Search results for "H1N1 subtype"

showing 10 items of 42 documents

Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin …

2010

Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating in Italy were examined, focusing on amino acid changes at position 222 because of its suggested pathogenic relevance. Among 169 patients, the D222G substitution was detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mild cases, whereas the D222E mutation was more frequent and evenly distributed in mild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among school children confirms reported human-to-human transmission of viruses mutated at amino acid position 222.

MaleMolecular surveillance; Pandemic influenza A(H1N1); Haemagglutinin mutations; Italy from May 2009 to February 2010pandemic influenzasurveillance of pandemic influenza A(H1N1); Molecular surveillance; pandemic influenzaEpidemiologyvirusesHaemagglutinin mutationssurveillance of pandemic influenza A(H1N1)Settore MED/42 - Igiene Generale E Applicatamedicine.disease_causeSeverity of Illness IndexInfluenza A Virus H1N1 SubtypePandemic influenza A(H1N1)PandemicInfluenza A VirusA(H1N1)ChildMutationReverse Transcriptase Polymerase Chain ReactionTransmission (medicine)Adolescent; Adult; Age Distribution; Aged; Amino Acid Substitution; Child; Child Preschool; Female; Hemagglutinins; Humans; Infant; Influenza A Virus H1N1 Subtype; Influenza Human; Italy; Male; Middle Aged; Mutation; Population Surveillance; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Sex Distribution; Young Adult; PandemicsMiddle AgedItaly from May 2009 to February 2010Molecular surveillance; pandemic influenza; A(H1N1); Italy; haemagglutinin mutationsHemagglutininsMolecular surveillanceItalyChild PreschoolPopulation SurveillanceFemaleHumanAdultAdolescentBiologyDisease clusterDisease courseYoung AdultAge DistributionVirologyInfluenza HumanmedicineHumansH1N1 SubtypeSex DistributionPreschoolhaemagglutinin mutationsPandemicsAgedMolecular epidemiologyPublic Health Environmental and Occupational HealthPandemic influenzaInfantVirologyInfluenzaMutational analysisAmino Acid SubstitutionMutationEurosurveillance
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Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19

2020

Abstract: BackgroundProgressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated morphologic and molecular changes in the peripheral lung of patients who die from Covid-19. MethodsWe examined 7 lungs obtained during autopsy from patients who died from Covid-19 and compared them with 7 lungs obtained during autopsy from patients who died from acute respiratory distress syndrome (ARDS) secondary to influenza A(H1N1) infection and 10 age-matched, uninfected control lungs. The lungs were studied with the use of seven-color immun…

MalePathologymedicine.medical_specialtyAngiogenesisPneumonia ViralAutopsy030204 cardiovascular system & hematologyNeovascularizationBetacoronavirus03 medical and health sciencesInfluenza A Virus H1N1 Subtype0302 clinical medicineInfluenza HumanmedicineHumans030212 general & internal medicineLungPandemicsAgedCause of deathAged 80 and overRespiratory Distress SyndromeNeovascularization PathologicSARS-CoV-2business.industryCOVID-19ThrombosisGeneral MedicineMiddle Agedmedicine.diseaseThrombosisPathophysiology3. Good healthPneumoniaFemaleAutopsyEndothelium VascularHuman medicinemedicine.symptomCoronavirus InfectionsRespiratory InsufficiencybusinessHuman PathologyThe New England journal of medicine
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Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year pro…

2018

Abstract Objective Cross-sectional studies show a lower health-related quality of life (HRQoL) in individuals with narcolepsy. We aimed to describe changes in HRQoL after two years of multidisciplinary follow-up in a cohort of mainly post-H1N1 vaccination narcolepsy type-1 (NT1) patients in Norway. Methods Prospective-cohort study. Narcolepsy diagnosis was based on the International Classification of Sleep Disorders (third edition). Psychiatric comorbidity was assessed using the Achenbach System of Empirically Based Assessment (ASEBA). HRQoL was evaluated with the Pediatric Quality of Life Inventory (PedsQL™ Generic Core Scales 4.0) at baseline and follow-up. Mean follow-up time was 20.7 (2…

