Search results for "HAp"
showing 10 items of 2767 documents
Differing Daphnia magna assimilation efficiencies for terrestrial, bacterial, and algal carbon and fatty acids
2014
There is considerable interest in the pathways by which carbon and growthlimiting elemental and biochemical nutrients are supplied to upper trophic levels. Fatty acids and sterols are among the most important molecules transferred across the plant–animal interface of food webs. In lake ecosystems, in addition to phytoplankton, bacteria and terrestrial organic matter are potential trophic resources for zooplankton, especially in those receiving high terrestrial organic matter inputs. We therefore tested carbon, nitrogen, and fatty acid assimilation by the crustacean Daphnia magna when consuming these resources. We fed Daphnia with monospecific diets of high-quality (Cryptomonas marssonii) an…
Distinct bhaplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe
2015
Abstract: Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplo…
Design of Reliable and Efficient Banki-Type Turbines
2020
A new shape for the external surface of the Crossflow turbine blades is proposed, which allows for the preservation of hydraulic efficiency in spite of a significant maximum blade thickness providing mechanic robustness and reliability. The final shape of the blades is assessed using an iterative solution for two uncoupled models: a 2D computational fluid dynamic (CFD) and a structural 3D finite element method (FEM) analysis of a single blade. Application of the proposed methodology to the design of a power recovery system (PRS) turbine, a new backpressure Crossflow-type inline turbine for pressure regulation, and energy production in a real Sicilian site follows.
Microscopic calculation of the $\beta^-$ decays of $^{151}$Sm, $^{171}$Tm, and $^{210}$Pb with implications to detection of the cosmic neutrino backg…
2023
The electron spectral shapes corresponding to the low-$Q$ $\beta^-$-decay transitions $^{151}$Sm$(5/2^-_{\rm g.s.})\to\,^{151}\textrm{Eu}(5/2^+_{\rm g.s.})$, $^{151}$Sm$(5/2^-_{\rm g.s.})\to\,^{151}\textrm{Eu}(7/2^+_{1})$, $^{171}$Tm$(1/2^+_{\rm g.s.})\to\,^{171}\textrm{Yb}(1/2^-_{\rm g.s.})$, $^{171}$Tm$(1/2^+_{\rm g.s.})\to\,^{171}\textrm{Yb}(3/2^-_{1})$, $^{210}\textrm{Pb}(0^+_{\rm g.s.})\to\,^{210}\textrm{Bi}(1^-_{\rm g.s.})$, and $^{210}\textrm{Pb}(0^+_{\rm g.s.})\to\,^{210}\textrm{Bi}(0^-_{1})$ have been computed using beta-decay theory with several refinements for these first-forbidden nonunique (ff-nu) $\beta^-$ transitions. These ff-nu $\beta^-$ transitions have non-trivial electro…
Y hromosomas ģenētisko variāciju salīdzinājums baltu un austrumslāvu populācijās
2016
Maģistra darbs ir veltīts austrumslāvu populāciju Y hromosomas ģenētiskās struktūras īpatnību noteikšanai un iegūto rezultātu salīdzinājumam ar baltu un ziemeļaustrumu Eiropas populācijām. Pētījuma ietvaros tika noteikta Y hromosomas haplogrupu izplatība Kijevas un Novgorodas apgabala populācijās. Iegūtie rezultāti norāda, ka Kijevas apgabalā visizplatītākā haplogrupa ir R1a (39,71%), bet Novgorodas apgabalā – N1c (74,32%). Detalizējot rezultātus ar PCA un filoģenētisko Neighbour-Joining analīzi, tika noteikts, ka Novgorodas apgabala populācija ģenētiski atrodas vistuvāk somiem augstās N1c haplogrupas izplatības dēļ, savukārt, pēc R1a-M558 atzara izplatības pētītajā teritorijā, autore secin…
Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
2019
Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.
Promoter Activation in Dhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
2019
Abstract Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene‐sequence‐similarity‐based bioinformatics strategies, the actual access to these NPs for structure elucidation and bioactivity testing remains difficult. Deletion of the gene encoding the RNA chaperone, Hfq, results in strains losing the production of most NPs. By exchanging the native promoter of a desired BGC against an inducible promoter in Δhfq mutants, almost exclusive production of the corresponding NP from the targeted BGC in Photorhabdus, Xenorhabdus and Pseud…
Longitudinal trajectories of emotions among athletes in sports competitions: Does emotional intelligence matter?
2021
Abstract Objectives This research explored whether several subgroups of athletes representing distinct emotional trajectories could be shown to exist within the latent class growth analysis (LCGA) of pleasant and unpleasant sport emotions (anger, anxiety, dejection, excitement, happiness). A secondary aim was to explore whether athletes belonging to distinct emotional trajectories reported distinct scores of trait-emotional intelligence (EI) at time 1 (T1). Design A longitudinal three-wave measurement design (beginning, middle, and end of a competitive season) was used in the present study. Method A sample of 460 athletes completed the sport emotion questionnaire across three measurement ti…
Ploidy manipulation for genetic improvement in some Mediterranean fruit crops
2017
Plant breeding is focused on selection of new genotypes with improved traits. Conventional methods based on hybridization and those based on biotechnology (somatic hybridization, genetic transformation, ploidy manipulation, etc.) are used to create novel genetic variations. Biotechnology provides powerful tools for plant breeding, for instance, haploid technology allows achievement of homozygous lines from heterozygous parents in one step, which reduces significantly the time required by conventional methods. Concerning woody species, characterized by self-incompatibility, long juvenile period and high degree of heterozygosity, this technique is the only way to get homozygous lines. Haploid…
Transmission Electron Microscopy of GroEL, GroES, and the Symmetrical GroEL/ES Complex
1994
Two new 2-D crystal forms of the Escherichia coli chaperone GroEL (cpn60) 2 x 7-mer have been produced using the negative staining-carbon film (NS-CF) technique. These 2-D crystals, which contain the cylindrical GroEL in side-on and end-on orientations, both possess p21 symmetry, with two molecules in the respective unit cells. The crystallographically averaged images correlate well with those obtained by other authors from single particle analysis of GroEL and our own previous crystallographic analysis. 2-D crystallization of the smaller chaperone GroES (cpn10) 7-mer has also been achieved using the NS-CF technique. Crystallographically averaged images of GroES single particle images indic…