Search results for "HARP"
showing 10 items of 114 documents
Negative regulators of integrin activity
2012
Integrins are heterodimeric transmembrane adhesion receptors composed of α- and β-subunits. They are ubiquitously expressed and have key roles in a number of important biological processes, such as development, maintenance of tissue homeostasis and immunological responses. The activity of integrins, which indicates their affinity towards their ligands, is tightly regulated such that signals inside the cell cruicially regulate the switching between active and inactive states. An impaired ability to activate integrins is associated with many human diseases, including bleeding disorders and immune deficiencies, whereas inappropriate integrin activation has been linked to inflammatory disorders…
Calibration and Validation of Thermal Infrared Remote Sensing Sensors and Land/Sea Surface Temperature algorithms over the Iberian Peninsula
2017
La Temperatura de la Superficie Terrestre (TST) y la Temperatura de la Superficie del Mar (TSM) son parámetros clave en los procesos físicos de intercambio de energía entre la superficie y la atmósfera. La TST/TSM están directamente relacionadas con el espectro Infrarrojo Térmico (TIR) que constituye la principal fuente de emisión de radiación de la superficie terrestre. El control de los datos térmicos se puede realizar con la Calibración Vicarea (VC) para, de esta forma, garantizar la calidad de los datos una vez el sensor a bordo de satélite está en órbita. Normalmente, la validación directa de los algoritmos de TST y la VC del espectro térmico se realiza con datos in-situ en tierra, mie…
Data from: Plant – herbivorous beetle networks: molecular characterization of trophic ecology within a threatened steppic environment
2015
DNA barcoding facilitates many evolutionary and ecological studies, including the examination of the dietary diversity of herbivores. In this study, we present a survey of ecological associations between herbivorous beetles and host plants from seriously threatened European steppic grasslands. We determined host plants for the majority (65%) of steppic leaf beetles (55 species) and weevils (59) known from central Europe using two barcodes (trnL and rbcL) and two sequencing strategies (Sanger for mono/oligophagous species and Illumina for polyphagous taxa). To better understand the ecological associations between steppic beetles and their host plants, we tested the hypothesis that leaf beetl…
Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of …
2016
During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory inputdriven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity-related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level. Therefore, we tested whether intact SWR events occurring during th…
Data from: Not only for egg yolk - functional and evolutionary insights from expression, selection and structural analyses of Formica ant vitellogeni…
2015
Vitellogenin, a storage protein, has been extensively studied for its egg-yolk precursor role, and it has been suggested to be fundamentally involved in caste differences in social insects. More than one vitellogenin copy has been reported in several oviparous species, including ants. However, the number and function of different vitellogenins, their phylogenetic relatedness and their role in reproductive queens and non-reproductive workers has been studied in few species only. We studied caste biased expression of vitellogenins in seven Formica ant species. Only one copy of conventional vitellogenin was identified in Formica species, and three vitellogenin homologues, derived from ancient …
The Pratz le Curtillet settlement
2016
Among the earliest habitats of the early Middle Ages studied in Franche-Comté, the Pratz le Curtillet a settlement sets itself apart by its location in the Jura highlands, renowned for its remoteness and inhospitable landscapes. On the Lizon plateau, the scope of the archaeological work explored on the 16 hectares and the quality of the remains still constitute an exceptional complex today. An imposing 16m by 13m stone building flanked by an annex forms the residential part of the estate, while sheltering fodder and livestock, while the second building houses a forge. Domestic and artisanal equipment provide ample documentation on the living conditions of this small community of high status…
Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative harm…
2017
Abstract Introduction A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. Methods Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility and validity of these reference labels is demonstrated in a simple …
The face of conflict: Significant sharp force trauma to the mid-facial skeleton in an individual of probable 16th–17th century date excavated from By…
2016
A variety of injuries have always been associated with violence, consequences of which people had to deal with. In this paper we present a complex of craniofacial and dental injuries resulted from sharp force trauma. The basis of our study was historical skeletal material excavated from archeological site in Byczyna (11th–17th century), Poland. An individual whose skeleton was exhumed from the grave No. 610 exhibited healed, oblique trauma of the left maxilla, damage to the crowns of right central and lateral incisors and concomitant luxation of the right maxillary central incisor. We describe the mechanism of this trauma and complications that resulted from damage to the masticatory appara…
Training labels for hippocampal segmentation based on the EADC-ADNI harmonized hippocampal protocol
2015
Abstract Background The European Alzheimer's Disease Consortium and Alzheimer's Disease Neuroimaging Initiative (ADNI) Harmonized Protocol (HarP) is a Delphi definition of manual hippocampal segmentation from magnetic resonance imaging (MRI) that can be used as the standard of truth to train new tracers, and to validate automated segmentation algorithms. Training requires large and representative data sets of segmented hippocampi. This work aims to produce a set of HarP labels for the proper training and certification of tracers and algorithms. Methods Sixty-eight 1.5 T and 67 3 T volumetric structural ADNI scans from different subjects, balanced by age, medial temporal atrophy, and scanner…
Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project
2015
Abstract Background A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 T and 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass cor…