Search results for "H2"
showing 10 items of 600 documents
Hedysarum coronarium-Based Green Composites Prepared by Compression Molding and Fused Deposition Modeling
2022
In this work, an innovative green composite was produced by adding Hedysarum coronarium (HC) flour to a starch-based biodegradable polymer (Mater-Bi®, MB). The flour was obtained by grinding together stems, leaves and flowers and subsequently sieving it, selecting a fraction from 75 μm to 300 μm. Four formulations have been produced by compression molding (CM) and fused deposition modeling (FDM) by adding 5%, 10%, 15% and 20% of HC to MB. The influence of filler content on the processability was tested, and rheological, morphological and mechanical properties of composites were also assessed. Through CM, it was possible to obtain easily homogeneous samples with all filler amounts.…
Creep Behavior of Poly(lactic acid) Based Biocomposites
2017
Polymer composites containing natural fibers are receiving growing attention as possible alternatives for composites containing synthetic fibers. The use of biodegradable matrices obtained from renewable sources in replacement for synthetic ones is also increasing. However, only limited information is available about the creep behavior of the obtained composites. In this work, the tensile creep behavior of PLA based composites, containing flax and jute twill weave woven fabrics, produced through compression molding, was investigated. Tensile creep tests were performed at different temperatures (i.e., 40 and 60 °C). The results showed that the creep behavior of the composites is strongly inf…
Involvement of EZH2-MYC loop and SALL4 in Epithelial-Mesenchymal Transition (EMT) and trastuzumab resistance process in HER2+ breast cancer
2021
Breast cancer (BC) is the most common type of cancer in females worldwide. It is also the second leading cause of death in women. BC is covered with heterogeneity properties, that leads to poor prognosis and therapeutic resistance. It has always been essential to unveil the different molecular mechanisms involved in BC cancer progression, finding a suitable treatment for the patients. This thesis focuses on unwrapping the various molecular mechanisms involved in HER2+ BC subtypes, as this denotes an aggressive phenotype among other subtypes of BC. Downregulation of miR-33b has been documented in many types of cancers and involves proliferation, migration, and epithelial-mesenchymal transiti…
Reinforcement Efficiency of Cellulose Microfibers for the Tensile Stiffness and Strength of Rigid Low-Density Polyurethane Foams
2020
Rigid low-density closed-cell polyurethane (PU) foams are widely used in both thermal insulation and structural applications. The sustainability of PU foam production can be increased by using bio-based components and fillers that ensure both enhanced mechanical properties and higher renewable material content. Such bio-based foams were produced using polyols derived from rapeseed oil and microcrystalline cellulose (MCC) fibers as filler. The effect of MCC fiber loading of up to 10 wt % on the morphology, tensile stiffness, and strength of foams has been evaluated. For estimation of the mechanical reinforcement efficiency of foams, a model allowing for the partial alignment of filler fibers…
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Data…
2021
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in penetrance determined by the type of pathogenic variant remain unknown. Objective. To determine cumulative incidences of cancer in carriers of truncating and missense or aberrant splicing pathogenic …
H2-Antihistaminika, 25. Mitt. Synthese und H2-antagonistische Wirkung monosubstituierter 1,2,4-Oxadiazol-3,5-diamine
1985
Es wurden die N3- bzw. N5-substituierten 1,2,4-Oxadiazol-3,5-diamine 4a-e und 5a-e dargestellt und auf Histamin-H2-antagonistische Aktivitat untersucht. H2-Antihistaminics, XXV: Synthesis and H2-Antagonistic Activity of Monosubstituted 1,2,4-Oxadiazole-3,5-diamines The N3-or N5-substituted 1,2,4-Oxadiazole-3,5-diamines 4a-e and 5a-e were prepared and tested for histamine H2-antagonistic activity.
Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 21. Mitt. Synthese und Wirkung Nα-substituierter Histamine
1980
Es wurden Nα-substituierte Histamine dargestellt und auf ihre agonistische Wirkung an Histamin H1- und H2-Rezeptoren untersucht. Structure-Activity Relationships of Histamine Analogues, XXI: Synthesis and Pharmacology of Nα-Substituted Histamines Nα-Substituted histamines were synthesized and investigated with regard to their agonistic activity at histamine H1 and H2 receptors.
Photochemistry of the H2O/CO System Revisited : The HXeOH···CO Complex in a Xenon Matrix
2017
We report on the complex of a noble-gas hydride HXeOH with carbon monoxide. This species is prepared via the annealing-induced H + Xe + OH···CO reaction in a xenon matrix, the OH···CO complexes being produced by VUV photolysis of the H2O···CO complexes. The H–Xe stretching mode of the HXeOH···CO complex absorbs at 1590.3 cm–1 and it is blue-shifted by 12.7 cm–1 from the H–Xe stretching band of HXeOH monomer. The observed blue shift indicates the stabilization of the H–Xe bond upon complexation, which is characteristic of complexes of noble-gas hydrides. The HXeOH···CO species is the first complex of a noble-gas hydride with carbon monoxide and the second observed complex of HXeOH. On the ba…
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
2020
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In the literature: April 2020
2020
Deficient DNA mismatch repair (dMMR) may be caused by germline or somatic mutations in mismatch repair genes ( MLH1 , MSH2 , MSH3 , MSH6 and PMS2 ) or through epigenetic silencing of MLH1 .1 dMMR induces a hypermutator phenotype, also known as microsatellite instability (MSI). Next-generation sequencing identifies MSI in 12 cancer types. The highest prevalence is seen in endometrial cancer (31.4%), followed by colorectal cancer (19.7%) and gastric cancer (GC, 19.1%). MSI was related to better prognosis for colorectal cancer and GC . Moreover, the dMMR/MSI hypermutator phenotype is thought to produce large numbers of immunogenic neoantigens that can be recognised by immune cells, leading to …