Search results for "HAP"
showing 10 items of 2767 documents
Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein
2004
This article is available from: http://www.biomedcentral.com/1472-6807/4/7
Assessing autophagy in archived tissue or how to capture autophagic flux from a tissue snapshot
2020
This article belongs to the Special Issue Autophagy in Cancer.
Black hole lightning due to particle acceleration at subhorizon scales
2015
Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry, but still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here, we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC telescopes revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20\% of the gravitational radius of its central black hole. We suggest that the emission is associated …
Further studies on associations between leprosy and genetic markers in human serum.
1973
Seven serum proteins were typed on a sample of 910 individuals from Angola, Africa. The sample consisted of both leprosy patients and healthy controls from the same geographical area. Significant associations with leprosy were found for the Hp and Pi systems. The results are discussed.
Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages rela…
2010
Recently it has been reported that low serum IL-10 levels are associated with an increased susceptibility for metabolic syndrome and type 2 diabetes mellitus (T2DM). We investigated whether the -1087G/A (rs1800896), -824C/T (rs1800871), -597C/A (rs1800872) IL-10 polymorphisms were associated with type 2 diabetes in a study on a cohort of Italian Caucasians comprising 490 type 2 diabetic and 349 control subjects. Stratifying the data according to IL-10 genotypes, trends for the progressive increase of glucose and neutrophil levels were observed in -1087GG vs. -1087GA vs. -1087AA positive diabetic patients (-1087GG < -1087GA < -1087AA). In addition, evaluating the laboratory parameters accord…
Associations of resting and peak fat oxidation with sex hormone profile and blood glucose control in middle-aged women.
2022
Background and Aims Menopause may reduce fat oxidation. We investigated whether sex hormone profile explains resting fat oxidation (RFO) or peak fat oxidation (PFO) during incremental cycling in middle-aged women. Secondarily, we studied associations of RFO and PFO with glucose regulation. Method and Results We measured RFO and PFO of 42 women (age 52–58 years) with indirect calorimetry. Seven participants were pre- or perimenopausal, 26 were postmenopausal, and nine were postmenopausal hormone therapy users. Serum estradiol (E2), follicle-stimulating hormone, progesterone, and testosterone levels were quantified with immunoassays. Insulin sensitivity (Matsuda index) and glucose tolerance (…
Platelet, Not Endothelial, P-Selectin Expression Contributes to Generation of Immunity in Cutaneous Contact Hypersensitivity
2010
Leukocyte extravasation is a prerequisite for host defense and autoimmunity alike. Detailed understanding of the tightly controlled and overlapping sequences of leukocyte extravasation might aid development of novel therapeutic strategies. Leukocyte extravasation is initiated by interaction of selectins with appropriate carbohydrate ligands. Lack of P-selectin expression leads to decreased contact hypersensitivity responses. Yet, it remains unclear if this is due to inhibition of leukocyte extravasation to the skin or due to interference with initial immune activation in lymph nodes. In line with previous data, we here report a decreased contact hypersensitivity response, induced by 2,4,-di…
Registration-based Construction of a Whole-body Human Phantom Library for Anthropometric Modeling.
2020
Various computational human phantoms have been proposed in the past decades, but few of them include delicate anthropometric variations. In this study, we build a whole-body phantom library including 145 anthropometric parameters. This library is constructed by registration-based pipeline, which transfers a standard whole-body anatomy template to an anthropometry-adjustable body shape library (MakeHuman™). Therefore, internal anatomical structures are created for body shapes of different anthropometric parameters. Based on the constructed library, we can generate individualized whole-body phantoms according to given arbitrary anthropometric parameters. Moreover, the proposed phantom library…
ANÁLISIS SOBRE LAS FORMAS CORPORALES Y LOS PATRONES DE ACTIVIDAD FÍSICA DOMINANTES EN UNA COLECCIÓN DE LIBROS PARA COLOREAR
2014
Los materiales curriculares juegan un papel importante en la construcción del concepto del cuerpo debido a que son transmisores de conocimientos, ideas y valores. El objetivo del estudio consiste en analizar si las imágenes de una colección de libros para colorear y dibujar titulada Doodles para niños y Doodles para niñas señalan estereotipos sexistas sobre los modelos corporales y patrones de actividad física dominantes. Un grupo observacional independiente estudió las imágenes del cuerpo en los dos libros a través de un análisis de contenido con un sistema de categorías (género, edad, somatotipo, espacio y tipo de actividad física) previamente validado por expertos. Por lo tanto, se encon…
Robust Allocation Rules in Dynamical Cooperative TU Games
2011
Robust dynamic coalitional TU games are repeated TU games where the values of the coalitions are unknown but bounded variables. We set up the game supposing that the Game Designer uses a vague measure of the extra reward that each coalition has received up to the current time to re-adjust the allocations among the players. As main result, we provide a constructive method for designing allocation rules that converge to the core of the average game. Both the set up and the solution approach also provide an insight on commonalities between coalitional games and stability theory.