Search results for "H30"

Green Roofs as Effective Tools for Improving the Indoor Comfort Levels of Buildings—An Application to a Case Study in Sicily

2020

In the line of pursuing better energy efficiency in human activities that would result in a more sustainable utilization of resources, the building sector plays a relevant role, being responsible for almost 40% of both energy consumption and the release of pollutant substances in the atmosphere. For this purpose, techniques aimed at improving the energy performances of buildings&rsquo

Editorial: Physiology and Pathophysiology of Heat Shock Protein 60

2020

Methadone versus buprenorphine: data detected from Caltanissetta SER.T

2020

In last years, heroin-addicted have exponentially increased: this has made it necessary to identify a pharmacological strategy as effective as possible. With this purpose, a statistical investigation was conducted in a sample of individuals, aged between 18 and 50. They were diagnosed and subjected to different treatments at Ser.T of Caltanissetta (Sicily-Italy) during the period 2013-2017. The analyzed patients were treated with three different pharmacological therapy: methadone 0.1%, methadone 0.5%, buprenorphine and suboxone. We obtained percentages of responders, low responders and non-responders patients from data processing, based on used therapy. Considering pharmacological responses…

Research on macrolepidoptera species (Insecta: Lepidoptera) collected in Dumbrava Sibului Forest (Romania) in conditions of the year 2011 and their s…

2012

Macrolepidoptera fauna of Sibiu and its surroundings is studied for over 124 years by the naturalists Saxons. The collected material is preserved in the form of individual collections at the Natural History Museum in Sibiu. In addition to our material collected by us since 2001, data from these collections were a valuable documentary material for the present work. Our considerations on Macrolepidoptera flight periods are based on research conducted during the year 2011 from March to November in the protected area Dumbrava Sibiului. The natural conditions and the characteristics of the investigated area were revealed in several previous articles that could be found in the reference list. Thi…

Lepidoptera (Insecta: Lepidoptera) in the collection of Daniel Czekelius from Natural History Museum of Sibiu, collected from "Dumbrava Sibiului" for…

2011

Currently, fauna and ecological analysis of the landscape in which the reserves and Forest "Dumbrava Sibiu" shows a great scientific interest and practical for biological research in Sibiu. The results can contribute substantially to assessing the state of the world of insects and their evolution in the ecosystem studied, but also to establish their quantitative and qualitative changes over time. In the present work was studied the Lepidoptera collection of Transylvania Dr. Daniel Czekelius, and the paper presents a systematic list of species collected Macrolepidoptere since 1888-1929 in Forest "Dumbrava Sibiu".This paper can be considered a tribute and memory of Dr.Daniel Czekelius entomol…

Targeting Phosphatases and Kinases: How to Checkmate Cancer

2021

Metastatic disease represents the major cause of death in oncologic patients worldwide. Accumulating evidence have highlighted the relevance of a small population of cancer cells, named cancer stem cells (CSCs), in the resistance to therapies, as well as cancer recurrence and metastasis. Standard anti-cancer treatments are not always conclusively curative, posing an urgent need to discover new targets for an effective therapy. Kinases and phosphatases are implicated in many cellular processes, such as proliferation, differentiation and oncogenic transformation. These proteins are crucial regulators of intracellular signaling pathways mediating multiple cellular activities. Therefore, altera…

Meeting the Challenge of Targeting Cancer Stem Cells

2019

Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug resistance remains a critical hurdle. Indeed, the high mortality rate is associated with metastatic disease, which is mostly incurable due to the refractoriness of metastatic cells to current treatments. Increasing data demonstrate that tumors contain a small subpopulation of cancer stem cells (CSCs) able to establish primary tumor and metastasis. CSCs are endowed with multiple treatment resistance capabilities comprising a highly efficient DNA damage repair machinery, the activation of survival pathways, enhanced cellular plasticity, immune evasion and the adaptation to a hostile microenvironment. Due…

Ability of the ISAS3Fun Method to Detect Sperm Acrosome Integrity and Its Potential to Discriminate between High and Low Field Fertility Bulls

2021

The objective of the present study was to investigate whether fertility differences in bulls are reflected in variations of sperm quality when analysing only one ejaculate per male. Two experiments were performed. In the first experiment, frozen semen samples from 20 adult bulls were tested

Effects of n-3 Polyunsaturated Fatty Acids (ω-3) Supplementation on Some Cardiovascular Risk Factors with a Ketogenic Mediterranean Diet

2015

Background: the ketogenic diet (KD) has become a widely used nutritional approach for weight loss. Some of the KD’s positive effects on metabolism and cardiovascular risk factors are similar to those seen after n-3 polyunsaturated fatty acids (ω-3) supplementation. We hypothesized that a ketogenic Mediterranean diet with phytoextracts combined with ω-3 supplementation may have increased positive effects on cardiovascular risk factors and inflammation. Methods: We analyzed 34 male overweight subjects

Lipoproteins and Cardiovascular Disease: An Update on the Clinical Significance of Atherogenic Small, Dense LDL and New Therapeutical Options

2021

Dyslipidemia is a potent risk factor for the genesis and progression of cardiovascular disease (CVD), and both the concentration and type of low-density lipoproteins (LDL) augment this association. The small, dense LDL (sdLDL) subfraction is the subtype which is most strongly predictive of atherosclerosis and cardiovascular events. In addition to the traditionally available lipid-lowering treatment options, certain novel therapies have been shown to favorably impact sdLDL, among them the antidiabetic class of agents known as glucagon-like peptide 1 receptor agonists (GLP1-RAs). These drugs seem to alter the pathophysiologic mechanisms responsible for the formation and accumulation of athero…