6533b7d5fe1ef96bd1265286
RESEARCH PRODUCT
Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release
Francisco Bosch-morellAmparo NaveaMaría MuriachSalvador MéridaMaría MirandaMaría Sancho-tellosubject
LipopolysaccharidesMaleAntioxidantantioxidantLipopolysaccharidemedicine.medical_treatmentInflammationPharmacologymedicine.disease_causeBiochemistryAntioxidantsUveitischemistry.chemical_compoundSubcutaneous injectionmedicineAnimalsInflammationTh1 lymphocytesTh2 lymphocytesThioctic AcidChemistryAnti-Inflammatory Agents Non-SteroidalGeneral MedicineTh1 Cellsmedicine.diseaselipoic acidcytokinesRatsCellular infiltrationLipoic acidDisease Models AnimalRats Inbred LewImmunologyuveitisCytokineslipids (amino acids peptides and proteins)medicine.symptomOxidative stressUveitisdescription
AbstractInflammation results in the production of free radicals. We evaluated the anti-inflammatory and antioxidant capacity of lipoic acid in an experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis rats. The role of oxidative stress in the endotoxin-induced uveitis model is well-known. Besides, the Th1 response classically performs a central part in the immunopathological process of experimental autoimmune uveitis. Exogenous sources of lipoic acid have been shown to exhibit antioxidant and anti-inflammatory properties. Our results show that lipoic acid treatment plays a preventive role in endotoxin-induced oxidative stress at 24 h post-administration and reduced Th1 lymphocytes-related cytokines by approximately 50–60%. Simultaneously, lipoic acid treatment caused a significant reduction in uveal histopathological grading and in the protein concentration in aqueous humors, but not in cellular infiltration.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-06-13 |