Search results for "H1"

Stepwise Regulation of TH1 Responses in Autoimmunity: Il-12-Related Cytokines and Their Receptors

2005

Interleukin (IL)-12 is a key cytokine of cell-mediated immune responses. Until recently, IL-12 was believed to be unique in its ability to induce the differentiation of naive T cells toward the TH1 phenotype and in its pathogenic activity, as shown in various disease models including inflammatory bowel disease. However, recently, 2 additional cytokines closely related to IL-12, IL-23 and IL-27, were discovered. Until then, the role of IL-12 was overestimated because it was believed that the p40 subunit was unique to IL-12. The discovery that IL-12 shares p40 with IL-23 and that IL-23 but not IL-12 is essential in models of chronic inflammation and autoimmunity led to a model in which IL-12 …

Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy

2019

Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually.Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza.Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) again…

Changes from 1986 to 2006 in reasons for liking leisure-time physical activity among adolescents

2016

Reasons for participating in physical activity (PA) may have changed in accordance with the general modernization of society. The aim is to examine changes in self-reported reasons for liking leisure-time physical activity (LTPA) and their association with self-reported LTPA over a 20-year period. Data were collected among nationally representative samples of 13-year-olds in Finland, Norway, and Wales in 1986 and 2006 (N = 9252) as part of the WHO cross-national Health Behaviour in School-aged Children (HBSC) study. Univariate ANOVAs to establish differences according to gender, year, and country were conducted. In all countries, 13-year-olds in 2006 tended to report higher importance in te…

Evolucion paleoambiental desde el Holoceno temprano hasta la actualidad del marjal de Almenara (Mediterráneo occidental)

2018

The main aim of this study is to characterize the different stages in the palaeoenvironmental evolution of the Almenara marsh, Spain, from the early Holocene to the present day. This marsh is one of the most important in Castellón province. Five cores extracted from the marsh underwent sedimentological analysis, micropalaeontological study (foraminifera, ostracods and gastropods) and 14C dating. The results show that before the maximum transgression of the Mediterranean during the Marine Isotope Stage 1 (5500 cal yr. BP dating in the Almenara marsh), the area was occupied by a brackish marsh (prior to the 8.2 ka event). During the middle Holocene, the regional sea level rise and later stabi…

“How innovation in knowledge reduces food destruction and hunger in the world”. Presentation of the volume

2017

Transition towards a tourist innovation model: The smart tourism destination

2020

Implantation of the smart city model in intermediate tourist towns on their transition to becoming smart destinations involves an inescapable commitment to their habitat and improving the quality of civic life and the economy of cities through more sustainable and technologically advanced elements. Based on this work, the aim is to achieve an overview of the current smart cities paradigm from the standpoint of territorial interest groups, by analysing a tourist town on the Mediterranean coast (Gandia, Valencia) to diagnose its current status. The ultimate aim is to answer the question of whether these intermediate tourist cities are in a position to align themselves with the necessary requi…

Cost-cutting actions, employment relations and workplace grievances: Lessons from the 2008 financial crisis

2022

Periods of economic recession are typically accompanied by the use of cost-cutting actions, such as wage cuts or freezes, increased workloads and reduced training expenditures. While such actions are expected to boost performance, at least in the short-term, their effects on employee attitudes and behaviours at work have been the subject of much research. In this study, we examine how management's use of cost-cutting actions could have a detrimental impact on two aspects of the employment relations climate—the quality of employee–management relations and the level of employees’ trust in management; further, we investigate how these relationships might lead to an increase in employee complai…

VIAGENS E LEITURAS JAPONESAS EM RAKUSHISHA, DE ADRIANA LISBOA

2014

Resumo: No romance Rakushisha (2007), Adriana Lisboa representa varias dimensoes da experiencia da alteridade. Os dois protagonistas brasileiros que viajam ao Japao – Haruki em busca de suas raizes culturais, Celina em busca dela mesma – refletem a estadia da propria autora em Quioto, experiencia necessaria para poder escrever o livro, como afirma ela. A viagem do protagonsitas ao Japao tambem funciona como guia para os leitores na descoberta e no dialogo com as obras dos poetas japoneses Matsuo Bashō (1644-1694) e Sei Shōnagon (966-1025) – particularmente o Saga Nikki e o Livro de cabeceira – assim como a experiencia do Japao relatada por Roland Barthes em L’Empire des signes . Abstract: I…

Calculation of vibrationally resolved absorption and fluorescence spectra of the rylenes

2020

A generating function method was used to simulate the vibrationally resolved absorption and emission spectra of perylene, terrylene and quaterrylene. This method operates on the basis of adiabatic excitation energies and electronic ground and excited state vibrational frequencies. These parameters were calculated using density functional theory with the PBE0 functional for perylene and terrylene and with the BH-LYP functional for quaterrylene. The vertical excitation energies of the lower excited states were calculated using functionals with differing amounts of Hartree-Fock exchange. The optimal functional for each molecule was chosen by comparing these energies to literature excitation en…

Thermosetting composites based on bronze particles for archaeological and artistic metal heritage cloning

2018

peer-reviewed Artificial Metals are polymeric semi-metallic composites obtained by combining thermosetting resins with atomized metal powders in order to achieve composite materials capable of reproducing metals, even in a rusty or corroded condition. These composites provide a solution for the reproduction of archaeological artefacts, sculptures, and ornaments for the purpose of conservation. This work explores mechanical properties of three different resins bronze composites loaded with two different proportions of metal filler. The degree of conversion of the samples was measured by differential scanning calorimetry (DSC) and flexural tests were carried out to determine their mechanical …