Search results for "HAp"
showing 10 items of 2767 documents
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
2006
Contains fulltext : 35205.pdf (Publisher’s version ) (Closed access) Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, nor…
Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.
2015
13 pages; International audience; We describe the first application of high-resolution 3D micro-computed tomography, together with 3D landmarks and geometric morphometrics, to map QTL responsible for variation in skull shape and size using a backcross between C57BL/6J and A/J inbred strains. Using 433 animals, 53 3D landmarks, and 882 SNPs from autosomes, we identified seven QTL responsible for the skull size (SCS.qtl) and 30 QTL responsible for the skull shape (SSH.qtl). Size, sex, and direction-of-cross were all significant factors and included in the analysis as covariates. All autosomes harbored at least one SSH.qtl, sometimes up to three. Effect sizes of SSH.qtl appeared to be small, r…
Dog sperm head morphometry: its diversity and evolution
2017
Dogs have been under strong artificial selection as a consequence of their relationship with man. Differences between breeds are evident that could be reflected in seminal characteristics. The present study was to evaluate differences in sperm head morphometry between seven well-defined breeds of dog: the British Bulldog, Chihuahua, German Shepherd, Labrador Retriever, Spanish Mastiff, Staffordshire Terrier, and Valencian Rat Hunting dog. Semen samples were obtained by masturbation and smears stained with Diff-Quik. Morphometric analysis (CASA-Morph) produced four size and four shape parameters. Length, Ellipticity, and Elongation showed higher differences between breeds. MANOVA revealed di…
The scattering and re-absorption of red and near-infrared chlorophyll fluorescence in the models Fluspect and SCOPE
2019
Scattering and re-absorption have been recognized as relevant aspects for the interpretation of solar induced chlorophyll fluorescence (SIF) in vegetation remote sensing. In an earlier study [Yang and Van der Tol, RSE 215, 97–108, 2018] we addressed the problem of scattering and re-absorption of near-infrared fluorescence in the vegetation canopy. In this study we analyse within-leaf re-absorption of both red and near-infrared fluorescence using the radiative transfer model Fluspect. The leaf scattering determines the ratio of backward to total leaf fluorescence emission Fb/(Fb + Ff). Fluspect reproduces this ratio with an RMSE of less than 0.1, and explains the observed dependence of the s…
Specialization and interaction strength in a tropical plant–frugivore network differ among forest strata
2011
The degree of interdependence and potential for shared coevolutionary history of frugivorous animals and fleshy-fruited plants are contentious topics. Recently, network analyses revealed that mutualistic relationships between fleshy-fruited plants and frugivores are mostly built upon generalized associations. However, little is known about the determinants of network structure, especially from tropical forests where plants' dependence on animal seed dispersal is particularly high. Here, we present an in-depth analysis of specialization and interaction strength in a plant-frugivore network from a Kenyan rain forest. We recorded fruit removal from 33 plant species in different forest strata (…
Cappelle di palazzo nella Sicilia del Trecento
2018
Nei palazzi e nei castelli dell’aristocrazia siciliana, realizzati ex-novo o rinnovati nel corso del XIV secolo, la presenza di cappelle palatine appare una costante. Inserite tra gli ambienti della stessa residenza o costruite in volumi autonomi ma adiacenti alla prima, esse contribuiscono a definirne il rango, in un ambiguo equilibrio tra sfera pubblica e privata. Infatti, sebbene destinate essenzialmente a una fruizione privata - della quale tuttavia non si conoscono con precisione modalità e frequenza - si tratta al contempo degli ambienti definiti con maggiore cura e con scelte formali che appaiono mirate a perseguire precise strategie di autorappresentazione, che oscillano tra modelli…
Relationship of a Body Shape Index and Body Roundness Index with carotid atherosclerosis in arterial hypertension.
2018
Background and aims: A Body Shape Index (ABSI) and Body Roundness Index (BRI) are two new anthropometric adiposity indices that have shown to be associated better than BMI with adipose abdominal tissue, with the onset of diabetes and the risk of premature death. Little is known about the influence of ABSI and BRI on subclinical vascular damage. The study was aimed to assess the relationship between ABSI and BRI with carotid atherosclerosis damage in subjects with arterial hypertension. Methods and results: A total of 468 patients with arterial hypertension (30–80 years old) were enrolled; adiposity indices were calculated (BMI, WC, ABSI, BRI) and carotid ultrasonographic examination was per…
Improved model based on the Weibull distribution to describe the combined effect of pH and temperature on the heat resistance of Bacillus cereus in c…
2003
The effect of pH and temperature on the thermal inactivation of different strains of Bacillus cereus was modeled. Inactivation tests were carried out in carrot broth, following a full factorial design at four levels for temperature (from 90 to 105 degrees C, depending on the strain) and pH (6.2, 5.8, 5.2, and 4.7). Individual inactivation curves were analyzed by applying the Weibull model function (with percent discrepancy close to 20% for most cases), and the effects of pH and temperature on the scale parameter (designated D(beta)) and the shape parameter (beta) were also studied. Temperature and pH did not have a significant effect on the shape parameter (beta). The effect of temperature …
Antibody generation and immunoassay development in diverse formats for pyrimethanil specific and sensitive analysis
2012
Immunochemical techniques are complementary tools to modern analytical requirements. These methods rely on the production of immunoreagents with adequate binding properties. In the present study, a rationally designed and functionalized derivative of pyrimethanil-a modern anilinopyrimidine fungicide-was synthesized in order to generate for the first time high-affinity and selective antibodies to this xenobiotic. A single coupling procedure-based on hapten activation using N,N′-disuccinimidyl carbonate and purification of the active ester-was followed to prepare both immunizing and assay conjugates. Polyclonal antibodies were produced and characterized by enzyme-linked immunosorbent assay (E…
Gradientu pastiprināšanas algoritmu salīdzinājums un mainīgo būtiskuma analīze
2020
Šajā darbā tiek izpētīti un salīdzināti trīs no jaunākiem un plaši izmantotiem gradienta pastiprināšanas algoritmiem - XGBoost, LightGBM un CatBoost. Šie algoritmi tiek salīdzināti pēc to ātrdarbības, kā arī tendences uz pārpielāgošānos treniņa datiem. Tiek analizēta arī šo algoritmu spēja izmantot modelēšanā kategoriskus mainīgos. Papildus tiek izpētīti algoritmu hiperparametri un to ietekme uz algoritma pārpielāgošanos un modeļa precizitātes rādītājiem. Balstoties uz rezultātiem, tiek sniegti ieteikumi par hiperparametru skaņošanu. Otrajā eksperimenta daļā tiek izpētīta uz spēļu teorijas Šaplī vērtību balstītā metode mainīgo būtiskuma noteikšanai. Iegūtiem rādītājiem ar būtstrapa metodes …