-γ and TNF-α. By contrast, protection from endotoxin shock was associated with an increase of T helper 2 (Th2) cytokines, like IL-4 and IL-10. A role of Th2 cytokines in counteracting LPS-induced s…
Agencias de empleo y desarrollo local: ¿una actividad del Tercer Sector?
2010
Ricardo.Calvo@uv.es En la actualidad, el desarrollo económico y social de un territorio necesita de los esfuerzos mancomunados de todos y cada uno de los agentes presentes en el medio. Es por ello que el presente artículo pretende reflexionar sobre la vinculación directa existente entre dos de ellos, por un lado las Agencias de Desarrollo Local –ADL’scomo máximo exponente del modelo de desarrollo local y por otro las organizaciones pertenecientes al Tercer Sector, como entidades clave en el sostenimiento y desarrollo social de la comunidad. Para ello partiendo de las características propias del modelo actual de desarrollo local implantado, propondremos dos decálogos de conclusiones, que ana…
Frontline Professionals Performing Collaborative Work with Low-Income Families: Challenges across Organizational Boundaries
2020
This article discusses certain challenges relating to interagency collaboration between the Norwegian Labour and Welfare Administration (NAV) and Child Welfare Services (CWS). We have asked what obstacles to holistic work with low-income families who receive measures from NAV and CWS simultaneously can be identified. The departure point is collaboration on a local project at the municipal level. The differences between the views of the individual services (and the mandates based on these views) with regard to parental obligations have proved challenging. Using the theory of institutional logic, we have explored how different logics have influenced these services’ approaches to parenthood an…