MalePediatricsmedicine.medical_specialtyAdolescentComorbiditySeverity of Illness IndexYoung Adult03 medical and health sciencesInfluenza A Virus H1N1 Subtype0302 clinical medicineQuality of lifeInfluenza HumanmedicineHumansInternational Classification of Sleep DisordersProspective Studies030212 general & internal medicineChildProspective cohort studyNarcolepsyImmunization ProgramsNorwaybusiness.industryVaccinationGeneral Medicinemedicine.diseasehumanitiesPeer reviewVaccinationCross-Sectional StudiesTest scoreCohortQuality of LifeFemaleSodium Oxybatebusiness030217 neurology & neurosurgeryAdjuvants AnesthesiaNarcolepsySleep Medicine
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Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009–2010

2012

The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalizatio…

MaleViral DiseasesPediatricsNon-Clinical MedicinePulmonologyEpidemiology:Named Groups::Persons::Age Groups::Adult::Aged::Aged 80 and over [Medical Subject Headings]Grip A (H1N1):Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]DiseaseSocial and Behavioral Sciencesmedicine.disease_cause:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]Hospital patients:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Influenza A Virus H1N1 SubtypeGripe humanaSociologyRisk FactorsPandemicInfluenza A virusChildAged 80 and over:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]:Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Orthomyxoviridae::Influenzavirus A::Influenza A virus::Influenza A Virus H1N1 Subtype [Medical Subject Headings]COPDeducation.field_of_studyMultidisciplinary:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]QRMiddle AgedHospitalizationInfectious Diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings]Child Preschool:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]MedicineFemalePublic Health:Named Groups::Persons::Age Groups::Infant [Medical Subject Headings]Assistència hospitalàriaResearch ArticleAdultmedicine.medical_specialtyAdolescent:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]SciencePopulationHospitals -- Pacients:Check Tags::Male [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]InfluenzavirusVirusYoung AdultInfluenza HumanSubtipo H1N1 del Virus de la Influenza A:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineInfluenza virusesHumansEpidemiologia -- Investigació -- EspanyaEspanyaEpidemiologiaeducationPandemicsBiology:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]AgedHospital carePopulation Biologybusiness.industryPublic healthInfant NewbornCase-control studyInfant:Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings]medicine.disease:Check Tags::Female [Medical Subject Headings]SpainCase-Control StudiesH1N1 influenza:Diseases::Virus Diseases::RNA Virus Infections::Orthomyxoviridae Infections::Influenza Human [Medical Subject Headings]businessPLoS ONE
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Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

2012

The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis.A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used.The mean age was 38.5 years (SD 22.…

Malemedicine.disease_causeInfluenza A Virus H1N1 SubtypepreventionPregnancyInfluenza A virusPharmacology (medical)Young adultChildOriginal ResearchAged 80 and overNeuraminidase inhibitorbiologyMiddle AgedPrognosisHospitalizationInfectious DiseasesChild PreschoolFemaleMicrobiology (medical)Adultmedicine.medical_specialtyAdolescentCritical Caremedicine.drug_classNeuraminidaseadverse outcomesAntiviral AgentsYoung Adultlength of stayInternal medicineDiabetes mellitusIntensive careInfluenza HumanmedicineHumansSurvival analysisAgedPharmacologyPregnancyflubusiness.industrypandemicInfant NewbornInfantLength of Staymedicine.diseaseSurvival AnalysisSpainImmunologybiology.proteinbusinessNeuraminidase
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Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy

2019

Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually.Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza.Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) again…

Maletest-negative case-control study0301 basic medicinePrevalenceInfluenza vaccine effectiveness test-negative case-control study national influenza surveillance network ItalySettore MED/42 - Igiene Generale E ApplicataInfluenza A Virus H1N1 Subtype0302 clinical medicineDrug DiscoveryEpidemiology030212 general & internal medicineChildInfluenza vaccine effectivenessAged 80 and overnational influenza surveillance networkAge Factorsvirus diseasesMiddle Aged3. Good healthVaccinationTreatment OutcomeItalyInfluenza VaccinesChild PreschoolMolecular MedicineFemaleInfluenza vaccine effectiveness; Italy; national influenza surveillance network; test-negative case-control studyAdultmedicine.medical_specialtyAdolescentInfluenza vaccineImmunologyContext (language use)VirusYoung Adult03 medical and health sciencesInternal medicineInfluenza HumanmedicineAnimalsHumansAgedPharmacologybusiness.industryInfluenza A Virus H3N2 SubtypeCase-control studyInfant030104 developmental biologyImmunizationCase-Control StudiesbusinessExpert Review of Vaccines
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Detection of respiratory viral infections in neonates treated for suspicion of nosocomial bacterial sepsis: a feasibility study.

