Search results for "H1"
showing 10 items of 1219 documents
“Just Going through the Motions….”: A Qualitative Exploration of Athlete Perceptions of Social Loafing in Training and Competition Contexts — Implica…
2014
Semi-structured interviews were conducted with twenty team sport athletes representing a range of different sports with the aim of investigating their views relating to social loafing in training and competition. General themes investigated and subsequent content analysis highlighted factors that promote or reduce the extent of social loafing. Determinants of self-loafing were grouped according to three distinct categories: Group processes; Task characteristics and Individual perceptions. Social loafing among others was perceived to be prevalent in both the training and competition scenarios with more examples of social loafing provided in the training situation. The signs of social loafin…
Música despersonalizada y música participativa : una propuesta terminológica desde la sociomusicología
2017
espanolLa musica, a pesar del ingente trabajo realizado desde la Filosofia, la Sociologia y la Musicologia, sigue utilizando cotidianamente un aparato conceptual poco riguroso. Todavia hoy se utilizan terminos que proceden del ambito linguistico coloquial, con una carga ideologica notable y basados en una vision de la realidad social sesgada de forma etnocentrica y elitista. Otro elemento que se suma a esta remora cientifica es el pecado original que supone la division entre Musicologia –centrada en la historia y ciencias de la musica que se producia en las academias occidentales– y la Etnomusicologia –ocupada en las manifestaciones del resto de las otras sociedades y de los otros grupos so…
Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.
2003
A series of 2,3-disubstituted indenes, which are analogues of the widely used histamine H(1) receptor antagonist dimethindene, have been synthesized and studied as muscarinic and histamine receptor antagonists. The affinities of these compounds for the five human muscarinic receptor subtypes (M(1)-M(5)) and for human histamine H(1) receptors were determined in radioligand binding studies using membranes from transfected Chinese hamster ovary (CHO) cells and [(3)H]N-methylscopolamine ([(3)H]NMS). The results demonstrate that the diisopropyl analogue 19 has a similar high affinity as (S)-dimethindene at M(2) receptors ((S)-dimethindene: pK(i) = 7.52; (-)-19: pK(i) = 7.37) with an improved sel…
A mid-term estimate of 2018/2019 vaccine effectiveness to prevent laboratory confirmed A(H1N1)pdm09 and A(H3N2) influenza cases in Sicily (Italy)
2019
Abstract Influenza season started in Italy during the month of October 2018, approaching the epidemic peak in January 2019. This report aim to explore the mid-term virologic surveillance data of the 2018–2019 influenza season in Sicily and to estimate the effectiveness of seasonal influenza vaccine (VE) against A(H1N1)pdm09 and A(H3N2) influenza viruses. A test-negative design was used to evaluate influenza VE. In Sicily, almost all influenza infections were sustained by influenza type A viruses, of which 62.3% were A(H3N2) and 36.3% A(H1N1)pdm09. A reduction of laboratory confirmed influenza cases in Sicilian population immunized against influenza were observed. In particular, an overall s…
A Th1 but not a Th17 response is present in the gastrointestinal involvement of Behçet's disease
2010
OBJECTIVES: Behçet's disease has been historically classified as a Th1 disease. The recently described IL-17/IL-23 pathway seems to play an important role in many inflammatory diseases and in the intestinal abnormalities of AS and CD. The aim of the present study was to evaluate the IL-17/IL-23 axis in parallel with Th1 and IL-27 response in the intestine of patients with BD and gastrointestinal abnormalities. METHODS: Quantitative TaqMan reverse transcriptase-polymerase chain reaction (RT-PCR) was utilised for all determinations on ileal biopsy specimens obtained from BD, AS and CD patients. The serum levels of Th1 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay. RES…
Sähköä ja alkemiaa: Tekoälydiskurssit Yleisradion verkkoartikkeleissa
2021
Tässä artikkelissa tarkastelemme sitä, millaisena ja miten tekoäly esitetään suomalaisessa julkisessa keskustelussa, ja ketkä tekoälystä suurelle yleisölle kertovat. Aineistona olemme käyttäneet Yleisradion verkkosivujen tekoälyä käsitteleviä artikkeleja. Tulosten perusteella tekoälystä pääsevät kertomaan useimmin talouden ja teollisuuden aloilla työskentelevät miehet. Aineistossa esiintyneet tekoälytulevaisuuskuvaukset pitäytyvät pitkälti nykyisen länsikeskeisen kapitalistisen maailmankuvan sisällä. Toisin sanoen, ne eivät haastaneet tai ylittäneet vallitsevaa status quoa, vaan näkivät tulevaisuuden pikemminkin lineaarisena kehityksenä nykytilasta. Aiemman tutkimuksen perusteella yleinen k…
Equivalent Non-Linearization of Hysteretic Systems by Means of RPS
2018
BackgroundThe analysis of elastoplastic systems with hardening (Bouc-Wen systems) under stochastic (seismic) loads needs the evaluation of higher order statistics even in the simplest case of normal distributed input. ObjectiveIn this paper, a non-linearization technique is proposed in order to evaluate the moments of any order of the response. MethodThis technique is developed by means of a nonlinear class of systems whose statistics are a priori known. The parameters of such systems can be chosen in such a way that the two systems are equivalent in a wide sense. Result & ConclusionIn the paper, the strategy to obtain the equivalence and the reliability of the results are discussed.
LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming.
2010
AbstractA key event in the successful induction of adaptive immune responses is the antigen-specific activation of T cells by dendritic cells (DCs). Although LFA-1 (lymphocyte function–associated antigen 1) on T cells is considered to be important for antigen-specific T-cell activation, the role for LFA-1 on DCs remains elusive. Using 2 different approaches to activate LFA-1 on DCs, either by deletion of the αL-integrin cytoplasmic GFFKR sequence or by silencing cytohesin-1–interacting protein, we now provide evidence that DCs are able to make use of active LFA-1 and can thereby control the contact duration with naive T cells. Enhanced duration of DC/T-cell interaction correlates inversely …
Nucleosome-specific, Time-dependent Changes in Histone Modifications during Activation of the Early Growth Response 1 (Egr1) Gene
2014
Histone post-translational modifications and nucleosome remodeling are coordinate events involved in eukaryotic transcriptional regulation. There are relatively few data on the time course with which these events occur in individual nucleosomes. As a contribution to fill this gap, we first describe the nature and time course of structural changes in the nucleosomes -2, -1, and +1 of the murine Egr1 gene upon induction. To initiate the transient activation of the gene, we used the stimulation of MLP29 cells with phorbol esters and the in vivo activation after partial hepatectomy. In both models, nucleosomes -1 and +1 are partially evicted, whereas nucleosomes +1 and -2 slide downstream durin…
Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects.
1997
Abstract The current study was carried out to elucidate the immunoregulatory changes induced by venom immunotherapy (VIT) in bee or wasp allergic subjects. All subjects included in this study had a history of severe systemic allergic reactions to stings of the respective insect as well as positive skin tests with the respective venom or venom-specific IgE in the sera. Parameters assessed in peripheral blood mononuclear cells (PBMC) before and after initiation of VIT (rush therapy reaching a maintenance dose of 100 micrograms venom injected subcutaneously within 1 week) were expression of CD3, CD4, CD8, CD45RA, CD45RO, interleukin (IL)-2 receptor (R) alpha, IL-4R, IL-12R, Fc epsilon RII, CD4…