Search results for "HAp"
showing 10 items of 2767 documents
El “giro morfológico”: la forma, condición del sentido
2006
This paper starts from the philosophical contradiction that we can call 'apory of logical fundament'. Logic appears, on the one side, as having the metaphysical pretensions of universality and wholeness and, on the other side, as having local efficiency in computers' concrete world. Several alternatives have tried to go over this apory, from alogical philosophies to logic amplifying attempts. René Thom's ontology changes the terms of the question and, instead of looking for the fundament in logic, he does so in topology. His slogan is: 'We have to found, not geometry in logic, but logic in geometry'. The fundamental ontological implication of this morphologic change is to find the sense con…
Music and Emotions in the Brain: Familiarity Matters
2011
The importance of music in our daily life has given rise to an increased number of studies addressing the brain regions involved in its appreciation. Some of these studies controlled only for the familiarity of the stimuli, while others relied on pleasantness ratings, and others still on musical preferences. With a listening test and a functional magnetic resonance imaging (fMRI) experiment, we wished to clarify the role of familiarity in the brain correlates of music appreciation by controlling, in the same study, for both familiarity and musical preferences. First, we conducted a listening test, in which participants rated the familiarity and liking of song excerpts from the pop/rock repe…
Understanding formability and geometrical accuracy of SPIF process used as reshaping approach
2021
Putting in place Circular Economy strategies is an urgent action to be undertaken. Manufacturing processes play a relevant role as efficient material reuse enabler. Scientists have to make an effort either to find new process or to rethink old process to reprocess End-of-life (EoL) components to recover both material and functions. In this paper, Single Point Incremental Forming (SPIF) process is used for reshaping sheet metal EoL components. Deep drawing process as well as uniaxial pre-straining (to imitate the End-of-Life component) followed by SPIF operations (to obtain the reshaped components) are set- up and implemented to form and reform aluminum sheet metal components. As the authors…
An energy efficiency analysis of single point incremental forming as an approach for sheet metal based component reuse
2020
Producing materials causes about 25% of all anthropogenic CO2 emissions. Metals play a significant role, steel and aluminum account for 24% and 3% of worldwide material related emissions respectively. Fostering resources efficiency strategies in the field of sheet components could lead to a significant environmental impact reduction. Reshaping could be one of the most efficient strategy to foster material reuse and lower the environmental impact due to material production. Specifically, for aluminum recycling, the overall energy efficiency of conventional route is very low and, more importantly, permanent material losses occur during re-melting because of oxidation. The present paper aims a…
Variation of haplotype distributions of two genomic regions of Citrus tristeza virus populations from eastern Spain.
2003
Genetic variation in natural populations of Citrus tristeza virus (CTV) was studied using haplotypes detected by single-strand conformation polymorphism (SSCP) analysis of two genomic regions (p20 gene and segment A, located in ORF1a). Analysis of 254 samples from 125 trees, collected at 12 different sites, yielded 8 different haplotypes for p20 and 5 for segment A. The most frequent haplotype of p20 was predominant at all sites, but several sites differed in the predominance of segment A haplotypes. At most sites, the homozygosity observed for the p20 gene tended to be higher than expected in a neutral evolution, whereas the opposite was true for segment A. Comparison of the populations at…
Hsp60 molecular anatomy and role in colorectal cancer diagnosis and treatment
2011
Quantitative changes in Hsp60 during the development of some tumors suggest that this chaperonin plays a role in carcinogenesis. A description of the specific role(s) of Hsp60 in tumor-cell growth and proliferation is still incomplete, but it is already evident that monitoring its levels and distribution in tissues and fluids has potential for diagnosis and staging, and for assessing prognosis and response to treatment. Although Hsp60 is considered an intramitochondrial protein, it has been demonstrated in the cytosol, cell membrane, vesicles, cell surface, extracellular space, and blood. The knowledge that Hsp60 occurs at all these locations opens new avenues for basic and applied research…
Mitochondrial compartment: a possible target of cadmium effects on breast epithelial cells.
2009
Cadmium–breast epithelial cell interactions were studied by analyzing some mitochondria-related aspects of stress response. We treated immortalized non-tumor breast cells with 5 or 50 μM CdCl2 for 24 or 96 h demonstrating that the exposure did not cause a significant mitochondrial proliferation, while it induced a significant increase in the respiratory activity and mitochondrial polarization. In addition, we found that hsp60 was up-regulated while hsp70 and COXII and COXIV were down-regulated. The mRNA for hsp70 remained constant and only the inducible form of the 70-kDa heat shock protein was over expressed. The mRNAs for COXII and COXIV remained constant after 24 h and increased after lo…
Rural settlement in the territorium of Ilici: the Roman farm of The Cabezo-Clot de Galvany (Elx, Alicante)
2015
Situado en el territorium de Ilici, en el paraje de El Clot de Galvany (Elx), junto a un humedal de tierras pobres, presentamos una granja romana (ss. I-III d.C.). Su posición periférica respecto al área centuriada ilicitana, los restos materiales aparecidos (molinos, ausencia de estructuras de transformación, aislamiento relativo) y la gran simplicidad estructural y funcional del conjunto remarcan el carácter autosuficiente de este núcleo. El área arqueológica tras la época romana queda deshabitada y sólo volvió a frecuentarse a partir del s. XVII, coincidiendo con el crecimiento demográfico de época moderna, como muestra la construcción de una ermita. Todo ello nos lleva a plantear cuesti…
Reorganization of Nuclear Domain 10 Induced by Papillomavirus Capsid Protein L2
2002
AbstractNuclear domains (ND) 10 are associated with proteins implicated in transcriptional regulation, growth suppression, and apoptosis. We now show that the minor capsid protein L2 of human papillomavirus (HPV) type 33 induces a reorganization of ND10-associated proteins. Whereas the promyelocytic leukemia protein, the major structural component of ND10, was unaffected by L2, Sp100 was released from ND10 upon L2 expression. The total cellular amount of Sp100, but not of Sp100 mRNA, decreased significantly, suggesting degradation of Sp100. Proteasome inhibitors induced the dispersal of Sp100 and inhibited the nuclear translocation of L2. In contrast to Sp100, Daxx was recruited to ND10 by …
Heat shock and Cd2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 an…
2003
Nuclear domains called ND10 or PML bodies might function as nuclear depots by recruiting or releasing certain proteins. Although recruitment of proteins through interferon-induced upregulation and SUMO-1 modification level of PML had been defined, it is not known whether release of proteins is regulated and has physiological consequences. Exposure to sublethal environmental stress revealed a sequential release of ND10-associated proteins. Upon heat shock Daxx and Sp100 were released but PML remained, whereas exposure to subtoxic concentrations of CdCl2 induced the release of ND10-associated proteins, including PML, with Sp100 remaining in a few sites. In both cases,recovery times were simil…