2013

There is a lack of knowledge concerning the frequency and significance of respiratory viral infections that occur in the neonatal intensive care unit. In the present study, all neonates with suspected nosocomial bacterial sepsis were screened for a panel of respiratory viruses. Respiratory viral infections were detected in 10% of these cases. This was comparable with the frequency of a blood-culture-proven sepsis.

Microbiology (medical)Malemedicine.medical_specialtyNeonatal intensive care unitRhinovirusvirusesMEDLINEBacteremiaPilot Projectsmedicine.disease_causeInfant Newborn DiseasesSepsisInfluenza A Virus H1N1 SubtypeIntensive Care Units NeonatalInfluenza A virusmedicineHumansLack of knowledgeProspective StudiesRespiratory systemIntensive care medicineProspective cohort studyRespiratory Tract InfectionsCross Infectionbusiness.industryInfant Newbornmedicine.diseaseAnti-Bacterial AgentsRespiratory Syncytial VirusesBacterial sepsisInfectious DiseasesPediatrics Perinatology and Child HealthFeasibility StudiesFemalebusinessThe Pediatric infectious disease journal
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Occurrence of a case of influenza A(H1N1)pdm09 and B co-infection during the epidemic season 2012–2013

2013

Abstract We report the detection of one case of co-infection with influenza A(H1N1)pdm09 and B, occurred during the 2012–2013 influenza season in Sicily. The dual infection was identified in a 18-year-old boy, who was not covered by specific vaccination and who had no other pre-existing risk factors. He presented classical symptoms of influenza-like illness developing no respiratory complications. A(H1N1)pdm09 viral concentration was initially about 10-fold higher than B virus, whereas its clearance was more rapidly achieved than in the case of B virus infection. Although influenza co-infection appears to be a rare event, a continued influenza surveillance activity is recommended, in order …

Microbiology (medical)Malemedicine.medical_specialtyRespiratory complicationsAdolescentMolecular Sequence DataBiologyInfluenza BSettore MED/42 - Igiene Generale E ApplicataMicrobiologyVirusInfluenza A Virus H1N1 SubtypeInfluenza HumanGeneticsmedicineInfluenza-like illnessHumansMolecular BiologySicilyEcology Evolution Behavior and SystematicsEpidemic seasonCoinfectionCo-infection Influenza; A(H1N1)pdm09; Influenza B; Influenza-like illnessPublic healthvirus diseasesInfluenza aVirologyVaccinationInfluenza B virusCo-infection InfluenzaInfectious DiseasesA(H1N1)pdm09ImmunologyEpidemiological MonitoringHuman mortality from H5N1Co infection
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Pandemic H1N1 influenza-associated myocarditis in a patient with Castleman's disease.

2013

We report on a patient with longstanding multicentric Castleman’s disease, hyaline-vascular type, who presented with nearly-fatal myocarditis associated with a 2009 pandemic H1N1 influenza virus infection. This is the first case of such an association described in the literature.

Myocarditisbusiness.industryvirusesCastleman DiseaseH1N1 influenzavirus diseasesGeneral MedicineDiseaseMiddle Agedmedicine.diseaseVirologyVirusMyocarditisInfluenza A Virus H1N1 SubtypeSpainPandemicInfluenza HumanMedicineHumansFemalebusinessPandemicsScottish medical journal
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Pandemic influenza A/H1N1 virus in a swine farm house in Sicily, Italy.

2012

This report describes a pandemic A/H1N1 (H1N1 pdm) virus outbreak occurred in December, 2009 in a swine farm used as research facility (Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione) for preclinical studies, located in Sicily, Italy. All the 13 pigs of the farm, showed cough, fever, inappetence and weakness. At the same time, an unvaccinated worker of the stabling showed influenza-like symptoms. RNAv extracted from two swabs collected from infected pigs resulted positive by Real Time RT-PCR for Influenza A virus. Furthermore, after growth on embryonated eggs, viral isolates were identified by Real Time RT-PCR specific for H1N1 pdm virus and characterized antigenically. …

Swine DiseasesReverse Transcriptase Polymerase Chain ReactionSwineA/H1N1 viruReal-Time Polymerase Chain ReactionDisease OutbreaksZoonosisInfluenza A Virus H1N1 SubtypeOrthomyxoviridae InfectionsInfluenza HumanAnimalsHumansSequencingFemalePandemicsSicilyPandemic influenza
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