Search results for "H2"

RNA-binding ability of PIPP in requires the entire protein

2003

Post-transcriptional fate of eukaryotic mRNAs depends on association with different classes of RNA-binding proteins (RBPs). Among these proteins, the cold-shock domain (CSD)-containing proteins, also called Y-box proteins, play a key role in controlling the recruitment of mRNA to the translational machinery, in response to environmental cues, both in development and in differentiated cells. We recently cloned a rat cDNA encoding a new CSD-protein that we called PIPPin. This protein also contains two putative double-stranded RNA-binding motifs (PIP(1) and PIP(2)) flanking the central CSD, and is able to bind mRNAs encoding H1 degrees and H3.3 histone variants. In order to clarify the role of…

Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.

2005

Although Th-2-mediated inflammation is a key therapeutic target in asthma, its relationship to altered structure and functions of the airways is largely unknown. In addition to inflammation, asthma is a disorder involving the airway epithelium that is more vulnerable to environmental injury and responds to this by impaired healing. This establishes a chronic wound scenario that is capable of sustaining chronic inflammation as well as remodeling. This response occurs as a consequence of activation of the epithelial-mesenchymal unit, involving reciprocal activities of growth factors belonging to the fibroblast growth factor, epidermal growth factor, and transforming growth factor-beta familie…

Divergent effects of biolistic gene transfer in a mouse model of allergic airway inflammation.

2007

Particle-mediated epidermal delivery (PMED) of allergen genes efficiently prevents systemic sensitization and suppresses specific immunoglobulin E synthesis. We investigated in a mouse model of allergic airway disease the effect of PMED on the elicitation of local inflammatory reactions in the lung. BALB/c mice were biolistically transfected with plasmids encoding beta-galactosidase (betaGal) as model allergen under control of the DC-targeting fascin promoter and the ubiquitously active cytomegalovirus promoter, respectively. Mice were challenged intranasally with betaGal-protein with or without intermediate sensitization with betaGal adsorbed to aluminiumhydroxide. Subsequently, local cyto…

Some coincidence and periodic points results in a metric space endowed with a graph and applications

2015

The purpose of this paper is to obtain some coincidence and periodic points results for generalized $F$-type contractions in a metric space endowed with a graph. Some examples are given to illustrate the new theory. Then, we apply our results to establishing the existence of solution for a certain type of nonlinear integral equation.

A criterion for homeomorphism between closed Haken manifolds

2003

In this paper we consider two connected closed Haken manifolds denoted by M^3 and N^3, with the same Gromov simplicial volume. We give a simple homological criterion to decide when a given map f: M^3-->N^3 between M^3 and N^3 can be changed by a homotopy to a homeomorphism. We then give a convenient process for constructing maps between M^3 and N^3 satisfying the homological hypothesis of the map f.

Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter

2008

Elevated intracellular cyclic AMP levels, which suppress the proliferation of naive T cells and type 1 T helper (Th1) cells are a property of T helper 2 (Th2) cells and regulatory T cells. While cyclic AMP signals interfere with the IL-2 promoter induction, they support the induction of Th2-type genes, in particular of il-5 gene. We show here that cyclic AMP signals support the generation of three inducible DNase I hypersensitive chromatin sites over the il-5 locus, including its promoter region. In addition, cyclic AMP signals enhance histone H3 acetylation at the IL-5 promoter and the concerted binding of GATA-3 and NFATc to the promoter. This is facilitated by direct protein-protein inte…

A quasiconformal composition problem for the Q-spaces

2017

Given a quasiconformal mapping $f:\mathbb R^n\to\mathbb R^n$ with $n\ge2$, we show that (un-)boundedness of the composition operator ${\bf C}_f$ on the spaces $Q_{\alpha}(\mathbb R^n)$ depends on the index $\alpha$ and the degeneracy set of the Jacobian $J_f$. We establish sharp results in terms of the index $\alpha$ and the local/global self-similar Minkowski dimension of the degeneracy set of $J_f$. This gives a solution to [Problem 8.4, 3] and also reveals a completely new phenomenon, which is totally different from the known results for Sobolev, BMO, Triebel-Lizorkin and Besov spaces. Consequently, Tukia-V\"ais\"al\"a's quasiconformal extension $f:\mathbb R^n\to\mathbb R^n$ of an arbitr…

Innovation in bacteriophage-based biocontrol of the plant pathogen ralstonia solanacearum through irrigation water

2017

Viability and Stimulation of Human Stem Cells from the Apical Papilla (hSCAPs) Induced by Silicate-Based Materials for Their Potential Use in Regener…

2020

Blood clot formation in the apical third of the root canal system has been shown to promote further root development and reinforcement of dentinal walls by the deposition of mineralized tissue, resulting in an advancement from traditional apexification procedures to a regenerative endodontic treatment (RET) for non-vital immature permanent teeth. Silicate-based hydraulic biomaterials, categorized as bioactive endodontic cements, emerged as bright candidates for their use in RET as coronal barriers, sealing the previously induced blood clot scaffold. Human stem cells from the apical papilla (hSCAPs) surviving the infection may induce or at least be partially responsible for the regeneration …

Measuring the Regional Incidence of Taxes and Public Expenditure: The Available Methodology and its Limitations

2014

This article reviews the basic methodology used to estimate the regional incidence of taxes and public expenditure, which we call the fiscal incidence approach, and compares it with the cash flow approach, which measures tax revenues and expenditures in terms of the associated monetary cash flows. In this context, it considers critically the particular version of the cash flow approach used in Spain. The article also looks at the different ways in which economists have tried to decompose fiscal balances into a structural or distributive component and a cyclical component, and critically reviews present practices.