Search results for "HD"
showing 10 items of 4547 documents
A novel moniliformin derivative as pan-inhibitor of histone deacetylases triggering apoptosis of leukemia cells
2021
New and potent agents that evade multidrug resistance (MDR) and inhibit epigenetic modifications are of great interest in cancer drug development. Here, we describe that a moniliformin derivative (IUPAC name: 3-(naphthalen-2-ylsulfanyl)-4-{[(2Z)-1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene]methyl}cyclobut-3-ene-1,2-dione; code: MCC1381) bypasses P-gp-mediated MDR. Using transcriptomics, we identified a large number of genes significantly regulated in response to MCC1381, which affected the cell cycle and disturbed cellular death and survival. The potential targets of MCC1381 might be histone deacetylases (HDACs) as predicted by SwissTargetPrediction. In silico studies confirmed that MCC13…
Theoretical study on travelling web dynamics and instability under non-homogeneous tension
2013
Problems of dynamics and stability of a moving web, travelling between two rollers at a constant velocity, are studied using analytical approaches. Transverse vibrations of the web are described by a partial differential equation that includes the centrifugal force, in-plane tension, elastic reaction and nonstationary inertial terms. The model of a thin elastic plate subjected to bending and non-homogeneous tension is used to describe the bending moment and the distribution of membrane forces. The stability of the plate is investigated with the help of studies of small out-of-plane vibrations. The influence of linearly distributed in-plane tension on the characteristics of the web vibration…
Check in–check out intervention for supporting pupils’ behaviour: effectiveness and feasibility in Finnish schools
2018
Check In–Check Out (CICO) is a support programme for students with externalising problem behaviours. This study implemented in Finland is one of the first reports on the application of CICO in the European context. An experimental, multiple-baseline, single-case design is used to examine the effects of the CICO intervention on the problem behaviour and appropriate behaviour of three general education primary school pupils. The similarity of the observation data and the information provided in daily report card (DRC) are investigated to gauge the validity of the DRC assessments. The fidelity and social validity of the intervention are also analysed. CICO reduced problem behaviour in all pupi…
Real-time time-dependent density functional theory implementation of electronic circular dichroism applied to nanoscale metal–organic clusters
2020
| openaire: EC/H2020/838996/EU//RealNanoPlasmon Electronic circular dichroism (ECD) is a powerful spectroscopy method for investigating chiral properties at the molecular level. ECD calculations with the commonly used linear-response time-dependent density functional theory (LR-TDDFT) framework can be prohibitively costly for large systems. To alleviate this problem, we present here an ECD implementation within the projector augmented-wave method in a real-time-propagation TDDFT framework in the open-source GPAW code. Our implementation supports both local atomic basis sets and real-space finite-difference representations of wave functions. We benchmark our implementation against an existin…
Molecular biology, China and the West
2000
More than 15 years ago, in November 1985, I travelled to China for the first time. I joined a symposium on developmental biology in the Shanghai Institute of Cell Biology (CBI), organised by the Chinese Academy of Sciences and the Max‐Planck‐Gesellschaft in Germany. The symposium was meant to provide perspectives for the future of the Max Planck Guest Laboratory, just founded in the CBI. When I attended, I did not anticipate that my visit to Shanghai would initiate a long‐term commitment to China. I did not even expect to return to China in the near future. But early in 1987, my colleague Uli Schwarz from the Max Planck Institute of Developmental Biology in Tubingen, who was and still is in…
Study of the flying geese theory from a political point of view : a Japanese propaganda argument in the post world war II era
2009
The Flying Geese Theory (gankoo keitai hattenron 雁行形態発展論), dating from 1932, is one of the rare cases of a scientific theory that was used as a part of Japanese wartime propaganda, and which also survived and succeeded in the postwar era. It was used to legitimize the 'New Order in East Asia (TōA shinchitsujo 東亜新秩序) in 1938, and the new formulation of the 'Greater East Asia Co-Prosperity Sphere‘ (Dai TōA kyōeiken大東亜共栄圏) in 1940. Later in the 1980s the Flying Geese Theory/Pattern became the most successful candidate for explaining the expansion of ‗Asian economical miracles‘ in the postwar era. This study focuses on this famous piece of economical and political rhetoric. The intention is to …
Ytterbium-doped fibers for high-power fiber lasers
2021
Ytterbium (Yb) doped optical fibers are widely used in high-power applications and ultrafast lasing since they show adequate power-handling capability and provide desirable beam quality. Yb-doped fibers with large core area can support high power but often act as a multimode fiber and compromise the output beam quality. Hence, it is important to attain a proper balance between the power-handling capability and the beam quality. Yb-doped fibers as a gain medium in pulsed fiber laser systems are prone to nonlinear optical effects due to the presence of high peak power in the ultrashort pulses. Nonlinearity such as self phase modulation (SPM) affects the width and the shape of the pulse, both …
Impaired cellular cholesterol efflux by oxysterol-enriched high density lipoproteins.
1997
One of the proposed antiatherogenicity role of high-density lipoproteins (HDL) is believed to stimulate removal of cholesterol from the peripheral cells back to the liver for excretion. We have investigated the effects of oxidation-related modifications of HDL on their ability to stimulate cholesterol efflux from cultured cells. Human HDL (HDL3, 1.13 < d < 1.21 g/ml) have been modified either by malondialdehyde or by copper-mediated oxidation (Ox-HDL3). Compared with native HDL3, the modified HDL3 resulted in a significantly reduced efflux of labeled cholesterol from preloaded macrophages (P388D1 cell line). Analysis of lipid composition of Ox-HDL3 by gas chromatography revealed the presenc…
Transparency in two municipalities of great population of the Valencian Community: between mimetic isomorphism and the generation of legitimity
2020
Este trabajo de investigación tiene como objetivo fundamental la realización de un análisis sobre los elementos que han justificado la calidad de los procesos de asunción de la transparencia en los ayuntamientos de Alicante y València (2008-2017). En concreto, se partirá del neo-institucionalismo sociológico y de los índices de Transparencia Internacional para caracterizar esta herramienta de buen gobierno y la importancia relativa en ambos ayuntamientos. Entre algunos de los resultados preliminares que hemos obtenido, podemos destacar tanto el papel isomórfico de la legislación como la necesidad de mejorar la reputación de las instituciones estudiadas para implementar dichas políticas. The…
Thiourea Organocatalysts as Emerging Chiral Pollutants: En Route to Porphyrin-Based (Chir)Optical Sensing
2021
Environmental pollution with chiral organic compounds is an emerging problem requiring innovative sensing methods. Amino-functionalized thioureas, such as 2-(dimethylamino)cyclohexyl-(3,5-bis(trifluoromethyl)phenyl)thiourea (Takemoto’s catalyst), are widely used organocatalysts with virtually unknown environmental safety data. Ecotoxicity studies based on the Vibrio fischeri luminescence inhibition test reveal significant toxicity of Takemoto’s catalyst (EC50 = 7.9 mg/L) and its NH2-substituted analog (EC50 = 7.2–7.4 mg/L). The observed toxic effect was pronounced by the influence of the trifluoromethyl moiety. En route to the porphyrin-based chemosensing of Takemoto-type thioureas, their s…